Optical-Radiation-Calorimeter Refinement by Virtual-Sensitivity Analysis.

Digital holographic interferometry (DHI) radiation dosimetry has been proposed as an experimental metrology technique for measuring absorbed radiation doses to water with high spatial resolution via noninvasive optical calorimetry. The process involves digitally recording consecutive interference patterns resulting from variations in the refractive index as a function of the radiation-absorbed dose. Experiments conducted on prototype optical systems revealed the approach to be feasible but strongly dependent on environmental-influence quantities and setup configuration. A virtual dosimeter reflecting the prototype was created in a commercial optical modelling package. A number of virtual phantoms were developed to characterize the performance of the dosimeter under ideal conditions and with simulated disruptions in environmental-influence quantities, such as atmospheric and temperature perturbations as well as mechanical vibrations. Investigations into the error response revealed that slow drifts in atmospheric parameters and heat expansion caused the measured dose to vary between measurements, while atmospheric fluctuations and vibration contributed to system noise, significantly lowering the spatial resolution of the detector system. The impact of these effects was found to be largely mitigated with equalisation of the dosimeter's reference and object path lengths, and by miniaturising the detector. Equalising path lengths resulted in a reduction of 97.5% and 96.9% in dosimetric error introduced by heat expansion and atmospheric drift, respectively, while miniaturisation of the dosimeter was found to reduce its sensitivity to vibrations and atmospheric turbulence by up to 41.7% and 54.5%, respectively. This work represents a novel approach to optical-detector refinement in which metrics from medical imaging were adapted into software and applied to a a virtual-detector system. This methodology was found to be well-suited for the optimization of a digital holographic interferometer.

Simulation-guided development of an optical calorimeter for high dose rate dosimetry.

Optical Calorimetry (OC) is based on interferometry and provides a direct measurement of spatially resolved absorbed dose to water by measuring refractive index changes induced by radiation. The purpose of this work was to optimize and characterize in software an OC system tailored for ultra-high dose rate applications and to build and test a prototype in a clinical environment. A radiation dosimeter using the principles of OC was designed in optical modelling software. Traditional image quality instruments, fencepost and contrast phantoms, were utilized both in software and experimentally in a lab environment to investigate noise reduction techniques and to test the spatial and dose resolution of the system. Absolute dose uncertainty was assessed by measurements in a clinical 6 MV Flattening Filter Free (FFF) photon beam with dose rates in the range 0.2-6 Gy/s achieved via changing the distance from the source. Design improvements included: equalizing the pathlengths of the interferometer, isolating the system from external vibrations and controlling the system's internal temperature as well as application of mathematical noise reduction techniques. Simulations showed that these improvements should increase the spatial resolution from 22 to 35 lp/mm and achieve a minimum detectable dose of 0.2 Gy, which was confirmed experimentally. In the FFF beam, the absolute dose uncertainty was dose rate dependent and decreased from 2.5 ± 0.8 to 2.5 ± 0.2 Gy for dose rates of 0.2 and 6 Gy/s, respectively. A radiation dosimeter utilizing the principles of OC was developed and constructed. Optical modelling software and image quality phantoms allowed for iterative testing and refinement. The refined OC system proved capable of measuring absorbed dose to water in a linac generated photon beam. Reduced uncertainty at higher dose rates indicates the potential for OC as a dosimetry system for high dose rate techniques such as microbeam and ultra-high dose-rate radiotherapy.

Accurate dosimetric measurement of large extended SSD fields for comparison to TPS models.

PURPOSE: There is little evidence in the literature which quantifies the accuracy of Treatment Planning Systems (TPSs) using large fields at extended SSD (eSSD). This paper introduces the approach taken at Christchurch Hospital, New Zealand to validate the use of the Monaco TPS for Total Body Irradiation (TBI) treatments. METHODS: A purpose-built device for allowing precise movements of block-like phantoms called a Phantom Mobility Device (PMD) was used for collecting measurements at eSSD. These measurements were used for determining the ability of the Monaco TPS (originally validated for SSDs between 80 and 110 cm) to accurately model dose distributions for TBI treatments at Christchurch Hospital on either treatment machine one (T1) or two (T2) with SSD values of 341 and 432.6 and clinically useful field sizes of 120 and 170 cm, respectively. RESULTS: We found that within the limits of measurement uncertainty the PMD contributed no determinable scatter to the measurements and proved a reliable approach for eSSD dose measurements. Additionally, by applying depth and off-axis distance constraints of use for TPS information it is possible to use the existing Monaco CCC model at eSSD for block phantom geometries. Dose Difference (DD) analysis showed a clinically acceptable agreement between the CCC model and measured data over a range of depths and off-axis distances. CONCLUSIONS: The PMD was determined to be a useful tool for accurate measurement of extended SSD treatment fields. Monaco TPS CCC model agreed well for block phantoms so future comparisons to anthropomorphic phantoms or patient data are feasible.

Optimising the use of EPIgray for 3DCRT breast treatments.

EPIgray is an in-vivo dosimetry system which uses electronic portal images to calculate dose delivered to a point of interest (POI) and the percentage dose difference (%DDiff) from expected dose. For 3D conformal radiotherapy (3DCRT) of breasts, a small shift between patient position on treatment compared to the planning CT is often clinically accepted. However due to the use of the planning CT in the EPIgray back-projection algorithm, acceptable shifts can have undue impact on EPIgray dose so it does not reflect true POI dose. At our centre ± 5.0% %DDiff tolerance is used for all treatment sites, however for breast treatments this effect causes false positive (FP) results, which may mean an actual treatment error is not detected. Patient position can be better represented within EPIgray using a contour correction (CC) method, increasing dose calculation accuracy. A custom breast-lung phantom was developed to validate use of CC, then EPIgray data of 30 breast patients were retrospectively analysed with CC. %DDiff before and after CC identified a FP rate. A process to determine optimal EPIgray tolerances for breast 3DCRT to reduce incidence of FP results is presented, based on analysis of factors influencing %DDiff and a receiver operator characteristic curve analysis of the retrospective study data. This process determined that a reduced tolerance of ± 3.5% would optimise utility of the EPIgray results, but this would require additional clinical resources to investigate the correspondingly increased rate of false negative results. Choice of tolerance requires consideration of workload and aims of the IVD program.

Total body irradiation in Australia and New Zealand: results of a practice survey.

Total body irradiation (TBI) is an important treatment modality for the preparation of patients for bone marrow transplants. It is technically challenging and the actual delivery may vary from clinic to clinic. Knowledge of the pattern of practice may be helpful for clinics to determine future practice. We carried out an email survey from April to September 2019 sending 48 TBI related questions to all radiotherapy clinics in Australia and New Zealand via the Australasian College of Physical Scientists in Medicine email distribution list. Centres not performing TBI were not expected to complete the survey and centres that had participated in a previous survey, or that were known to perform the treatment, were followed up if no response was received. Of a total of approximately 70 centres, 14 clinics responded to the survey. The vast majority of clinics use conventional lateral and/or anterior-posterior beams at extended SSD for TBI treatment delivery. However, treatment planning, ancillary equipment (used for immobilisation/modulation), beam energy and prescribed lung doses vary considerably-with some clinics delivering the prescription dose to the lungs and some aiming to deliver a lung dose which is lower than the prescription dose. Only one clinic reported using an advanced delivery technique with modulated arcs at extended SSD. Centres either said they had no access to outcome data or did not answer this question. Compared with an earlier survey from 2005, 3 clinics have lowered their linac dose rate and 7 are the same or similar. The TBI practice in Australia and New Zealand remains varied, with considerable differences in treatment planning, beam energy, accepted lung doses and delivered dose rates.