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BMC Physiol ; 2: 1, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-11818034

RESUMO

BACKGROUND: Iron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger and more distensible, and 3) the beta-blocker propanolol would reduce hypertrophy. METHODS: 1) 30 CD rats were fed an ID or replete diet for 1 week or 1 month. Norepinephrine was infused via jugular vein; pressure was monitored at carotid artery. Saline infusions were used as a control. The pressure trace was analyzed for HR, contractility, systolic and diastolic pressures. 2) Abdominal aorta catheters inflated the aorta, while digital microscopic images were recorded at stepwise pressures to measure arterial diameter and distensibility. 3) An additional 10 rats (5 ID, 5 control) were given a daily injection of propanolol or saline. After 1 month, the hearts were excised and weighed. RESULTS: Enhanced contractility, but not HR, was associated with ID hypertrophic hearts. Systolic and diastolic blood pressures were consistent with an increase in arterial diameter associated with ID. Aortic diameter at 100 mmHg and distensibility were increased with ID. Propanolol was associated with an increase in heart to body mass ratio. CONCLUSIONS: ID cardiac hypertrophy results in an increased inotropic, but not chronotropic response to the sympathetic neurotransmitter, norepinephrine. Increased aortic diameter is consistent with a flow-dependent vascular remodeling; increased distensibility may reflect decreased vascular collagen content. The failure of propanolol to prevent hypertrophy suggests that ID hypertrophy is not mediated via beta-adrenergic neurotransmission.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Artérias/patologia , Cardiomegalia/etiologia , Coração/fisiopatologia , Deficiências de Ferro , Norepinefrina/farmacologia , Propranolol/uso terapêutico , Adaptação Fisiológica , Animais , Artérias/fisiopatologia , Peso Corporal , Cardiomegalia/fisiopatologia , Cardiomegalia/prevenção & controle , Elasticidade , Coração/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Hematócrito , Hemodinâmica , Masculino , Contração Miocárdica/efeitos dos fármacos , Miocárdio/patologia , Tamanho do Órgão , Ratos
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