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Bioorg Med Chem Lett
; 28(12): 2143-2147, 2018 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29776742
RESUMO
N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising cellular activity and pharmacokinetic properties that make it a useful tool to study the biology of HDAC11 and its potential use as a therapeutic target for oncology and inflammation indications.