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1.
Neuroradiology ; 59(3): 271-276, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28251327

RESUMO

INTRODUCTION: The Leo stent was the first retrievable stent for endovascular treatment of intracranial aneurysms (IAs). We report our experience with this device with emphasis on very long-term follow-up. METHODS: This study was approved by authors' ethical committee. A retrospective review of our prospectively maintained database identified all patients treated for a saccular IA with this stent in our institution. Technical issues and immediate and long-term outcomes (at least 12 months) were evaluated. RESULTS: Between 2004 and 2015, 50 patients with 52 IAs were identified. In two patients, the stent could not safely be placed (failure rate = 3.8%). Among 48 treated patients with 50 IAs, there were 44 women and 4 men (mean age, 53 years). Mean aneurysm diameter was 7.2 mm. All IAs but six were wide-necked. There was no immediate morbidity or mortality. Anatomical results included 76% complete occlusions, 22% neck remnants, and 2% incomplete occlusions. Mean follow-up was 50.2 months (range, 12-139 months). Two patients had delayed TIAs but long-term morbidity rate remained = 0%. At follow-up, occlusion was stable in 68% IAs, showed thrombosis in 12%, and recanalization in 20% IAs. Complementary treatment was required in 8% IAs. Final results showed 70% complete occlusions, 24% neck remnants, and 6% incomplete occlusions. Asymptomatic stent occlusion and significant stenosis occurred in one and two cases, respectively. CONCLUSION: The Leo stent is safe and effective for treatment of wide-necked saccular IAs. Very long-term results show high rates of adequate and stable occlusion. Moreover, the stent is well tolerated.


Assuntos
Procedimentos Endovasculares/métodos , Aneurisma Intracraniano/terapia , Stents , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Desenho de Prótese , Estudos Retrospectivos , Resultado do Tratamento
2.
Neuroradiology ; 59(3): 263-269, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28236050

RESUMO

INTRODUCTION: The p64 flow diverter (FD) device is a fully resheathable and detachable stent dedicated for endovascular treatment (EVT) of intracranial aneurysms (IAs). We report our mid-term experience with this device. METHODS: Between January 2015 and February 2016, we retrospectively identified, in our prospectively maintained database, all patients treated with p64 FDs in two institutions. Independent clinical follow-up was performed by a vascular neurologist. Imaging follow-up included a digitalized subtraction angiography (DSA) at 3, 6, and 12 months and a magnetic resonance angiography (MRA) at 12 months. RESULTS: Thirty-nine patients (22 women/17 men; median age 54 years) with 48 IAs (median aneurysm size 6.2 mm; mean neck size 3.4 mm) were identified. All IAs were saccular and unruptured. Failure of safe stent delivery occurred in 15% of cases (7/48 IAs) which were excluded. Transient neurological morbidity occurred in 2/35 patients (5.7%) including one delayed thromboembolic complication. No permanent morbidity or mortality was encountered. Complete aneurysmal occlusion at 3, 6, and 12 months was 20/30 (66.6%), 18/27 (66.6%), and 24/28 (85.7%), respectively. Intra-stent stenosis was observed in 9/29 patients (31%) and classified as moderate in 4/29 (13.7%) and mild in 5/29 patients (17.2%). These stenoses gradually improved over time, with only mild stenoses being identified at 6 months and at 12 months. CONCLUSION: In our small case series, the p64 FD stent appears safe and effective for EVT of IAs. A high occlusion rate and a low morbidity rate were observed.


Assuntos
Procedimentos Endovasculares/métodos , Aneurisma Intracraniano/terapia , Stents , Angiografia Digital , Angiografia Cerebral , Feminino , Humanos , Angiografia por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
3.
Neuroradiology ; 59(6): 619-624, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28401260

RESUMO

PURPOSE: Wide-neck bifurcation intracranial aneurysms (WNBA) with a branch incorporated in the aneurysm base remain difficult to treat by embolization. We aim to report our long-term follow-up of stent-assisted coiling (SAC) in this subgroup of patients. METHODS: This study was approved by our local ethical committee. A retrospective review of our prospectively maintained database identified all patients treated in our institution by SAC for a WNBA with a branch incorporated in the aneurysm base. Technical issues, immediate, long-term outcomes were evaluated. RESULTS: Between 2007 and 2015, 49 patients with 53 intracranial aneurysms (IAs) (52 unruptured, 1 ruptured) were identified and successfully treated. No morbidity/mortality occurred. The incorporated branch was preserved in all patients but one who was treated during a vasospasm phase. At the first 6-month imaging control, the branch was patent. Immediate occlusion was near-complete in 11/53 aneurysms (20.8%), neck remnant in 20/53 aneurysms (37.7%), and incomplete in 22/53 aneurysms (41.5%). Available imaging follow-up of 47 IAs, ranging from 3 to 84 months (mean 26 months ± 19.6 months), showed 27 progressive thrombosis (57.4%), 17 stable occlusions (36.2%), 1 minor recanalization (2.1%), and 2 significant recanalizations that were retreated (4.3%). The latest imaging control showed 30 near-complete occlusions (63.8%), 13 neck remnants (27.7%), and 4 incomplete occlusions (8.5%). CONCLUSION: Stent-assisted coiling is safe and effective for the treatment of WNBA with a branch incorporated in the aneurysm base. Despite poor immediate anatomical results, long-term follow-up shows a high rate of progressive thrombosis achieving adequate and stable occlusion in most patients.


Assuntos
Embolização Terapêutica/métodos , Aneurisma Intracraniano/terapia , Stents , Adulto , Idoso , Angiografia Cerebral , Feminino , Seguimentos , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Angiografia por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
4.
Alzheimers Dement ; 13(9): 1013-1023, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28263741

RESUMO

INTRODUCTION: Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. METHODS: Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. RESULTS: An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of -8.0% (95% credible interval: [-11.5, -5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (-8.5, CrI: [-11.5, -5.6]; -14.1, CrI: [-19.3, -8.8]; -10.6, CrI: [-14.6, -6.1], respectively). DISCUSSION: There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.


Assuntos
Doença de Alzheimer/diagnóstico , Doença de Alzheimer/patologia , Transtornos Cognitivos/etiologia , Diagnóstico por Computador , Hipocampo/patologia , Doença de Alzheimer/líquido cefalorraquidiano , Doença de Alzheimer/complicações , Peptídeos beta-Amiloides/líquido cefalorraquidiano , Transtornos Cognitivos/diagnóstico por imagem , Diagnóstico Diferencial , Progressão da Doença , Europa (Continente) , Feminino , Fluordesoxiglucose F18/metabolismo , Humanos , Masculino , Testes Neuropsicológicos , Fragmentos de Peptídeos/líquido cefalorraquidiano , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada de Emissão de Fóton Único , Proteínas tau/líquido cefalorraquidiano
5.
J Int Neuropsychol Soc ; 22(7): 744-54, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-27406061

RESUMO

OBJECTIVES: Mild cognitive impairment (MCI) has been associated with a high risk of conversion to Alzheimer's dementia. In addition to memory complaints, impairments in the visuospatial domain have been reported in this condition. We have previously shown that deficits in perceiving structure-from-motion (SFM) objects are reflected in functional reorganization of brain activity within the visual ventral stream. Here we aimed to identify structural correlates of psychophysical complex face and object recognition performance in amnestic MCI patients (n=30 vs. n=25 controls). This study was, therefore, motivated by evidence from recent studies showing that a combination of visual information across dorsal and ventral visual streams may be needed for the perception of three-dimensional (3D) SFM objects. METHODS: In our experimental paradigm, participants had to discriminate 3D SFM shapes (faces and objects) from 3D SFM meaningless (scrambled) shapes. RESULTS: Morphometric analysis established neuroanatomical evidence for impairment in MCI as demonstrated by smaller hippocampal volumes. We found association between cortical thickness and face recognition performance, comprising the occipital lobe and visual ventral stream fusiform regions (overlapping the known location of face fusiform area) in the right hemisphere, in MCI. CONCLUSIONS: We conclude that impairment of 3D visual integration exists at the MCI stage involving also the visual ventral stream and contributing to face recognition deficits. The specificity of such observed structure-function correlation for faces suggests a special role of this processing pathway in health and disease. (JINS, 2016, 22, 744-754).


Assuntos
Disfunção Cognitiva/fisiopatologia , Percepção de Profundidade/fisiologia , Reconhecimento Facial/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
6.
Neuroradiology ; 58(7): 665-71, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26945867

RESUMO

INTRODUCTION: The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is dedicated for endovascular treatment of wide-neck intracranial aneurysms located on small-diameter vessels (2-3.5 mm). This study reports midterm clinical and anatomical results of this device. METHODS: This study was approved by authors' ethical committees. A retrospective review of our prospectively maintained database identified all patients treated by this stent in three institutions. Technical issues and immediate and mid-term anatomical and clinical outcomes were evaluated. RESULTS: Forty patients (30 women/10 men, mean age of 55 years) with 43 aneurysms were identified. Mean aneurysm diameter was 5.6 mm (range, 2-13 mm). In all patients, treatment was successful and the stent could be precisely placed. There were three procedure-related complications, one stent thrombosis and two aneurysm ruptures, leading to immediate morbidity in one patient. Delayed ischemic events occurred in three patients including two transient attacks and one permanent deficit. The overall permanent morbidity rate was thus 5 %. No mortality occurred. Immediate aneurysm occlusion consisted of 36 complete occlusions (83.7 %), five neck remnants (11.6 %), and two incomplete occlusions (4.7 %). Twenty-seven patients (29 aneurysms) and 11 patients (11 aneurysms) had a 12- and 6-month angiographic follow-up, respectively. Final anatomical results included 36 complete occlusions (90 %) and four neck remnants (10 %). Two minor recanalizations were seen but did not require retreatment. Non-significant intrastent stenosis occurred in 7/40 followed-up cases (17.5 %). CONCLUSION: The LVIS Junior stent appears safe and effective for endovascular treatment of wide-neck intracranial aneurysms located on small vessels. Midterm results show high rates of adequate and stable occlusion.


Assuntos
Prótese Vascular , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/terapia , Angiografia por Ressonância Magnética/métodos , Stents , Angiografia Cerebral/métodos , Análise de Falha de Equipamento , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Miniaturização , Desenho de Prótese , Estudos Retrospectivos , Resultado do Tratamento
7.
BMC Neurol ; 14: 24, 2014 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-24495346

RESUMO

BACKGROUND: Subcortical hypodensities of presumed vascular etiology (SHPVO) are a clinical, radiological and neuropathological syndrome with a still largely unexplained pathophysiology. Parallel to the clinical heterogeneity, there is also recognised cerebral topographical diversity with undetermined etiological implications. Our aim is to assess clinical and neurosonological predictors of SHPVO according to their location. METHODS: Cross sectional analysis of consecutive patients that underwent neurosonologic evaluation and head CT within one month, during a one year period. We excluded patients with absent temporal sonographic window, any pathology with a possible confounding effect on cerebral arterial pulsatility, atrial fibrillation and other etiologies of white matter diseases. The mean pulsatility index (PI) of both middle cerebral arteries was measured in the middle third of the M1 segment; intima media thickness was evaluated in the far wall of both common carotid arteries. SHPVO were rated by analysis of head CT in deep white matter (DWMH), periventricular white matter (PVWMH) and basal ganglia (BGH). We conducted a multivariate ordinal logistic regression model including all clinical, demographic and ultrasonographic characteristics to determine independent associations with SHPVO. RESULTS: We included 439 patients, mean age 63.47 (SD: 14.94) years, 294 (67.0%) male. The independent predictors of SHPVO were age (OR = 1.067, 95% CI: 1.047-1.088, p < 0.001 for DWMH; OR = 1.068, 95% CI: 1.049-1.088, p < 0.001 for PVWMH; OR = 1.05, 95% CI: 1.03-1.071, p < 0.001 for BGH), hypertension (OR = 1.909, 95% CI: 1.222-2.981, p = 0.004 for DWMH; OR = 1.907, 95% CI: 1.238-2.938, p = 0.003 for PVWMH; OR = 1.775, 95% CI: 1.109-2.843, p = 0.017 for BGH) and PI (OR = 17.994, 95% CI: 6.875-47.1, p < 0.001 for DWMH; OR = 5.739, 95%CI: 2.288-14.397, p < 0.001 for PVWMH; OR = 11.844, 95% CI: 4.486-31.268, p < 0.001 for BGH) for all locations of SHPVO. CONCLUSIONS: Age, hypertension and intracranial pulsatility are the main independent predictors of SHPVO across different topographic involvement and irrespective of extracranial atherosclerotic involvement.


Assuntos
Encéfalo/diagnóstico por imagem , Espessura Intima-Media Carotídea , Ecoencefalografia , Fibras Nervosas Mielinizadas/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Idoso , Estudos Transversais , Ecoencefalografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Método Simples-Cego , Tomografia Computadorizada por Raios X/métodos
8.
Environ Technol ; 43(26): 4029-4041, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34092195

RESUMO

The development of this research was based on the analysis of an anaerobic fluidised bed reactor from the assembly of its components to the sealing of the system and further fluidisation. A hydrometer and a Venturi were used to identify the best means of measuring the flow rate. Results produced by both devices were similar, however, the latter was less effective due to the low flow rates necessary to operate the system. The hydrometer was the most adequate device for flow rate measurements in the range between 0.1 and 1.0 m³/h, whereas the Venturi proved to be an adequate device for the flow in the range between 0.3 and 0.7 m³/h. Sand with grain sizes varying from 357 to 1000 µm was used as support material. It was not observed statistically significant differences between the minimum fluidisation velocities related to the amount of supported material of 20% and 40% (VSM/Vusable) added to the reactor. Forty percent of the usable volume occupied with sand is adequate to reach fluidisation, instead of only the expansion of the bed. The fluidisation velocities for the sand grain size of 357 µm were 8.4 m/h ± 0.25 for 20%, and 8.6 m/h ± 0.30 for 40%, whereas for the 505 µm they were, respectively for 20% and 40%, 9.2 m/h ±0.70 and 10.1 m/h ± 0.37. The hydraulic tests allow to stress that sand grain sizes varying from 357 to 505 µm are recommended to be used in a system with similar characteristics.


Assuntos
Areia
9.
Int J Pediatr Adolesc Med ; 9(4): 186-189, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36937325

RESUMO

Behçet's disease (BD) is a rare systemic vasculitis with multisystemic involvement. Neurological involvement, called neuro-Behçet's disease (NBD), mostly involves the central nervous system and cerebral venous thrombosis (CVT) is the predominant neurological manifestation in the pediatric age. A 12-year-old female with a past medical history of a CVT, without an identifiable etiology, was admitted with a five-day right fronto-orbital headache. Neuroimage showed a subacute thrombosis of a right superficial sylvian vein, with indirect signs of intracranial hypertension and no imaging signs of vasculitis. Prothrombotic screening and immunologic study were normal. She was started on acetazolamide and hypocoagulation with progressively improving. She had a history of frequent oral aphthae and an episode of a genital ulcer three months before admission. Pathergy test was negative. HLA-B51 was positive. She was diagnosed with NBD and started therapy with colchicine and infliximab. After discharge, the patient remains without symptoms, hypocoagulated, and on infliximab regimen, without complications to report. This case, only diagnosed in the second episode of CVT, is paradigmatic of the difficulty in establishing the diagnosis of BD.

10.
J Clin Neurosci ; 88: 34-38, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33992200

RESUMO

BACKGROUND: APOE ε4 is independently associated with lobar intracranial hemorrhages (ICH). Although the ε4 allele enhances amyloid deposition in blood vessels, the ε2 allele predisposes to vasculopathic changes leading to rupture of amyloid laden vessels. Thus, ε4 and ε2 carriers might have increased susceptibility to ICH. We aimed to study the impact of the apolipoprotein E alleles in the development of symptomatic ICH (sICH). METHODS: We included 384 consecutive ischemic anterior circulation stroke patients submitted to thrombolysis between January 2014 and March 2016. Admission CT-scans were reviewed to calculate the ASPECTS. Patients were followed for up to at least 6 months post-stroke or until death. Outcome was development of sICH, defined according to the ECASS III. RESULTS: Considering APOE genotyping, three patients had ε2/ε2, four had ε2/ε4, 38 had ε2/ε3, 284 had ε3/ε3, 51 had ε3/ε4 and four had ε4/ε4. sICH was associated with sex and diabetes. In multivariate analysis, sICH was not associated with carrying one or more ε4 alleles (OR: 0.483, 95%CI = [0.059, 3.939], p = 0.497) nor with carrying one or more ε2 alleles (OR: 1.369, 95%CI = [0.278, 6.734], p = 0.699). CONCLUSION: No association was found between APOE genotype and the development of symptomatic intracranial hemorrhage.


Assuntos
Apolipoproteínas E/genética , Hemorragia Cerebral/etiologia , AVC Isquêmico/complicações , AVC Isquêmico/tratamento farmacológico , Ativador de Plasminogênio Tecidual/uso terapêutico , Idoso , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Terapia Trombolítica/métodos
11.
Braz J Cardiovasc Surg ; 35(6): 1017-1019, 2020 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-33306330

RESUMO

CASE PRESENTATION: A case of a 49-year-old patient, male, victim of stab wound, developing belatedly cardiac tamponade and hemodynamic stability was reported. The patient underwent a pericardial window with drainage of pericardial effusion of blackened aspect; however, without visualization of the cardiac lesion, enlargement of the incision by median sternotomy was opted for. A hematoma was spotted at the left ventricle with epicardial lesion and a patch of pericardium was made with 3-0 polypropylene. The patient developed acute pulmonary edema and atrial fibrillation, which improved after the intensive care unit clinical management, with hospital discharge in the 7th postoperative day.


Assuntos
Tamponamento Cardíaco , Derrame Pericárdico , Ferimentos Perfurantes , Tamponamento Cardíaco/diagnóstico por imagem , Tamponamento Cardíaco/etiologia , Tamponamento Cardíaco/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/diagnóstico por imagem , Derrame Pericárdico/etiologia , Derrame Pericárdico/cirurgia , Esternotomia , Ferimentos Penetrantes , Ferimentos Perfurantes/complicações , Ferimentos Perfurantes/cirurgia
12.
Arq Neuropsiquiatr ; 66(2B): 365-8, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18641873

RESUMO

We studied 386 cases of spinal cord injury to analyze the follow up of the patients admitted most of the time more than four hours, the majority of the injuries happening far from the attending health service and first specialized care received long after the accident. This is a clinical study based on data collected during hospitalization of the patients, operated or not, in a Brazilian public health service. The lesion mainly seen was fracture and dislocation, isolated or on multiple levels, and the most important clinical complications were due to respiratory failure and hypotension, especially because 73.8% were from outside and they were admitted more then four hours after the trauma. The mortality rate was 11.9%, but just 2.1% had undergone a surgery. The complications resulted in major risk of death when the trauma was at the cervical level and the patients were over 50 years old, especially when admitted more than four hours after the trauma. We emphasize the importance of the first health care concerning the clinical treatment, aiming to reduce the mortality rate.


Assuntos
Tratamento de Emergência/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Traumatismos da Medula Espinal/epidemiologia , Traumatismos da Medula Espinal/terapia , Acidentes por Quedas/estatística & dados numéricos , Acidentes de Trânsito/estatística & dados numéricos , Adolescente , Adulto , Brasil/epidemiologia , Serviços Médicos de Emergência/estatística & dados numéricos , Serviços Médicos de Emergência/provisão & distribuição , Feminino , Primeiros Socorros , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Motocicletas , Traumatismos da Medula Espinal/mortalidade , Fatores de Tempo , Transporte de Pacientes , População Urbana
13.
Neurology ; 89(1): 38-45, 2017 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-28566550

RESUMO

OBJECTIVE: To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS: We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education level. All participants underwent ToM testing (Eyes Test, Videos Test) and 3T brain MRI including conventional and diffusion tensor imaging sequences. Tract-based spatial statistics (TBSS) were applied for whole-brain voxel-wise analysis of fractional anisotropy (FA) and mean diffusivity (MD) on NAWM. RESULTS: Patients with MS performed worse on both tasks of ToM compared to HC (Eyes Test 58.7 ± 13.8 vs 81.9 ± 10.4, p < 0.001, Hedges g -1.886; Videos Test 75.3 ± 9.3 vs 88.1 ± 7.1, p < 0.001, Hedges g -1.537). Performance on ToM tests was correlated with higher values of FA and lower values of MD across widespread white matter tracts. The largest effects (≥90% of voxels with statistical significance) for the Eyes Test were body and genu of corpus callosum, fornix, tapetum, uncinate fasciculus, and left inferior cerebellar peduncle, and for the Videos Test genu and splenium of corpus callosum, fornix, uncinate fasciculus, left tapetum, and right superior fronto-occipital fasciculus. CONCLUSIONS: These results indicate that a diffuse pattern of NAWM damage in MS contributes to social cognition impairment in the ToM domain, probably due to a mechanism of disconnection within the social brain network. Gray matter pathology is also expected to have an important role; thus further research is required to clarify the neural basis of social cognition impairment in MS.


Assuntos
Esclerose Múltipla/diagnóstico por imagem , Esclerose Múltipla/fisiopatologia , Rede Nervosa/diagnóstico por imagem , Percepção Social , Teoria da Mente/fisiologia , Substância Branca/diagnóstico por imagem , Adulto , Imagem de Tensor de Difusão , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Rede Nervosa/fisiopatologia
14.
J Neurointerv Surg ; 8(9): 940-4, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26346460

RESUMO

BACKGROUND AND PURPOSE: The pCONus is a new stent featuring a distal end that opens like a blossoming flower with four petals. The device is implanted in the aneurysm sac at the level of the neck. We report our initial experience in a series of patients treated with this device. METHODS: This retrospective study was approved by the authors' ethics committees. 18 patients with 19 unruptured wide neck bifurcation intracranial aneurysms (IA) were treated by pCONus placement and coiling. Technical issues, immediate post treatment angiographic findings, and clinical and imaging follow-up were assessed. RESULTS: Embolization was successful in all patients. There were 11 women and 7 men with a mean age of 60 years. Median aneurysm size was 9 mm (range 5.5-25 mm). The device was precisely placed and detached in all cases, allowing for subsequent coiling. Two patients experienced a symptomatic complication, one of which, a thromboembolism, was related to the use of the pCONus. This patient had a slight hand paresis. 16 patients had a normal neurological examination at discharge. Immediate anatomical results were 13 complete occlusions, 2 neck remnants, and 4 incomplete occlusions. Imaging follow-up was obtained in 12 patients (mean 9.5 months, range 2-24 months) and showed 9 stable occlusions and 3 recanalizations, of which 2 were retreated. CONCLUSIONS: In this initial series of patients, endovascular treatment of wide neck bifurcation IAs with the pCONus was feasible, with acceptable clinical and anatomical outcomes. Further studies are needed to evaluate the indications, safety, and efficacy of this new device.


Assuntos
Embolização Terapêutica/métodos , Desenho de Equipamento , Aneurisma Intracraniano/terapia , Stents , Aneurisma/diagnóstico por imagem , Aneurisma/terapia , Angiografia Cerebral , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
15.
Expert Rev Med Devices ; 12(6): 753-62, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26415045

RESUMO

Flow diverter (FD) stents represent a new endovascular technique developed for the treatment of complex intracranial aneurysms (wide neck, fusiform, large, and giant aneurysms) that are challenging for classic endovascular techniques such as coiling, balloon-assisted coiling and stent-assisted coiling. Low porosity, high metal coverage, and high pore density are the main properties of FD stents. These properties induce hemodynamic changes redirecting the blood flow away from the aneurysm and into the parent artery leading to gradual thrombosis of the aneurysm. FD stents also provide scaffolding for subsequent neoendothelial proliferation, and vessel wall remodeling. This is considered as a paradigm shift compared to prior endovascular methods, which predominantly aimed at providing treatment inside the aneurysmal sac. This paper describes in detail the first released FD stent, the Silk flow-diverter stent (Balt Extrusion, Montmorency, France), its mechanism of action and deployment technique. It reviews the pertinent literature regarding safety, efficacy and potential risks and complications associated with the use of this stent.


Assuntos
Procedimentos Endovasculares , Aneurisma Intracraniano/terapia , Seda/química , Stents , Análise Custo-Benefício , Procedimentos Endovasculares/efeitos adversos , Procedimentos Endovasculares/economia , Humanos , Aneurisma Intracraniano/economia , Complicações Pós-Operatórias/etiologia
16.
Rev. bras. cir. cardiovasc ; 35(6): 1017-1019, Nov.-Dec. 2020. tab, graf
Artigo em Inglês | LILACS, SES-SP | ID: biblio-1144003

RESUMO

Abstract Case Presentation: A case of a 49-year-old patient, male, victim of stab wound, developing belatedly cardiac tamponade and hemodynamic stability was reported. The patient underwent a pericardial window with drainage of pericardial effusion of blackened aspect; however, without visualization of the cardiac lesion, enlargement of the incision by median sternotomy was opted for. A hematoma was spotted at the left ventricle with epicardial lesion and a patch of pericardium was made with 3-0 polypropylene. The patient developed acute pulmonary edema and atrial fibrillation, which improved after the intensive care unit clinical management, with hospital discharge in the 7th postoperative day.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/cirurgia , Derrame Pericárdico/etiologia , Derrame Pericárdico/diagnóstico por imagem , Tamponamento Cardíaco/cirurgia , Tamponamento Cardíaco/etiologia , Tamponamento Cardíaco/diagnóstico por imagem , Ferimentos Penetrantes , Ferimentos Perfurantes/cirurgia , Ferimentos Perfurantes/complicações , Esternotomia
17.
Arq Neuropsiquiatr ; 61(2B): 490-3, 2003 Jun.
Artigo em Português | MEDLINE | ID: mdl-12894292

RESUMO

Orbital injuries may be associated with the presence of foreign bodies in which long retention leads to damages such as loss of vision or cerebral abscess. We present the case of a 21-year-old male patient that developed ptosis, limitation of movements and an inflammatory reaction in the right eye after being hit by a tree branch. A CT scan of the orbits revealed an increased density in the right orbital cone. After the neurosurgical approach for the removal of the foreign body, a wooden fragment measuring 2.0x0.3 cm, the patient had a good outcome without visual deficits, ptosis regression and resolution of the inflammatory process. The postoperative CT scan didn't identify any remaining foreign body fragment. This case calls attention to the fact that the wooden splinter presented on CT scan with high density (136 HU) two months after the trauma and was removed by a supraorbital craniotomy.


Assuntos
Corpos Estranhos no Olho/complicações , Ferimentos Oculares Penetrantes/etiologia , Adulto , Corpos Estranhos no Olho/diagnóstico por imagem , Corpos Estranhos no Olho/cirurgia , Ferimentos Oculares Penetrantes/diagnóstico por imagem , Ferimentos Oculares Penetrantes/cirurgia , Humanos , Masculino , Tomografia Computadorizada por Raios X
18.
Arq Neuropsiquiatr ; 60(3-B): 844-6, 2002 Sep.
Artigo em Português | MEDLINE | ID: mdl-12364959

RESUMO

The authors report a case of neurocysticercosis by giant cyst (3.9 x 3.4 cm), where there were clinical manifestations of increased intracranial pressure and characteristics of image in computed tomography of cranium of expansive process with mass effect in central nervous system (CNS). They comment the possibility of the tumoral form of this disease having clinical and radiological presentation similar to other expansive processes of CNS and stress the surgical procedure as a form of treatment and diagnostic confirmation.


Assuntos
Neurocisticercose/diagnóstico , Adulto , Feminino , Humanos , Hipertensão Intracraniana/etiologia , Neurocisticercose/complicações , Neurocisticercose/cirurgia , Tomografia Computadorizada por Raios X
19.
Arq Neuropsiquiatr ; 61(1): 141-3, 2003 Mar.
Artigo em Português | MEDLINE | ID: mdl-12715040

RESUMO

Eosinophilic granuloma (EG) is a benign condition of histocytes proliferation localized or multifocal. It is presents in the cervical spine in 1.5%-20% of the cases of EG. We report the case of a seven-year-old girl that presented with a one month history of cervical pain, persistent wryneck and vicious posture of the neck. A computerized tomography was performed and confirmed the presence of spreading lesion, ostheodestructive to the level of the left laminae of C2, with invasion of the spine and the muscular tissue. A laminectomy was underwent for removal of the lesion. The patient had a good post-operative recovery with improvement of the symptoms. Chemotherapy with prednisone, vinblastine and ethoposide was administred. After six months, this protocol was repeated associaded to methotrexate. The patient improved and had no new symptoms in a follow-up of 36 months.


Assuntos
Vértebras Cervicais/diagnóstico por imagem , Granuloma Eosinófilo/diagnóstico por imagem , Doenças da Coluna Vertebral/diagnóstico por imagem , Criança , Granuloma Eosinófilo/complicações , Granuloma Eosinófilo/cirurgia , Feminino , Humanos , Doenças da Coluna Vertebral/complicações , Doenças da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X , Torcicolo/etiologia
20.
Arq Neuropsiquiatr ; 62(1): 162-6, 2004 Mar.
Artigo em Português | MEDLINE | ID: mdl-15122454

RESUMO

Schwannomas, neurinomas or neurilemmomas are benign peripheral nerve tumors. The literature report some cases associated with neurofibromatosis 2. We report two cases of cervical schwannoma originating from the brachial plexus unassociated with neurofibromatosis. A 31-year-old woman presented with a mass in the right supraclavicular region, irradiating pain and distal tingling to percussion (Tinel's sign) for 6 months. And a 52-year-old woman presented with pain in the cervical region and right arm for one year. Both the patients underwent to a microsurgery with total resection of the lesion. Histology of the surgical specimen confirmed the diagnosis of schwannoma. Postoperatively, the patients had a good recovery.


Assuntos
Plexo Braquial , Neurilemoma/diagnóstico , Neoplasias do Sistema Nervoso Periférico/diagnóstico , Adulto , Feminino , Humanos , Espectroscopia de Ressonância Magnética , Pessoa de Meia-Idade , Neurilemoma/patologia , Neurilemoma/cirurgia , Neoplasias do Sistema Nervoso Periférico/patologia , Neoplasias do Sistema Nervoso Periférico/cirurgia , Tomografia Computadorizada por Raios X
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