Detalhe da pesquisa
1.
Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases.
Chembiochem
; 24(14): e202300382, 2023 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37305956
2.
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Nature
; 519(7542): 247-50, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25533960
3.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
Bioorg Med Chem Lett
; 29(20): 126611, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31447084
4.
The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs.
Nucleic Acids Res
; 44(5): 2160-72, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26582911
5.
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
J Biol Chem
; 291(42): 21925-21944, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566546
6.
The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction.
Chem Sci
; 15(18): 6738-6751, 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38725499
7.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712280
8.
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.
J Biol Chem
; 291(49): 25763, 2016 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27913664
9.
Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques.
PLoS Comput Biol
; 7(10): e1002193, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22022248
10.
A Pathway Model to Understand the Evolution of Spike Protein Binding to ACE2 in SARS-CoV-2 Variants.
Biomolecules
; 12(11)2022 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36358957
11.
Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
Mol Cell Endocrinol
; 454: 39-49, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28572046
12.
Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.
Biochem Pharmacol
; 142: 96-110, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705698
13.
The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling.
Sci Signal
; 8(401): ra110, 2015 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26535008
14.
Modern homology modeling of G-protein coupled receptors: which structural template to use?
J Med Chem
; 52(16): 5207-16, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19627087
15.
Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.
Expert Opin Drug Discov
; 3(3): 343-355, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19672320
16.
Dopamine D2 receptors form higher order oligomers at physiological expression levels.
EMBO J
; 27(17): 2293-304, 2008 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18668123