Detalhe da pesquisa
1.
Opioid prescriptions at the point of surgery, bone metastasis, or death among patients with breast cancer in Japanese acute care hospitals: a claims-based, retrospective, longitudinal study.
Support Care Cancer
; 31(6): 369, 2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37266722
2.
Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus.
Biol Pharm Bull
; 46(12): 1714-1719, 2023 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37853612
3.
Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone.
Am J Physiol Lung Cell Mol Physiol
; 323(2): L193-L205, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787697
4.
Involvement of the Peripheral µ-Opioid Receptor in Tramadol-Induced Constipation in Rodents.
Biol Pharm Bull
; 44(11): 1746-1751, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34719650
5.
Pharmacological Profile of Naldemedine, a Peripherally Acting µ-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol.
J Pharmacol Exp Ther
; 373(3): 438-444, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32169839
6.
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.
Bioorg Med Chem
; 25(7): 2177-2190, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284871
7.
The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice.
Pharmacology
; 99(5-6): 259-267, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28214870
8.
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.
Bioorg Med Chem Lett
; 26(20): 4936-4941, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27634196
9.
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.
Bioorg Med Chem Lett
; 26(20): 4930-4935, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27637151
10.
S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission.
Pharmacology
; 95(1-2): 95-103, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25721168
11.
Naldemedine and Magnesium Oxide as First-Line Medications for Opioid-Induced Constipation: A Comparative Database Study in Japanese Patients With Cancer Pain.
Cureus
; 16(3): e55925, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38601408
12.
The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty.
Sci Rep
; 14(1): 8943, 2024 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38637604
13.
High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan.
Neuropsychopharmacol Rep
; 2024 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38735866
14.
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.
Bioorg Med Chem
; 21(11): 3154-63, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623258
15.
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.
Bioorg Med Chem
; 21(7): 2045-55, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395112
16.
Real-World Evidence for the Safety and Effectiveness of Naldemedine in the Management of Opioid-Induced Constipation in Patients With Cancer Pain: Post-hoc Subgroup Analysis of Post-marketing Surveillance in Japan.
Cureus
; 15(9): e46090, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37900431
17.
A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer.
Pain Ther
; 12(4): 993-1003, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195398
18.
CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: reduction of CNS side effects by introducing polar functional groups.
Bioorg Med Chem Lett
; 22(8): 2894-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437111
19.
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.
Bioorg Med Chem Lett
; 22(8): 2803-6, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444677
20.
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent.
Bioorg Med Chem Lett
; 22(8): 2898-901, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22421019