1.
Biosci Biotechnol Biochem
; 86(10): 1417-1422, 2022 Sep 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35973688
RESUMO
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial-mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases.