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J Clin Gastroenterol ; 47(5): 437-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23426446

RESUMO

Probiotic strains of Lactobacillus are currently used in a variety of clinical practices with limited evidence to support their use. Lactobacillus species are a normal part of gastrointestinal flora, and bacteremia with probiotic strains of Lactobacillus is very uncommon. We describe a case of Lactobacillus bacteremia in a 17-year-old boy with ulcerative colitis managed with systemic corticosteroids and infliximab, who presented with fever to 102°F, flushing, and chills 1 week after starting Lactobacillus rhamnosus GG probiotics. Initial blood culture on day 2 of his fever was positive for Lactobacillus, however, subsequent blood cultures on day 3 and 5 were negative. He was treated empirically with antibiotics for 5 days and defervesced by day 8 of his illness. 16 S rRNA sequence analysis identified the organism from the patient's blood culture and probiotic capsule as L. rhamnosus with a 99.78% match for both the strains. This case report highlights the potential risk of Lactobacillus bacteremia in immunosuppressed patients with severe active ulcerative colitis.


Assuntos
Bacteriemia/microbiologia , Colite Ulcerativa/terapia , Lacticaseibacillus rhamnosus , Probióticos/efeitos adversos , Probióticos/uso terapêutico , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Infecções por Bactérias Gram-Positivas/microbiologia , Humanos , Hospedeiro Imunocomprometido , Lacticaseibacillus rhamnosus/classificação , Lacticaseibacillus rhamnosus/genética , Lacticaseibacillus rhamnosus/isolamento & purificação , Lacticaseibacillus rhamnosus/patogenicidade , Masculino , RNA Ribossômico 16S/genética , Fatores de Risco , Análise de Sequência de DNA
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