RESUMO
This investigation examines the transport of metal- and pesticide-polluted dust emitted by one of the most relevant agricultural areas of Northwestern Mexico. In the contaminated area, an excessive water extraction of the aquifer and seawater intrusion caused the abandonment of fields, which are pollutant-loaded dust emitters. We used air mass forward trajectories (HYSPLIT) model to obtain particle trajectories in the wind and the use of banned pesticides as geochemical tracers for dust transported by wind. Fifty dust samples from 10 agriculture fields and 26 roof dust of a city close to the agricultural area were analyzed for their contents of zirconium, lead, arsenic, zinc, copper, iron, manganese, vanadium, and titanium, by portable X-ray fluorescence. Nine pesticides were analyzed in the roof dust and agricultural soil samples by gas chromatography. Results show that the distribution of metals was significantly different between active and abandoned fields. Arsenic-lead-copper was mainly concentrated in abandoned fields, while zinc-iron-manganese-titanium was dominant in active fields. Two potential sources of metal contamination were found by principal component analysis (PCA): (I) a mixture of traffic and agricultural sources and (II) a group related to agricultural activities. The occurrence of banned pesticides in dust deposited on roofs collected at nearby cities confirms the atmospheric transport from the agricultural area. The HYSPLIT results indicated that the dust emitted from agricultural fields can reach up to the neighboring states of Sonora, Mexico, and the USA. The impacts that these emissions can have on human health should be studied in future research.
Assuntos
Arsênio , Praguicidas , Humanos , Cobre , Manganês , Titânio , Arizona , Monitoramento Ambiental , Agricultura , Metais , Zinco , Ferro , PoeiraRESUMO
The presence of free-living amoebae of the genera Naegleria, Acanthamoeba and Balamuthia, which contain pathogenic species for humans and animals, has been demonstrated several times and in different natural aquatic environments in the northwest of Mexico. With the aim of continuing the addition of knowledge about immunology of pathogenic free-living amoebae, 118 sera from children and adolescents, living in three villages, were studied. Humoral IgG response against B. mandrillaris, N. fowleri and Acanthamoeba sp. genotype T4, was analyzed in duplicate to titers 1: 100 and 1: 500 by enzyme-linked immunosorbent assay (ELISA). Children and adolescents ages ranged between 5 and 16 years old, with a mean of 9 years old, 55% males. All tested sera were positive for the 1: 100 dilution, and in the results obtained with the 1: 500 dilution, 116 of 118 (98.3%) were seropositive for N. fowleri, 101 of 118 (85.6%) were seropositive for Acanthamoeba sp. genotype T4, and 43 of 118 (36.4%) were seropositive for B. mandrillaris. The statistical analysis showed different distributions among the three communities and for the three species of pathogenic free-living amoebae, including age. Lysed and complete cells used as Balamuthia antigens gave differences in seropositivity.
Assuntos
Acanthamoeba/imunologia , Anticorpos Antiprotozoários/sangue , Balamuthia mandrillaris/imunologia , Infecções Protozoárias do Sistema Nervoso Central/epidemiologia , Naegleria fowleri/imunologia , Adolescente , Amebíase/epidemiologia , Amebíase/imunologia , Infecções Protozoárias do Sistema Nervoso Central/imunologia , Infecções Protozoárias do Sistema Nervoso Central/parasitologia , Criança , Pré-Escolar , Ecossistema , Encefalite/epidemiologia , Encefalite/imunologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Imunoglobulina G/sangue , Masculino , México/epidemiologia , População RuralRESUMO
The available information concerning metal pollution in different dust sources and the health effects in children remains limited in Mexico. This study focuses on Hermosillo, which is an urbanized area located in the Sonoran Desert in which soil resuspension and dust emission processes are common. The metal content of arsenic (As), chromium (Cr), manganese (Mn), and lead (Pb) were determined in three dust sources (playgrounds, roofs, and roads), each representing different exposure media (EM) for these elements. The metal levels in dust were found in the order of Mn > Cr > Pb > As with the highest metal content found in road dust. Despite the similar average metal distributions, principal component analysis shows a clear separation of the three EM with playground dust related to Cr and Mn and road dust to As and Pb. However, the geoaccumulation index results indicate that dust samples are uncontaminated to moderately polluted, except for Pb in road dust, which is considerably high. In addition, the enrichment factor suggests an anthropogenic origin for all of the studied metals except for Mn. In this context, the hazard index (HI) for noncarcinogenic risk is >1 in this population and thus represents a potential health risk. The spatial distribution for each metal on EM and the HI related to the marginality index could represent a more accurate decision-making tool in risk assessment studies.
Assuntos
Poeira/análise , Exposição Ambiental/análise , Metais Pesados/análise , Poluentes do Solo/análise , Exposição Ambiental/estatística & dados numéricos , Humanos , Medição de Risco , UrbanizaçãoRESUMO
Cryptosporidium and Giardia are gastrointestinal disease-causing organisms transmitted by the fecal-oral route, zoonotic and prevalent in all socioeconomic segments with greater emphasis in rural communities. The goal of this study was to assess the risk of cryptosporidiosis and giardiasis of Potam dwellers consuming drinking water from communal well water. To achieve the goal, quantitative microbial risk assessment (QMRA) was carried out as follows: (a) identification of Cryptosporidium oocysts and Giardia cysts in well water samples by information collection rule method, (b) assessment of exposure to healthy Potam residents, (c) dose-response modelling, and (d) risk characterization using an exponential model. All well water samples tested were positive for Cryptosporidium and Giardia. The QMRA results indicate a mean of annual risks of 99:100 (0.99) for cryptosporidiosis and 1:1 (1.0) for giardiasis. The outcome of the present study may drive decision-makers to establish an educational and treatment program to reduce the incidence of parasite-borne intestinal infection in the Potam community, and to conduct risk analysis programs in other similar rural communities in Mexico.
Assuntos
Criptosporidiose/epidemiologia , Cryptosporidium/isolamento & purificação , Giardia/isolamento & purificação , Giardíase/epidemiologia , Água Subterrânea/microbiologia , Criptosporidiose/microbiologia , Giardíase/microbiologia , Humanos , Indígenas Norte-Americanos , México/epidemiologia , Medição de Risco , Poços de ÁguaRESUMO
Breast cancer incidence rates have declined among older but not younger women; the latter are more likely to be diagnosed with breast cancers carrying a poor prognosis. Epidemiological evidence supports an increase in breast cancer incidence following pregnancy with risk elevated as much as 10 years post-partum. We investigated the association between years since last full-term pregnancy at the time of diagnosis (≤10 or >10 years) and breast tumor subtype in a case series of premenopausal Hispanic women (n = 627). Participants were recruited in the United States, Mexico, and Spain. Cases with known estrogen receptor (ER), progesterone receptor (PR), and HER2 status, with one or more full-term pregnancies ≥1 year prior to diagnosis were eligible for this analysis. Cases were classified into three tumor subtypes according to hormone receptor (HR+ = ER+ and/or PR+; HR- = ER- and PR-) expression and HER2 status: HR+/HER2-, HER2+ (regardless of HR), and triple negative breast cancer. Case-only odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for HER2+ tumors in reference to HR+/HER2- tumors. Participants were pooled in a mixed-effects logistic regression model with years since pregnancy as a fixed effect and study site as a random effect. When compared to HR+/HER2- cases, women with HER2+ tumors were more likely be diagnosed in the post-partum period of ≤10 years (OR = 1.68; 95 % CI, 1.12-2.52). The effect was present across all source populations and independent of the HR status of the HER2+ tumor. Adjusting for age at diagnosis (≤45 or >45 years) did not materially alter our results (OR = 1.78; 95 % CI, 1.08-2.93). These findings support the novel hypothesis that factors associated with the post-partum breast, possibly hormonal, are involved in the development of HER2+ tumors.
Assuntos
Neoplasias da Mama/metabolismo , Receptor ErbB-2/metabolismo , Adulto , Neoplasias da Mama/epidemiologia , Feminino , Hormônios Esteroides Gonadais/fisiologia , Hispânico ou Latino , Humanos , Incidência , Modelos Logísticos , México/epidemiologia , Pessoa de Meia-Idade , Hormônios Placentários/fisiologia , Gravidez , Pré-Menopausa , Receptores de Estrogênio/metabolismo , Receptores de Progesterona/metabolismo , Espanha/epidemiologia , Estados Unidos/epidemiologia , Adulto JovemRESUMO
IMPORTANCE: The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual and community factors. OBJECTIVE: To estimate risk of H. pylori recurrence and assess factors associated with successful eradication 1 year after treatment. DESIGN, SETTING, AND PARTICIPANTS: Cohort analysis of 1463 randomized trial participants aged 21 to 65 years from 7 Latin American communities, who were treated for H. pylori and observed between September 2009 and July 2011. INTERVENTIONS: Randomization to 1 of 3 treatment groups: 14-day lansoprazole, amoxicillin, and clarithromycin (triple therapy); 5-day lansoprazole and amoxicillin followed by 5-day lansoprazole, clarithromycin, and metronidazole (sequential); or 5-day lansoprazole, amoxicillin, clarithromycin, and metronidazole (concomitant). Participants with a positive (13)C-urea breath test (UBT) 6 to 8 weeks posttreatment were offered voluntary re-treatment with 14-day bismuth-based quadruple therapy. MEASUREMENTS: Recurrent infection after a negative posttreatment UBT and factors associated with successful eradication at 1-year follow-up. RESULTS: Among participants with UBT-negative results who had a 1-year follow-up UBT (n=1091), 125 tested UBT positive, a recurrence risk of 11.5% (95% CI, 9.6%-13.5%). Recurrence was significantly associated with study site (P = .03), nonadherence to initial therapy (adjusted odds ratio [AOR], 2.94; 95% CI, 1.31-6.13; P = .01), and children in the household (AOR, 1.17; 95% CI, 1.01-1.35 per child; P = .03). Of the 281 with positive posttreatment UBT results, 138 completed re-treatment, of whom 93 tested UBT negative at 1 year. Among the 1340 who had a 1-year UBT, 80.4% (95% CI, 76.4%-83.9%), 79.8% (95% CI, 75.8%-83.5%), and 77.8% (95% CI, 73.6%-81.6%) had UBT-negative results in the triple, sequential, and concomitant groups, respectively (P = .61), with 79.3% overall effectiveness (95% CI, 77.1%-81.5%). In a single-treatment course analysis that ignored the effects of re-treatment, the percentage of UBT-negative results at 1 year was 72.4% (95% CI, 69.9%-74.8%) and was significantly associated with study site (P < .001), adherence to initial therapy (AOR, 0.26; 95% CI, 0.15-0.42; P < .001), male sex (AOR, 1.63; 95% CI, 1.25-2.13; P < .001), and age (AOR, 1.14; 95% CI, 1.02-1.27 per decade; P = .02). One-year effectiveness among all 1463 enrolled participants, considering all missing UBT results as positive, was 72.7% (95% CI, 70.3%-74.9%). CONCLUSIONS AND RELEVANCE: One year after treatment for H. pylori infection, recurrence occurred in 11.5% of participants who had negative posttreatment UBT results. Recurrence determinants (ie, nonadherence and demographics) may be as important as specific antibiotic regimen in determining the long-term success of H. pylori eradication interventions. Study findings are relevant to the feasibility of programs for the primary prevention of gastric cancer in high-incidence regions of Latin America. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01061437.
Assuntos
Anti-Infecciosos/uso terapêutico , Inibidores Enzimáticos/uso terapêutico , Infecções por Helicobacter/tratamento farmacológico , Neoplasias Gástricas/prevenção & controle , 2-Piridinilmetilsulfinilbenzimidazóis/uso terapêutico , Adulto , Amoxicilina/uso terapêutico , Bismuto/uso terapêutico , Testes Respiratórios , Claritromicina/uso terapêutico , Esquema de Medicação , Quimioterapia Combinada , Feminino , Seguimentos , Infecções por Helicobacter/epidemiologia , Infecções por Helicobacter/patologia , Humanos , Lansoprazol , América Latina/epidemiologia , Masculino , Adesão à Medicação , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Prevenção Primária , Recidiva , Risco , Neoplasias Gástricas/microbiologia , Adulto JovemRESUMO
BACKGROUND: Evidence from Europe, Asia, and North America suggests that standard three-drug regimens of a proton-pump inhibitor plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori infection than are 5-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens and thus could be suitable for eradication programmes in low-resource settings. Few studies in Latin America have been done, where the burden of H pylori-associated diseases is high. We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy. METHODS: Between September, 2009, and June, 2010, we did a randomised trial of empiric 14-day triple, 5-day concomitant, and 10-day sequential therapies for H pylori in seven Latin American sites: Chile, Colombia, Costa Rica, Honduras, Nicaragua, and Mexico (two sites). Participants aged 21-65 years who tested positive for H pylori by a urea breath test were randomly assigned by a central computer using a dynamic balancing procedure to: 14 days of lansoprazole, amoxicillin, and clarithromycin (standard therapy); 5 days of lansoprazole, amoxicillin, clarithromycin, and metronidazole (concomitant therapy); or 5 days of lansoprazole and amoxicillin followed by 5 days of lansoprazole, clarithromycin, and metronidazole (sequential therapy). Eradication was assessed by urea breath test 6-8 weeks after randomisation. The trial was not masked. Our primary outcome was probablity of H pylori eradication. Our analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, registration number NCT01061437. FINDINGS: 1463 participants aged 21-65 years were randomly allocated a treatment: 488 were treated with 14-day standard therapy, 489 with 5-day concomitant therapy, and 486 with 10-day sequential therapy. The probability of eradication with standard therapy was 82·2% (401 of 488), which was 8·6% higher (95% adjusted CI 2·6-14·5) than with concomitant therapy (73·6% [360 of 489]) and 5·6% higher (-0·04% to 11·6) than with sequential therapy (76·5% [372 of 486]). Neither four-drug regimen was significantly better than standard triple therapy in any of the seven sites. INTERPRETATION: Standard 14-day triple-drug therapy is preferable to 5-day concomitant or 10-day sequential four-drug regimens as empiric therapy for H pylori infection in diverse Latin American populations. FUNDING: Bill & Melinda Gates Foundation, US National Institutes of Health.
Assuntos
2-Piridinilmetilsulfinilbenzimidazóis/administração & dosagem , Amoxicilina/administração & dosagem , Antibacterianos/administração & dosagem , Claritromicina/administração & dosagem , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Metronidazol/administração & dosagem , Inibidores da Bomba de Prótons/administração & dosagem , Adulto , Idoso , Testes Respiratórios , Esquema de Medicação , Quimioterapia Combinada , Feminino , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/efeitos dos fármacos , Humanos , Lansoprazol , América Latina , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Resultado do Tratamento , Ureia/metabolismoRESUMO
Although, the Yaqui and Mayo valleys are the most important agricultural areas in Sonora, there is only limited data of the pesticides residue in soils in these valleys. This study measured the organochlorine pesticides (OCPs) in 234 soil samples (residential and agricultural) from 24 communities. The global results (mean, range) indicated that benzene hexachloride (19.2, ND-938.5 µg g(-1)), endrin (6.6, ND-377.3 µg g(-1)) and DDTs (36.45, ND-679.7 µg g(-1)) were the dominant contaminants. Soil is one of the most important routes of exposure to OCPs in the population of southern Sonora and this study can be used to establish background levels of OCPs.
Assuntos
Hidrocarbonetos Clorados/análise , Resíduos de Praguicidas/análise , Poluentes do Solo/análise , Monitoramento Ambiental , Poluição Ambiental/estatística & dados numéricos , MéxicoRESUMO
Arsenic presence in the water has become one of the most concerning environmental problems. Electrocoagulation is a technology that offers several advantages over conventional treatments such as chemical coagulation. In the present work, an electrocoagulation system was optimized for arsenic removal at initial concentrations of 100â µg/L using response surface methodology. The effects of studied parameters were determined by a 23 factorial design, whereas treatment time had a positive effect and current intensity had a negative effect on arsenic removal efficiency. With a p-value of 0.1629 and a confidence of level 99%, the type of electrode material did not have a significant effect on arsenic removal. Efficiency over 90% was reached at optimal operating conditions of 0.2â A of current intensity, and 7â min of treatment time using iron as the electrode material. However, the time necessary to accomplish with OMS arsenic guideline of 10â µg/L increased from 7 to 30â min when real arsenic-contaminated groundwater with an initial concentration of 80.2 ± 3.24â µg/L was used. The design of a pilot-scale electrocoagulation reactor was determined with the capacity to meet the water requirement of a 6417 population community in Sonora, Mexico. To provide the 1.0â L/s required, an electrocoagulation reactor with a working volume of 1.79â m3, a total electrode effective surface of 701â m2, operating at a current intensity of 180â A and an operating cost of 0.0208â US$/day was proposed. Based on these results, electrocoagulation can be considered an efficient technology to treat arsenic-contaminated water and meet the drinking water quality standards.
Assuntos
Arsênio , Água Subterrânea , Poluentes Químicos da Água , Purificação da Água , Eletrocoagulação , ÁguaRESUMO
The aim of this study was to evaluate the health risk of arsenic exposure by consumption of rice and its products marketed in northwestern Mexico. Sixty-six national and imported rice products were purchased in markets in northwestern Mexico, an endemic arsenic region. Total and inorganic arsenic in rice samples were analysed by inductively coupled plasma atomic emission spectroscopy and the risk assessment was evaluated according to the hazard quotient (HQ) and carcinogenic risk (CR). Total and inorganic arsenic in rice samples ranged from 0.06 to 0.29 mg/kg and from 0.03 to 0.13 mg/kg, respectively, and 40% of the analysed samples exceeded FAO/WHO arsenic recommended levels. The inorganic/total arsenic ratio ranged from 15% to 65%. The HQ and CR values for total and inorganic arsenic did not exceed safety levels. Therefore, rice supply in the northwestern of Mexico appears to be safe for human consumption.
Assuntos
Arsênio/análise , Arsenicais/análise , Carcinógenos/análise , Contaminação de Alimentos/análise , Oryza/química , Exposição Dietética , Humanos , México , Medição de Risco , Espectrofotometria AtômicaRESUMO
The aim of this study was to determine the distribution of cadmium (Cd) and lead (Pb) in muscle and liver tissue of Haemulopsis axillaris and Diapterus peruvianus from the Eastern Pacific in Mexico and to assess the health risk to consumers. Fish were collected as bycatch on the continental shelf between the coasts of Sinaloa and Guerrero (Eastern Pacific). Cd and Pb were quantified in muscle and liver tissue using graphite-furnace atomic absorption spectrophotometry (GF-AAS).Concentration of Cd was greater in muscle tissue than in liver tissue; with Pb, however, the opposite pattern was found. The highest concentration of Cd (0.177 µg g-1) was found in muscle tissue of H. axillaris from Sinaloa. For Pb, the highest level (0.692 µg g-1) was found in the liver tissue of H. axillaris also from Sinaloa. Levels of Cd and Pb in muscle tissue were both below Mexican Guidelines (0.5, 1.0 µg g-1 wet weight for Cd and Pb respectively) and International Guidelines. The hazard index (HI) for both metals in the edible portion of studied considering metal levels in the edible portion and the rate of fish consumption by the Mexican population (in adults and children) was less than 1 (HI < 1), values which do not represent a health risk to consumers.
Assuntos
Cádmio/análise , Peixes/metabolismo , Chumbo/análise , Músculos/metabolismo , Poluentes Químicos da Água/análise , Animais , Cádmio/química , Criança , Humanos , Chumbo/química , México , Medição de Risco , Espectrofotometria Atômica , Poluentes Químicos da Água/químicaRESUMO
Lacking in the literature are data addressing the extent to which changes in reproductive and lifestyle factors predispose women in developing nations to higher breast cancer rates, and the degree to which these are due to globalization influences. This article describes the development and psychometric assessment of an instrument intended to measure global, predominantly U.S., influences on breast cancer risk profile among women residing in Mexico. Using investigator consensus and a focus group methodology, the Measure of Globalization Influence on Health Risk (MGIHR) was developed and completed by 341 women. Psychometric analysis support the use of an 11-item Consumerism and Modernity scale and 7-item Reproductive Control and Gender Role scale. The MGIHR is a valid and reliable instrument for understanding changing lifestyle and reproductive factors for breast cancer risk and may provide a more complete understanding of breast cancer development and needed interventions.
Assuntos
Neoplasias da Mama/etiologia , Internacionalidade , Neoplasias da Mama/epidemiologia , Feminino , Grupos Focais , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Psicometria , Fatores de Risco , Inquéritos e QuestionáriosRESUMO
The risk of breast cancer transiently increases immediately following pregnancy; peaking between 3-7 years. The biology that underlies this risk window and the effect on the natural history of the disease is unknown. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to be dysregulated in breast cancer. We conducted miRNA profiling of 56 tumors from a case series of multiparous Hispanic women and assessed the pattern of expression by time since last full-term pregnancy. A data-driven splitting analysis on the pattern of 355 miRNAs separated the case series into two groups: a) an early group representing women diagnosed with breast cancer ≤ 5.2 years postpartum (n = 12), and b) a late group representing women diagnosed with breast cancer ≥ 5.3 years postpartum (n = 44). We identified 15 miRNAs with significant differential expression between the early and late postpartum groups; 60% of these miRNAs are encoded on the X chromosome. Ten miRNAs had a two-fold or higher difference in expression with miR-138, miR-660, miR-31, miR-135b, miR-17, miR-454, and miR-934 overexpressed in the early versus the late group; while miR-892a, miR-199a-5p, and miR-542-5p were underexpressed in the early versus the late postpartum group. The DNA methylation of three out of five tested miRNAs (miR-31, miR-135b, and miR-138) was lower in the early versus late postpartum group, and negatively correlated with miRNA expression. Here we show that miRNAs are differentially expressed and differentially methylated between tumors of the early versus late postpartum, suggesting that potential differences in epigenetic dysfunction may be operative in postpartum breast cancers.
Assuntos
Biomarcadores Tumorais/genética , Neoplasias da Mama/genética , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Hispânico ou Latino/genética , MicroRNAs/genética , Período Pós-Parto/genética , Adulto , Metilação de DNA , Feminino , Humanos , Pessoa de Meia-Idade , Análise de Sequência com Séries de Oligonucleotídeos , Gravidez , Adulto JovemRESUMO
BACKGROUND: Incidence rates for breast cancer are higher among Mexican-American (MA) women in the United States than women living in Mexico. Studies have shown higher prevalence of breast cancer risk factors in more acculturated than less acculturated Hispanic/Latinas in the United States. We compared the prevalence of behavioral risk factors and family history of breast cancer by level of acculturation and country of residence in women of Mexican descent. METHODS: Data were collected from 1,201 newly diagnosed breast cancer patients living in Mexico (n = 581) and MAs in the United States (n = 620). MA participants were categorized into three acculturation groups (Spanish dominant, bilingual, and English dominant); women living in Mexico were used as the referent group. The prevalence of behavioral risk factors and family history of breast cancer were assessed according to acculturation level, adjusting for age at diagnosis and education. RESULTS: In the adjusted models, bilingual and English-dominant MAs were significantly more likely to have a body mass index of 30 kg/m(2) or greater, consume more than one alcoholic beverage a week, and report having a family history of breast cancer than women living in Mexico. All three U.S. acculturation groups were significantly more likely to have lower total energy expenditure (≤533 kcal/d) than women in Mexico. English-dominant women were significantly less likely to ever smoke cigarettes than the Mexican group. CONCLUSIONS: Our findings add to the limited scientific literature on the relationships among acculturation, health behavior, and family history of breast cancer in Mexican and MA women.
Assuntos
Aculturação , Neoplasias da Mama/prevenção & controle , Comportamentos Relacionados com a Saúde/etnologia , Mamografia/estatística & dados numéricos , Programas de Rastreamento/estatística & dados numéricos , Adulto , Idoso , Neoplasias da Mama/etnologia , Neoplasias da Mama/psicologia , Família , Feminino , Predisposição Genética para Doença , Inquéritos Epidemiológicos , Humanos , Idioma , Estilo de Vida , Modelos Logísticos , Mamografia/psicologia , Programas de Rastreamento/psicologia , Americanos Mexicanos/psicologia , Americanos Mexicanos/estatística & dados numéricos , México/etnologia , Pessoa de Meia-Idade , Análise Multivariada , Prevalência , Fatores de Risco , Identificação Social , Estados Unidos/epidemiologiaRESUMO
BACKGROUND: Cryptosporidium oocysts and Giardia cysts can be transmitted by the fecal-oral route and may cause gastrointestinal parasitic zoonoses. These zoonoses are common in rural zones due to the parasites being harbored in fecally contaminated soil. This study assessed the risk of illness (giardiasis and cryptosporidiosis) from inhaling and/or ingesting soil and/or airborne dust in Potam, Mexico. METHODS: To assess the risk of infection, Quantitative Microbial Risk Assessment (QMRA) was employed, with the following steps: (1) hazard identification, (2) hazard exposure, (3) dose-response, and (4) risk characterization. RESULTS: Cryptosporidium oocysts and Giardia cysts were observed in 52% and 57%, respectively, of total soil samples (n=21), and in 60% and 80%, respectively, of air samples (n=12). The calculated annual risks were higher than 9.9 × 10(-1) for both parasites in both types of sample. CONCLUSIONS: Soil and air inhalation and/or ingestion are important vehicles for these parasites. To our knowledge, the results obtained in the present study represent the first QMRAs for cryptosporidiosis and giardiasis due to soil and air inhalation/ingestion in Mexico. In addition, this is the first evidence of the microbial air quality around these parasites in rural zones.
Assuntos
Ar/parasitologia , Criptosporidiose/epidemiologia , Cryptosporidium/isolamento & purificação , Exposição Ambiental , Giardia/isolamento & purificação , Giardíase/epidemiologia , Solo/parasitologia , Adulto , Animais , Criança , Pré-Escolar , Criptosporidiose/parasitologia , Cryptosporidium/crescimento & desenvolvimento , Giardia/crescimento & desenvolvimento , Giardíase/parasitologia , Humanos , Exposição por Inalação , México , Oocistos , Medição de RiscoRESUMO
BACKGROUND: We compared the distribution of breast cancer reproductive and hormonal risk factors by level of acculturation and country of residence in women of Mexican descent. METHODS: To compare the distribution of breast cancer reproductive and hormonal risk factors by level of acculturation and country of residence in women of Mexican descent, taking into account level of education, we analyzed data on 581 Mexican and 620 Mexican American (MA) women with a history of invasive breast cancer from the Ella Binational Breast Cancer Study. An eight-item language-based acculturation measure was used to classify MA women. Multivariate logistic regression was used to test associations between language acculturation, country of residence, and reproductive and hormonal risk factors. RESULTS: After adjustment for age and education, compared to women residing in Mexico, English-dominant MAs were significantly more likely to have an earlier age at menarche (<12 years; odds ratio [OR]=2.08; 95% confidence interval [CI], 1.30-3.34), less likely to have a late age at first birth (≥30 years; OR=0.49; 95% CI, 0.25-0.97), and less likely to ever breastfeed (OR=0.13; 95% CI, 0.08-0.21). CONCLUSIONS: Differences in reproductive and hormonal risk profile according to language acculturation and country of residence are evident; some of these were explained by education. Results support continued efforts to educate Mexican and MA women on screening and early detection of breast cancer along with promotion of modifiable factors, such as breastfeeding.
Assuntos
Aculturação , Neoplasias da Mama/prevenção & controle , Idioma , Americanos Mexicanos/psicologia , Adulto , Distribuição por Idade , Idoso , Arizona/epidemiologia , Neoplasias da Mama/etnologia , Neoplasias da Mama/psicologia , Feminino , Humanos , Entrevistas como Assunto , Modelos Logísticos , Americanos Mexicanos/estatística & dados numéricos , México/etnologia , Pessoa de Meia-Idade , Análise Multivariada , História Reprodutiva , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários , Texas/epidemiologiaRESUMO
Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26-3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26-2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.
RESUMO
The objective of this study was to evaluate the relationship between environmental arsenic exposure and serum matrix metalloproteinase (MMP)-9, a biomarker associated with cardiovascular disease and cancer. In a cross-sectional study of residents of Arizona, USA (n=215) and Sonora, Mexico (n=163), drinking water was assayed for total arsenic, and daily drinking water arsenic intake was estimated. Urine was speciated for arsenic, and concentrations were adjusted for specific gravity. Serum was analyzed for MMP-9 using ELISA. Mixed model linear regression was used to assess the relation among drinking water arsenic concentration, drinking water arsenic intake, urinary arsenic sum of species (the sum of arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid), and MMP-9, controlling for autocorrelation within households. Drinking water arsenic concentration and intake were positively associated with MMP-9, both in crude analysis and after adjustment for gender, country/ethnicity, age, body mass index, current smoking, and diabetes. Urinary arsenic sum of species was positively associated with MMP-9 in multivariable analysis only. Using Akaike's Information Criterion, arsenic concentration in drinking water provided a better fitting model of MMP-9 than either urinary arsenic or drinking water arsenic intake. In conclusion, arsenic exposure evaluated using all three exposure metrics was positively associated with MMP-9.
Assuntos
Arsênio/toxicidade , Água Potável/química , Exposição Ambiental , Metaloproteinase 9 da Matriz/sangue , Poluentes Químicos da Água/toxicidade , Adulto , Idoso , Arsênio/análise , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Poluentes Químicos da Água/análiseRESUMO
BACKGROUND: Published data support the presence of etiologic heterogeneity by breast tumor subtype, but few studies have assessed this in Hispanic populations. METHODS: We assessed tumor subtype prevalence and associations between reproductive factors and tumor subtypes in 1,041 women of Mexican descent enrolled in a case-only, binational breast cancer study. Multinomial logistic regression comparing HER2(+) tumors and triple-negative breast cancer (TNBC) to luminal A tumors was conducted. RESULTS: Compared with women with luminal A tumors, those with a later age at first pregnancy were less likely to have TNBC [OR, 0.61; 95% confidence interval (CI), 0.39-0.95], whereas those with three or more full-term pregnancies were more likely to have TNBC (OR, 1.68; 95% CI, 1.10-2.55). A lower odds of TNBC was shown for longer menstruation duration, whether before first pregnancy (OR, 0.78; 95% CI, 0.65-0.93 per 10 years) or menopause (OR, 0.79; 95% CI, 0.69-0.91 per 10 years). Patients who reported breastfeeding for more than 12 months were over twice as likely to have TNBC than luminal A tumors (OR, 2.14; 95% CI, 1.24-3.68). Associations comparing HER2(+) with luminal A tumors were weak or nonexistent except for the interval between last full-term pregnancy and breast cancer diagnosis. CONCLUSIONS: Findings show etiologic heterogeneity by tumor subtype in a population of Hispanic women with unique reproductive profiles. IMPACT: Identification of etiologically distinct breast tumor subtypes can further improve our understanding of the disease and help provide personalized prevention and treatment regimens.
Assuntos
Neoplasias da Mama/classificação , Neoplasias da Mama/etnologia , História Reprodutiva , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/patologia , Feminino , Humanos , Americanos Mexicanos , México/epidemiologia , Pessoa de Meia-Idade , Gravidez , Prevalência , Fatores de Risco , Estados Unidos/epidemiologiaRESUMO
Obesity at diagnosis of breast cancer is associated with higher all-cause mortality and treatment-associated toxicities. We evaluated the association between parity and obesity in the Ella study, a population of Mexican and Mexican-American breast cancer patients with high parity. Obesity outcomes included body mass index (BMI) ≥30 kg/m(2), waist circumference (WC) ≥35 in (88 cm), and waist-to-hip-ratio (WHR) ≥0.85. Prevalence of obesity ([BMI] ≥ 30 kg/m(2)) was 38.9 %. For WC, the multivariate odds ratio (OR) (95 % confidence interval [CI]) for having WC ≥ 35 inches in women with ≥4 pregnancies relative to those with 1-2 pregnancies was 1.59 (1.01-2.47). Higher parity (≥4 pregnancies) was non-significantly associated with high BMI (OR = 1.10; 95 % CI 0.73-1.67). No positive association was observed for WHR. Our results suggest WC is independently associated with high parity in Hispanic women and may be an optimal target for post-partum weight loss interventions.