Detalhe da pesquisa
1.
The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
Bioorg Med Chem Lett
; 25(19): 4136-42, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298499
2.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466188
3.
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(17): 5714-20, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22832322
4.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett
; 22(15): 4967-74, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765895
5.
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg Med Chem Lett
; 21(7): 2064-70, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376583
6.
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
J Med Chem
; 56(11): 4320-42, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23701517
7.
Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
J Med Chem
; 56(24): 10003-15, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24294969
8.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22548365
9.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22897589
10.
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.
J Med Chem
; 54(13): 4735-51, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21612232
11.
Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.
J Med Chem
; 54(14): 5174-84, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21714526
12.
Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.
J Med Chem
; 54(6): 1789-811, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21332118
13.
A phthalide with in vitro growth inhibitory activity from an oidiodendron strain.
J Nat Prod
; 67(12): 2086-9, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15620258