Detalhe da pesquisa
1.
Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes.
Drug Metab Dispos
; 51(2): 174-182, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379710
2.
Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Pharmacogenet Genomics
; 32(8): 288-292, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997049
3.
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice.
Xenobiotica
; 51(7): 764-770, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34013847
4.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455676
5.
Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo.
Xenobiotica
; 49(11): 1303-1310, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30561249
6.
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Drug Metab Dispos
; 46(11): 1756-1766, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29777024
7.
Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics.
Pharmacol Res Perspect
; 12(3): e1197, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38644590
8.
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
Cell Metab
; 34(4): 564-580.e8, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385705