Detalhe da pesquisa
1.
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Bioorg Med Chem Lett
; 27(1): 114-120, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816515
2.
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
J Biol Chem
; 290(33): 20360-73, 2015 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134571
3.
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Bioorg Med Chem Lett
; 26(17): 4362-6, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27491711
4.
Methyl-substitution of an iminohydantoin spiropiperidine ß-secretase (BACE-1) inhibitor has a profound effect on its potency.
Bioorg Med Chem Lett
; 25(21): 4812-4819, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195137
5.
Structural basis for selective small molecule kinase inhibition of activated c-Met.
J Biol Chem
; 286(13): 11218-25, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21247903
6.
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
J Biol Chem
; 286(8): 6433-48, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21118801
7.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 56(6): 3324-35, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22391531
8.
Discovery of pyrrolidine-based ß-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.
Bioorg Med Chem Lett
; 22(1): 240-4, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22130130
9.
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.
J Biol Chem
; 285(7): 4587-94, 2010 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19864428
10.
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
J Virol
; 84(15): 7625-33, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484498
11.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 54(11): 4812-24, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20805392
12.
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Bioorg Med Chem Lett
; 20(6): 1885-9, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20176482
13.
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Biochemistry
; 48(21): 4488-96, 2009 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19284778
14.
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
Bioorg Med Chem Lett
; 19(17): 4993-5, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19640712
15.
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
Bioorg Med Chem Lett
; 19(11): 2977-80, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19409780
16.
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 19(4): 1240-4, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155174
17.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455394
18.
Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
Protein Sci
; 16(12): 2626-35, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17965187
19.
Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.
J Med Chem
; 49(21): 6147-50, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034118
20.
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J Med Chem
; 49(25): 7270-3, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149856