Detalhe da pesquisa
1.
Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.
J Am Soc Nephrol
; 31(2): 350-364, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879336
2.
Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.
Arterioscler Thromb Vasc Biol
; 39(7): 1448-1457, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043077
3.
Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance.
Am J Physiol Endocrinol Metab
; 317(6): E1063-E1069, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31593502
4.
Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.
Br J Clin Pharmacol
; 85(4): 762-770, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30618054
5.
Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.
Eur Heart J
; 39(35): 3301-3310, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30219874
6.
Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.
Nanomedicine
; 13(8): 2565-2574, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28754465
7.
Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
Eur J Heart Fail
; 25(9): 1696-1707, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470101
8.
Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
JACC Heart Fail
; 11(7): 775-787, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37140510
9.
Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque.
Redox Biol
; 58: 102532, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375379
10.
A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation.
Front Pharmacol
; 13: 827686, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35548346
11.
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS-HFpEF study.
Eur J Heart Fail
; 24(12): 2251-2260, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36196462
12.
Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J Med Chem
; 65(17): 11485-11496, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005476
13.
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Cardiovasc Res
; 118(2): 517-530, 2022 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705529
14.
Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction.
Antioxidants (Basel)
; 12(1)2022 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36670895
15.
Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction.
Clin Transl Sci
; 14(3): 812-819, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32770730
16.
Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation.
Free Radic Biol Med
; 152: 91-99, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142878
17.
Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice.
Hepatol Commun
; 4(10): 1441-1458, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33024915
18.
Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients.
ESC Heart Fail
; 7(4): 1534-1546, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424988
19.
RNA sequencing data describing transcriptional changes in aorta of ApoE-/- mice after alpha 7 nicotinic acetylcholine receptor (α7nAChR) stimulation.
Data Brief
; 30: 105415, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258279
20.
Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling.
Sci Rep
; 9(1): 18765, 2019 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822739