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1.
Hemodial Int ; 11 Suppl 3: S38-40, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17897110

RESUMO

A patient with end-stage renal disease on maintenance hemodialysis developed sudden severe abdominal pain and distension. He suffered a decline in his hematocrit and subsequent abdominal imaging revealed a large left-sided retroperitoneal hemorrhage in the setting of atrophic, severely cystic kidneys. He underwent selective left renal artery angiography and embolization due to continued hemorrhage with stabilization in his condition. However, he became paraparetic within hours of the embolization procedure due to spinal cord infarct. Acquired cystic kidney disease is a very common entity in patients with chronic kidney disease. Complications include cystic hemorrhage or infection, erythrocytosis, and renal cell carcinoma. Screening of patients for cystic disease and malignant transformation remains a controversial topic; however, most advocate abdominal imaging after 3 to 5 years on dialysis.


Assuntos
Hemorragia/etiologia , Doenças Renais Císticas/complicações , Espaço Retroperitoneal/patologia , Diagnóstico por Imagem , Embolização Terapêutica , Hemorragia/complicações , Hemorragia/terapia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Paraparesia/etiologia , Diálise Renal
2.
Int Urol Nephrol ; 44(2): 639-42, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21110092

RESUMO

A 61-year old African-American woman presented with abdominal pain, tender splenomegaly, anemia, and renal insufficiency. Bone marrow biopsy demonstrated systemic mastocytosis. She was treated with mediator-specific therapy and imatinib, but her renal and hepatic function deteriorated and she required maintenance hemodialysis. Renal biopsy demonstrated interstitial infiltration with mast cells and acute tubular necrosis. Acute kidney injury in the setting of systemic mastocytosis and imatinib therapy is discussed.


Assuntos
Injúria Renal Aguda/etiologia , Rim/patologia , Mastocitose Sistêmica/complicações , Oligúria/etiologia , Injúria Renal Aguda/diagnóstico , Injúria Renal Aguda/tratamento farmacológico , Antineoplásicos/uso terapêutico , Benzamidas , Biópsia , Medula Óssea/patologia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Seguimentos , Humanos , Mesilato de Imatinib , Mastocitose Sistêmica/diagnóstico , Mastocitose Sistêmica/tratamento farmacológico , Pessoa de Meia-Idade , Oligúria/diagnóstico , Oligúria/tratamento farmacológico , Piperazinas/uso terapêutico , Proteínas Tirosina Quinases/antagonistas & inibidores , Pirimidinas/uso terapêutico
3.
Cell Tissue Res ; 324(3): 403-10, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16505994

RESUMO

Vaults are abundant large ribonucleoprotein particles. They frequently colocalize with microtubules and accumulate in filamentous actin-rich lamellipodia. To examine the movement of vaults in living cells, a chimera between the green fluorescent protein and the major vault protein was created. This fusion protein assembled into vault particles as assayed by biochemical fractionation and direct observation of living or fixed cells. By fluorescence recovery after photobleaching, we analyzed the bulk transport of vault particles into neuritic tips of PC12 cells treated with nerve growth factor. Confocal laser scanning microscopy demonstrated co-localization of the major vault protein and microtubules. Video microscopy indicated that, whereas the majority of vault particles were stationary, some individual vault particles moved rapidly, consistent with the action of a microtubule-based or actin-based molecular motor.


Assuntos
Citoesqueleto/fisiologia , Proteínas de Fluorescência Verde/genética , Partículas de Ribonucleoproteínas em Forma de Abóbada/fisiologia , Animais , Transporte Biológico , Microscopia de Vídeo , Microtúbulos/fisiologia , Células PC12 , Ratos , Proteínas Recombinantes de Fusão/genética , Proteínas Recombinantes de Fusão/metabolismo , Partículas de Ribonucleoproteínas em Forma de Abóbada/genética , Partículas de Ribonucleoproteínas em Forma de Abóbada/metabolismo
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