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2.
Arch Virol ; 164(6): 1515-1525, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30887229

RESUMO

Rotaviruses and noroviruses are the most important viral causes of acute gastroenteritis in children. While previous studies of acute gastroenteritis in Indonesia mainly focused on rotavirus, here, we investigated the burden and epidemiology of norovirus and rotavirus disease. Children less than five years of age hospitalized with acute gastroenteritis were enrolled in this study from January to December 2015 at three participating hospitals. Rotavirus was detected by enzyme immunoassay (EIA), followed by genotyping by reverse transcription PCR (RT-PCR). Norovirus genogroups were determined by TaqMan-based quantitative RT-PCR. Among 406 enrolled children, 75 (18.47%), 223 (54.93%) and 29 (7.14%) cases were positive for norovirus, rotavirus and both viruses (mixed infections), respectively. Most cases clinically presented with fever, diarrhea, vomiting and some degree of dehydration. The majority (n = 69/75 [92%]) of the noroviruses identified belonged to genogroup II, and several genotypes were identified by sequencing a subset of samples. Among 35 samples tested for rotavirus genotype, the most prevalent genotype was G3P[8] (n = 30/35 [85.6%]). Our study suggests that the burden of norovirus diseases in Indonesian children should not be underestimated. It also shows the emergence of rotavirus genotype G3P[8] in Indonesia.


Assuntos
Infecções por Caliciviridae/diagnóstico , Gastroenterite/virologia , Norovirus/classificação , Infecções por Rotavirus/diagnóstico , Rotavirus/classificação , Pré-Escolar , Fezes/virologia , Feminino , Técnicas de Genotipagem/métodos , Hospitalização , Humanos , Indonésia , Lactente , Masculino , Norovirus/genética , Norovirus/isolamento & purificação , Filogenia , Rotavirus/genética , Rotavirus/isolamento & purificação , Análise de Sequência de RNA/métodos
3.
J Infect Dis ; 200 Suppl 1: S188-94, 2009 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-19821711

RESUMO

Globally, rotavirus is the leading cause of diarrhea-related hospitalizations and deaths among young children, but the burden of rotavirus disease in Indonesia is poorly documented. From January through December 2006, we conducted prospective surveillance (inpatient and outpatient) among children aged <5 years at 6 hospitals in 6 provinces of Indonesia, using standardized methodology. Of 2240 enrolled children hospitalized for diarrhea, 1345 (60%) were rotavirus positive. Of 176 children enrolled in outpatient clinics in 3 hospitals, 73 (41%) were rotavirus positive. Among children hospitalized for diarrhea, dehydration was more common among those who tested positive for rotavirus than among those who did not (91% vs 82%; P < .05), as was vomiting (86% vs 67%; P < .05). Children aged 6-23 months experienced 72% of all rotavirus episodes. Rotavirus prevalence increased slightly in the cool, dry season. The most commonly detected genotypes were G9 (30%) and P[6] (56%). G1P[6] and G9P[6] accounted for 34% and 21% of strains, respectively. A high proportion of genotype P[6] was detected, in combination with the common G types G1 and G9. Available rotavirus vaccines would likely be efficacious against the most common circulating strains, but continued monitoring of uncommon genotypes is needed.


Assuntos
Efeitos Psicossociais da Doença , Diarreia/epidemiologia , Infecções por Rotavirus/epidemiologia , Pré-Escolar , Genótipo , Humanos , Indonésia/epidemiologia , Lactente , Recém-Nascido , Rotavirus/classificação , Rotavirus/genética , Infecções por Rotavirus/virologia , Estações do Ano
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