Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 34
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
1.
Rev Med Liege ; 77(1): 45-51, 2022 Jan.
Artigo em Francês | MEDLINE | ID: mdl-35029340

RESUMO

Although physical activity is perceived as an effective therapeutic agent in the management of chronic diseases, the literature reports a low participation rate in adapted physical activity programmes and a high drop-out rate during participation. There is room for improvement in supporting the engagement of chronically ill patients in an active lifestyle, especially in optimising the process from medical management to integration into a local adapted sports structure. Based on the motivational principles of the self-determination theory, we propose courses of action to optimise the support of the chronically ill patient in the process of behavioural change. This article emphasises the importance of placing the individual at the centre of his or her physical care and the importance of taking into account individual characteristics in order to act on intrinsic motivation.


Bien que l'activité physique soit perçue comme un agent thérapeutique efficace dans la prise en charge des maladies chroniques, la littérature rapporte un faible taux de participation aux programmes d'activité physique adaptée ainsi qu'un taux élevé d'abandon lors de leur participation. Le soutien à l'engagement des malades chroniques vers un style de vie actif semble perfectible, notamment en optimisant le processus allant de la prise en charge médicale vers l'intégration au sein d'une structure sportive locale adaptée. En regard des principes motivationnels liés à la théorie de l'auto-détermination, nous proposons des pistes d'action permettant d'optimiser l'accompagnement du malade chronique lors de son processus de changement de comportement. Cet article met l'accent sur l'intérêt de placer l'individu au centre de sa prise en charge physique ainsi que sur l'importance de prendre en compte les caractéristiques individuelles afin d'agir sur sa motivation intrinsèque.


Assuntos
Exercício Físico , Motivação , Doença Crônica , Feminino , Humanos , Estilo de Vida , Masculino
2.
Res Q Exerc Sport ; 94(4): 1169-1182, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36624961

RESUMO

Purpose: Following increased interest in physical literacy (PL), development of appropriate tools for assessment has become an important next step for its operationalization. To forward the development of such tools, the objective of this study was to build the foundations of the Évaluation de la Littératie Physique (ELIP), designed to help reduce existing tensions in approaches to PL assessment that may be resulting in a low uptake into applied settings. Methods: We followed two steps: (1) the development of the first version of ELIP by deploying a Delphi method (n = 30); and (2) the modification of items through cognitive interviews with emerging adults (n = 32). Results: The expert consensus highlighted four dimensions of PL to be assessed-physical; affective; cognitive; and social-with new perspectives, including a preference for broad motor tests over fitness. Conclusion: Results offer new insights into the assessment of emerging adults' PL, but ELIP still requires further work concerning validity, reliability, and sensitivity.


Assuntos
Letramento em Saúde , Humanos , Adulto , Reprodutibilidade dos Testes , Exercício Físico
3.
Alzheimers Res Ther ; 14(1): 64, 2022 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-35538502

RESUMO

BACKGROUND: The primary progressive aphasia (PPA) diagnosis trajectory is debated, as several changes in diagnosis occur during PPA course, due to phenotype evolution from isolated language alterations to global cognitive impairment. The goal of the present study, based on a French cohort, was to describe the demographics and the evolution of subjects with (PPA) in comparison with Alzheimer's disease (AD) on a period of 7 years. METHODS: We conducted a repeated cross-sectional study. The study population comprised individuals with PPA and AD diagnosis (N=167,191) from 2010 to 2016 in the French National data Bank (BNA). Demographic variables, MMSE scores, diagnosis status at each visit and prescribed treatments were considered. RESULTS: From 2010 to 2016, 5186 patients were initially diagnosed with PPA, 162,005 with AD. Compared to AD subjects, significant differences were found concerning age (younger at first diagnosis for PPA), gender (more balanced in PPA), education level (higher in PPA) and MMSE score (higher of 1 point in PPA). Percentage of pending diagnosis, delay between first consultation and first diagnosis and the number of different diagnoses before the diagnosis of interest were significantly higher in PPA group compared to AD group. Pharmacological and non-pharmacological treatments were significatively more recommended following PPA than AD diagnosis. CONCLUSION: This study improves the knowledge of PPA epidemiology and has the potential to help adopting appropriate public health service policies. It supports the hypothesis that PPA is diagnosed later than AD. The PPA diagnosis increases the prescription of non-pharmacological treatments, especially speech and language therapy (SLT) that is the main treatment available and most effective when at the initial stage. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT03687112.


Assuntos
Doença de Alzheimer , Afasia Primária Progressiva , Doença de Alzheimer/diagnóstico , Doença de Alzheimer/epidemiologia , Doença de Alzheimer/terapia , Afasia Primária Progressiva/diagnóstico , Afasia Primária Progressiva/epidemiologia , Afasia Primária Progressiva/terapia , Estudos Transversais , Diagnóstico Diferencial , Humanos , Idioma
4.
Life Sci ; 245: 117330, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31962130

RESUMO

AIMS: The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS: Adult male Wistar rats were exposed to ethanol (EtOH) vapor inhalation for 16 weeks. Echocardiography was performed to assess terminal cardiac structure and function. Cardiac fibroblasts were isolated from the left ventricle (LV) for both ex vivo and in vitro analysis. Cultured H9C2 cells were also exposed to conditioned media from alcohol-exposed cardiac fibroblasts. Gene expression in whole LV tissue, isolated cardiac fibroblasts, or cultured H9C2 cells was determined by real-time PCR, and protein expression was determined by Western blot. KEY FINDINGS: EtOH led to LV wall thinning and impaired systolic function, and decreased contractile protein mRNA levels. EtOH increased LV inflammatory markers, JNK and Akt activation, and decreased mTOR expression. EtOH induced myofibroblast activation as assessed by flow cytometry, and increased LV collagen III expression. EtOH increased expression of several inflammatory mediators in cardiac fibroblasts both ex vivo and in vitro. Administration of conditioned media from EtOH-treated fibroblasts decreased contractile protein mRNA levels and impaired Akt and mTOR signaling in differentiated H9C2 cardiomyocytes. SIGNIFICANCE: Our results indicate that EtOH-induced cardiac atrophy and dysfunction is associated with activation of inflammatory pathways. Furthermore, EtOH may induce a pro-inflammatory cardiac fibroblast phenotype, leading to aberrant fibroblast-myocyte cross-talk. Thus, EtOH may promote cardiac muscle wasting in part by activation of pro-inflammatory fibroblasts.


Assuntos
Etanol/efeitos adversos , Coração/efeitos dos fármacos , Miocárdio/patologia , Animais , Atrofia , Western Blotting , Cardiomiopatias/induzido quimicamente , Cardiomiopatias/patologia , Cardiomiopatias/fisiopatologia , Ecocardiografia , Fibroblastos/efeitos dos fármacos , Fibroblastos/patologia , Coração/fisiopatologia , Inflamação/induzido quimicamente , Inflamação/patologia , Masculino , Miocárdio/citologia , Ratos , Ratos Wistar , Reação em Cadeia da Polimerase em Tempo Real , Remodelação Ventricular/efeitos dos fármacos
7.
Prog Urol ; 18(5): 318-22, 2008 May.
Artigo em Francês | MEDLINE | ID: mdl-18538278

RESUMO

OBJECTIVE: To review the various clinical forms of female urethral cancer in the light of three clinical cases with a review of the corresponding treatment guidelines. METHOD: The authors report three cases of female urethral cancer. Case 1 consisted of squamous cell carcinoma in a 56-year-old woman with no particular history. Case 2 was a urothelial tumour arising in a urethral diverticulum in a 60-year-old smoker. Case 3 was a 69-year-old woman patient with invasive urothelial carcinoma. RESULTS: Case 1 was treated by segmental urethrectomy with no adjuvant therapy and a favourable course. Case 2 was treated by anterior pelvic exenteration with no adjuvant therapy. This patient relapsed in the form of peritoneal carcinomatosis two years later and died. Case 3 was initially treated by anterior pelvic exenteration followed by a chemoradiotherapy combination after local recurrence with a favourable course. CONCLUSION: There are many clinical presentations and histological forms of female urethral cancer. Localized distal lesions can be treated by simple circumferential resection. The treatment of other lesions comprises anterior pelvic exenteration and platinum- or M-VAC-based chemoradiotherapy. The main prognostic factors for these tumours are their size, histological type, site and the presence of pelvic lymph node extension.


Assuntos
Carcinoma/cirurgia , Neoplasias Uretrais/cirurgia , Idoso , Carcinoma/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/terapia , Neoplasias Uretrais/patologia
8.
Alzheimers Res Ther ; 10(1): 92, 2018 09 12.
Artigo em Inglês | MEDLINE | ID: mdl-30208961

RESUMO

BACKGROUND: Gender distribution varies across neurodegenerative disorders, with, traditionally, a higher female frequency reported in Alzheimer's disease (AD) and a higher male frequency in Parkinson's disease (PD). Conflicting results on gender distribution are reported concerning dementia with Lewy bodies (DLB), usually considered as an intermediate disease between AD and PD. The aim of the present study was to investigate gender differences in DLB in French specialized memory settings using data from the French national database spanning from 2010 to 2015 and to compare sex ratio in DLB with that in AD, Parkinson's disease dementia (PDD), and PD. Our hypothesis was that there is a balanced sex ratio in DLB, different from that found in AD and PD. METHODS: We conducted a repeated cross-sectional study. The study population comprised individuals with a DLB, AD, PDD, or PD diagnosis according to the International Classification of Diseases, Tenth Revision, in the French National Alzheimer Database between 2010 and 2015. Sex ratio and demographic data were compared using multinomial logistic regression and a Bayesian statistical model. RESULTS: From 2010 to 2015 in French specialized memory settings, sex ratios (female percent/male percent) were found as follows: 1.21 (54.7%/45.3%) for DLB (n = 10,309), 2.34 (70.1%/29.9%) for AD (n = 135,664), 0.76 (43.1%/56.9%) for PD (n = 8744), and 0.83 (45.4%/54.6%) for PDD (n = 3198). Significant differences were found between each group, but not between PDD and PD, which had a similar sex ratio. CONCLUSIONS: This large-sample prevalence study confirms the balanced gender distribution in the DLB population compared with AD and PD-PDD. Gender distribution and general demographic characteristics differed between DLB and PDD. This is consistent with the hypothesis that DLB is a distinct disease with characteristics intermediate between AD and PD, as well as with the hypothesis that DLB could have at least partially distinct neuropathological correlates.


Assuntos
Doença de Alzheimer/epidemiologia , Doença por Corpos de Lewy/epidemiologia , Doença de Parkinson/epidemiologia , Razão de Masculinidade , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Masculino , Memória , Fatores Sexuais
9.
Rev Neurol (Paris) ; 163(1): 138-41, 2007 Jan.
Artigo em Francês | MEDLINE | ID: mdl-17304183

RESUMO

Paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli disease) is a rare acquired clonal disorder of the hematopoietic stem cell. Its most frequent clinical manifestations are hemolytic crisis and the most serious are venous thrombosis of the mesenteric, hepatic, portal or cerebral territories. Arterial cerebral infarctions are extremely rare. We report and comment on a case of multiple strokes occurring during an hemolytic crisis and despite effective long-term anticoagulation treatment.


Assuntos
Infarto Cerebral/etiologia , Hemoglobinúria Paroxística/complicações , Adulto , Humanos , Masculino
10.
Infect Genet Evol ; 52: 10-18, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28412525

RESUMO

Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome. We also detected a large proportion of individuals infected by Bartonella vinsonii arupensis, a human pathogenic bacteria responsible for endocarditis, as well as Borrelia burgdorferi, the pathogen responsible for Lyme disease in North America. We then compared the microbiomes among two P. leucopus genetic clusters occurring on either side of the St. Lawrence River, and did not detect any effect of the host genotype on their liver microbiome assemblage. Finally, we report, for the first time, the presence of B. burgdorferi in a small mammal host from the northern side of the St. Lawrence River, in support of models that have predicted the northern spread of Lyme disease in Canada.


Assuntos
Reservatórios de Doenças/microbiologia , Fígado/microbiologia , Microbiota , Peromyscus/microbiologia , Análise de Sequência de DNA/métodos , Animais , Bartonella/isolamento & purificação , Borrelia burgdorferi/isolamento & purificação , Canadá , DNA Ribossômico/análise , Lactobacillus/isolamento & purificação , América do Norte , RNA Ribossômico 16S/análise
11.
Gait Posture ; 54: 56-61, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28259040

RESUMO

BACKGROUNDS: The aim of this study was to assess the relationship between the level of ambulatory physical activity, measured by physical activity tracker, and the clinical components of physical frailty, among nursing home residents. METHODS: We proceeded in 3 steps: (1) Validation of the physical activity tracker (i.e. the Pebble): 24 volunteer adults walked on a treadmill. The number of steps recorded by the Pebble worn by the subjects was compared with the number of steps counted by the investigators, by means of the Intra-class correlation coefficients (ICC). (2) Measurement of ambulatory physical activity, using the Pebble trackers, over a 7-day period. (3) Relationship between the results obtained with the Pebble trackers (step 2) and subjects' clinical characteristics, linked to physical frailty. RESULTS: ICC data, showed that the reliability of the Pebble was better when it was worn at the foot level (ICC ranged from 0.60 to 0.93 depending on the tested speed). Gait speed is also an important determinant of the reliability, which is better for low gait speed. On average, the 27 nursing home residents included in the second step of this study walked 1678.4±1621 (median=1300) steps per day. Most physical components of frailty measured in this study were significantly different between subjects who walked less than 1300 steps per day and those who were more active. CONCLUSION: This study showed that nursing home residents have a poor ambulatory physical activity, assessed using a physical activity tracker, which is associated with poorer physical performances and higher disability.


Assuntos
Exercício Físico , Idoso Fragilizado , Instituição de Longa Permanência para Idosos , Casas de Saúde , Caminhada , Idoso , Estudos Transversais , Feminino , Monitores de Aptidão Física , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes
12.
Best Pract Res Clin Obstet Gynaecol ; 19(4): 631-44, 2005 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16150396

RESUMO

Treatment for cervical cancer is very successful, especially in early stages. However, most patients presenting in late stages of disease will experience recurrence. The prognosis of recurrent disease is very poor and treatment options are limited. The diagnosis of recurrence may be apparent or difficult, but determining the extent of disease is always complex. Routine follow-up of asymptomatic patients has other objectives and is not a reliable way to detect recurrences. Symptomatic patients require extensive investigation to detect the extent of the disease. For patients with central pelvic recurrences, exenteration offers the prospect of survival in more than one-third of cases. Newer developments include laterally extended endopelvic resection that may become an option for patients with more extensive pelvic recurrence. For patients with recurrences of cervical cancer, the roles of second-time radiotherapy or postradiation chemotherapy are very limited. Palliative treatment is important for all patients with untreatable disease. Pain relief forms a central part of palliative care. Caregivers also experience emotional feelings and probably function best in a system offering strong colleageal support.


Assuntos
Recidiva Local de Neoplasia/cirurgia , Neoplasias do Colo do Útero/cirurgia , Feminino , Humanos , Histerectomia , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/radioterapia , Exenteração Pélvica/métodos , Assistência Terminal/métodos , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias do Colo do Útero/radioterapia
13.
Orthop Traumatol Surg Res ; 101(6 Suppl): S217-20, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26278024

RESUMO

INTRODUCTION: The number of outpatient surgical procedures performed in France on the forefoot has grown rapidly in recent years. OBJECTIVES: The goal of this study was to evaluate experience and satisfaction of patients undergoing outpatient foot surgery using a telephone questionnaire developed for this purpose. MATERIAL AND METHODS: In 2012 and 2013, every patient who was admitted to the day surgery unit at our hospital for an open procedure on their forefoot was called the morning after the procedure. A nurse went through the 14-item questionnaire with the patient. The same perioperative protocol, written instructions and treatment were used for all patients. RESULTS: Six hundred nineteen patients were included. The questionnaire response rate was 89% (n=540). Isolated hallux valgus surgery was performed on 319 patients (61%); 107 patients (20%) underwent hallux valgus surgery with lateral metatarsal osteotomy; 57 patients (10.5%) underwent first metatarsophalangeal fusion and 47 patients (8.5%) underwent a procedure on the lateral rays only. In the postoperative phase, 65% reported having satisfactory sleep quality, 32% had experienced nausea, 16% had experienced vomiting and 17% had experienced bleeding. Eighty percent of patients experienced pain (VAS ≥ 1); 80% of these patients had their pain relieved by the prescribed treatment and 4% had not taken it. Nearly all the patients (99%) were satisfied with the outpatient care; the overall satisfaction score was 9.4 out of 10. There was a significant relationship between the type of procedure and vomiting, pain, bleeding and fever. DISCUSSION: Outpatient care is becoming more common in response to economic challenges. The development of outpatient foot surgery appears to have satisfied the vast majority of operated patients. However, adjustments should be made to improve their tolerance to the pain management protocol. Although the logistics of performing follow-up call can be complicated, the patients appreciate receiving this call the next day. The call also seems to reassure both the patients and care providers.


Assuntos
Procedimentos Cirúrgicos Ambulatórios/normas , Artrodese/métodos , Antepé Humano/cirurgia , Hallux Valgus/cirurgia , Pacientes Ambulatoriais/psicologia , Satisfação do Paciente , Feminino , Humanos , Masculino , Período Pós-Operatório , Inquéritos e Questionários
14.
Am J Psychiatry ; 149(11): 1543-8, 1992 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-1415823

RESUMO

OBJECTIVE: The authors examined the relationship between negative symptoms and premorbid variables in drug-free schizophrenic patients. METHOD: The authors studied 63 clinically stable male schizophrenic inpatients who were not receiving any psychoactive medication. The patients were classified as having negative, positive, or mixed symptoms, and their premorbid functioning during childhood, early adolescence, and late adolescence was assessed by using the Premorbid Adjustment Scale. Correlational analyses were applied to the classification and developmental models. RESULTS: Patients with negative symptoms had significantly lower levels of premorbid functioning during late adolescence and significantly greater premorbid deterioration between childhood and early adolescence. Correlational analysis revealed significant positive relationships between premorbid variables and negative symptoms. CONCLUSIONS: The data suggest that a deterioration in social and intellectual functioning between childhood and adolescence is associated with the development of a negative symptom syndrome in schizophrenia. The premorbid deterioration appears to be an early prodrome of the disorder. Whether this residual negative symptom syndrome is in some way related to the deficit syndrome of schizophrenia awaits a prospective study.


Assuntos
Esquizofrenia/diagnóstico , Psicologia do Esquizofrênico , Ajustamento Social , Adulto , Fatores Etários , Estudos Transversais , Escolaridade , Hospitalização , Humanos , Masculino , Modelos Psicológicos , Escalas de Graduação Psiquiátrica , Estudos Retrospectivos
15.
Am J Med ; 99(6): 611-5, 1995 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7503083

RESUMO

OBJECTIVE: To assess the plasma arterial catecholamine response to nocturnal desaturation in a group of patients with a history suggestive of sleep apnea. PATIENTS AND METHODS: At a Veterans Affairs hospital, 10 patients who had a history consistent with sleep apnea syndrome were involved in the study. Arterial plasma catecholamines were measured at varying intervals during a 5 1/2-hour sleep study. Eighteen samples per patient were analyzed. RESULTS: As the hemoglobin saturation decreased, the variability in plasma norepinephrine increased significantly (r = -.78, P = 0.004). As the hemoglobin saturation fell, there was a trend towards higher concentrations of plasma norepinephrine (r = -.53, P = 0.06). As the hemoglobin saturation decreased, the variability in plasma epinephrine concentration was not significant (r = .42). CONCLUSION: The association between the degree of desaturation and the variability in norepinephrine suggests that norepinephrine is released in response to nocturnal desaturation.


Assuntos
Norepinefrina/sangue , Síndromes da Apneia do Sono/sangue , Adulto , Idoso , Dióxido de Carbono/sangue , Hemoglobinas/metabolismo , Humanos , Pessoa de Meia-Idade , Oximetria , Oxigênio/sangue , Polissonografia , Testes de Função Respiratória , Fatores de Tempo
16.
Sleep ; 15(6): 519-25, 1992 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-1475566

RESUMO

Delta sleep-inducing-peptide (DSIP) has been reported to increase sleep in subjects with insomnia. The authors studied cerebrospinal fluid (CSF) DSIP-like immunoreactivity (DSIP-LI) in 15 drug-free male subjects with a DSM-IIIR diagnosis of schizophrenia. The subjects underwent a lumbar puncture and three nights of polysomnography. CSF DSIP-LI was significantly correlated with polysomnography the night before the LP: with stage 3 sleep (p = 0.05), stage 3 and delta (stages 3 + 4) sleep during the first nonrapid eye movement NREM period (p = 0.02 and p = 0.05, respectively) and the ratio of the first and second NREM period (p < 0.05), and negatively with stage 2% sleep (p < 0.05). Whether this first report of a potential relationship between CSF DSIP-LI and slow-wave sleep in man might be generalized to sleep in nonpsychiatric subjects awaits further study.


Assuntos
Ritmo Delta , Peptídeo Indutor do Sono Delta/líquido cefalorraquidiano , Esquizofrenia/líquido cefalorraquidiano , Psicologia do Esquizofrênico , Fases do Sono/fisiologia , Adulto , Humanos , Masculino , Polissonografia , Radioimunoensaio , Tempo de Reação/fisiologia , Esquizofrenia/diagnóstico , Sono REM/fisiologia , Vigília
17.
Int J Food Microbiol ; 94(1): 33-42, 2004 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-15172483

RESUMO

Canned truffle products labeled Tuber melanosporum, the famous Perigord truffle, may contain other less tasty and cheaper truffle species. To protect consumers from fraud, a PCR DNA-based method was used to unequivocally identify the nature of the product. Several rapid and simple cell lysis procedures, used in conjunction with a commercially available DNA purification kit, were evaluated for their effectiveness in recovering DNA from canned truffle. In parallel, a marker for T. melanosporum was tested on the mitochondrial rDNA. These two techniques were then combined to differentiate T. melanosporum from other truffle species like T. aestivum, T. brumale or T. indicum up to the legal threshold in canned products. These findings not only allow a comparison of the effectiveness of the different DNA extraction methods but also provide a preliminary indication of the specificity and sensitivity of the detection with the mitochondrial marker that might be attainable for truffle species in a quantitative PCR-based analysis method.


Assuntos
Ascomicetos/classificação , DNA Fúngico/genética , Contaminação de Alimentos/análise , Reação em Cadeia da Polimerase/métodos , Ascomicetos/genética , DNA Mitocondrial/genética , DNA Ribossômico/genética , Contaminação de Alimentos/prevenção & controle , Conservação de Alimentos , Tecnologia de Alimentos , Polimorfismo de Fragmento de Restrição , Sensibilidade e Especificidade
18.
Psychiatry Res ; 42(1): 53-63, 1992 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-1603881

RESUMO

Chromogranin A (CgA) is a calcium binding protein and a precursor of modulatory peptides in the brain. We measured CgA-like immunoreactivity (CgA-LI) in cerebrospinal fluid (CSF) in 15 male schizophrenic patients (diagnosed by DSM-III-R criteria) after 3 nights of polysomnography. Patients had been drug free for at least 33 days. Our earlier report that CSF CgA-LI in schizophrenic patients correlated significantly with negative symptoms and ventricle-brain ratios, which have been related to slow wave sleep, raised the possibility that CgA-LI might relate to slow wave sleep. CSF CgA-LI was significantly correlated with stage 4 sleep and rapid eye movement latency. Whether these positive relationships between CSF CgA-LI and electroencephalographic sleep measures are specific for schizophrenia awaits further study.


Assuntos
Cromograninas/líquido cefalorraquidiano , Eletroencefalografia , Tempo de Reação/fisiologia , Esquizofrenia/líquido cefalorraquidiano , Psicologia do Esquizofrênico , Fases do Sono/fisiologia , Sono REM/fisiologia , Adulto , Cromogranina A , Humanos , Masculino , Radioimunoensaio
19.
Sante Publique ; 9(2): 235-53, 1997 Jun.
Artigo em Francês | MEDLINE | ID: mdl-9417378

RESUMO

With the aim of helping physicians working in a "Mother and Infant Protection Service" (PMI) in their mission of children's development difficulties screening, authors tried to assess performances of a clinical tool including parental informations and standardized tests. The whole four years old children going at school in a canton of Calvados department were independently examined by a PMI doctor using the tool to be estimated and by a specialized service working from a beforehand established protocol. For the language disorders on the one hand and the adaptation on the other hand, this evaluation shows a significant correlation between the PMI screening and the specialists one's: the sensitivity of the PMI examination is about 70% for those two types of difficulties with a positive predictive value respectively 28% and 57%. However the tool appears less reliable for the psychomotor disorders screening: only one quarter of the children who require a specialized investigation about these problems have been detected by the PMI screening. A filing and a selection of the questionnaire items should permit to improve the efficiency of this tool.


Assuntos
Deficiências do Desenvolvimento/diagnóstico , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos Psicomotores/diagnóstico , Inquéritos e Questionários , Pré-Escolar , Estudos de Avaliação como Assunto , Humanos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA