Detalhe da pesquisa
1.
Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum.
J Biol Chem
; 298(5): 101933, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35427648
2.
Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit.
Mol Psychiatry
; 27(3): 1729-1741, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169261
3.
Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.
Brain
; 145(3): 950-963, 2022 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34528073
4.
Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.
Proc Natl Acad Sci U S A
; 117(1): 677-688, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871190
5.
KCC2 is required for the survival of mature neurons but not for their development.
J Biol Chem
; 296: 100364, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539918
6.
Direct Interaction of PP2A Phosphatase with GABAB Receptors Alters Functional Signaling.
J Neurosci
; 40(14): 2808-2816, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32111696
7.
Phosphorylation on Ser-359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
J Biol Chem
; 295(35): 12330-12342, 2020 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32620552
8.
Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures.
Proc Natl Acad Sci U S A
; 115(40): 10166-10171, 2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30224498
9.
GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.
Proc Natl Acad Sci U S A
; 115(40): E9479-E9488, 2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30228121
10.
Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation.
J Neurosci
; 39(19): 3611-3626, 2019 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30846615
11.
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors.
J Biol Chem
; 294(32): 12220-12230, 2019 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31239352
12.
Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses.
Proc Natl Acad Sci U S A
; 114(44): 11763-11768, 2017 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29078280
13.
Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway.
J Lipid Res
; 59(5): 830-842, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29563219
14.
Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome.
J Biol Chem
; 292(16): 6621-6632, 2017 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28213518
15.
N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.
J Biol Chem
; 292(52): 21253-21263, 2017 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29092909
16.
The dynamic modulation of GABA(A) receptor trafficking and its role in regulating the plasticity of inhibitory synapses.
Physiol Rev
; 91(3): 1009-22, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742794
17.
Compromising the phosphodependent regulation of the GABAAR ß3 subunit reproduces the core phenotypes of autism spectrum disorders.
Proc Natl Acad Sci U S A
; 112(48): 14805-10, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627235
18.
KCC2 activity is critical in limiting the onset and severity of status epilepticus.
Proc Natl Acad Sci U S A
; 112(11): 3523-8, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733865
19.
A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.
J Neurosci
; 36(11): 3106-14, 2016 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985023
20.
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.
J Biol Chem
; 291(23): 12394-407, 2016 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044742