Detalhe da pesquisa
1.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Cell
; 187(10): 2446-2464.e22, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38582079
2.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell
; 185(4): 712-728.e14, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35063084
3.
Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope.
BMC Biol
; 19(1): 199, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34503506
4.
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.
J Biol Chem
; 294(50): 18952-18966, 2019 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578281
5.
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
J Neurosci
; 38(15): 3680-3688, 2018 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29540553
6.
Native PLGA nanoparticles attenuate Aß-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.
Sci Rep
; 14(1): 144, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167993
7.
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition.
bioRxiv
; 2024 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712164
8.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
bioRxiv
; 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38328219
9.
Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation.
ACS Chem Neurosci
; 14(24): 4282-4297, 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38054595
10.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
bioRxiv
; 2023 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961594
11.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
Res Sq
; 2023 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961627
12.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
bioRxiv
; 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37745431
13.
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nat Neurosci
; 26(5): 737-750, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37095396
14.
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
Nat Commun
; 13(1): 1969, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35413950
15.
Deciphering Network Crosstalk: The Current Status and Potential of miRNA Regulatory Networks on the HSP40 Molecular Chaperone Network.
Front Genet
; 12: 689922, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34234816
16.
Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability.
Cell Stress Chaperones
; 26(2): 443-452, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33547632
17.
Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects.
Biomolecules
; 10(11)2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33121065
18.
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Mol Neurodegener
; 15(1): 2, 2020 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31906970
19.
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Neuron
; 104(3): 458-470.e5, 2019 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31542321
20.
Therapeutic Strategies for Restoring Tau Homeostasis.
Cold Spring Harb Perspect Med
; 8(1)2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28159830