RESUMO
Lupus erythematosus profundus (LEP), which is a variant of chronic cutaneous lupus erythematosus (CLE), is seen in approximately 2â¼3% of CLE patients, and only 10% to 20% of LEP patients present with systemic LE (SLE). LEP shows subcutaneous nodules with or without discoid LE (DLE). Linear LEP, a very rare variant of LEP, was first reported in 1991 in Japanese and in 1998 in English. Since LEP sometimes leaves skin depressions or scars as a result of atrophy of adipose tissue, early and adequate treatments are necessary. Here, we introduce an LEP case in which magnetic resonance imaging (MRI) was quite effective in evaluating a lesion that had been considered to be linear DLE.
Assuntos
Lúpus Eritematoso Discoide/patologia , Lúpus Eritematoso Sistêmico/patologia , Paniculite de Lúpus Eritematoso/patologia , Adulto , Anti-Inflamatórios/administração & dosagem , Anticorpos Antinucleares/análise , Biópsia , Feminino , Seguimentos , Humanos , Japão , Lúpus Eritematoso Discoide/tratamento farmacológico , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Imageamento por Ressonância Magnética/métodos , Paniculite de Lúpus Eritematoso/tratamento farmacológico , Paniculite de Lúpus Eritematoso/metabolismo , Prednisolona/administração & dosagemAssuntos
Paniculite/patologia , Febre Reumática/diagnóstico , Doença Aguda , Biópsia , Proteína C-Reativa/análise , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Paniculite/etiologia , Recidiva , Febre Reumática/complicações , Infecções Estreptocócicas/complicações , Streptococcus pyogenesAssuntos
Adenosina Trifosfatases/sangue , Anticorpos Antinucleares/sangue , Proteínas de Ligação a DNA/sangue , Dermatomiosite/imunologia , Adulto , Idoso , Braço/diagnóstico por imagem , Estudos de Coortes , Dermatomiosite/diagnóstico por imagem , Dermatomiosite/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto JovemAssuntos
Acrodermatite/imunologia , Derme/patologia , Imunoglobulina G/imunologia , Psoríase/imunologia , Acrodermatite/sangue , Acrodermatite/patologia , Idoso de 80 Anos ou mais , Biópsia , Derme/citologia , Derme/imunologia , Humanos , Imunoglobulina G/sangue , Imunoglobulina G/metabolismo , Linfócitos/imunologia , Linfócitos/metabolismo , Masculino , Plasmócitos/metabolismo , Plasmócitos/microbiologia , Psoríase/sangue , Psoríase/patologiaRESUMO
OBJECTIVE: A glycosylated transmembrane protein, CD147, has been implicated in regulating lymphocyte responsiveness and leukocyte recruitment. As lupus nephritis (LN) often follows a relapsing-remitting disease course, accurate understanding of the disease activity would be extremely helpful in improving prognosis. Unfortunately, neither clinical nor serological data can accurately reflect the histological features of LN. The present study investigated whether CD147 can accurately predict pathological features of LN. METHODS: Plasma and spot urine samples were collected from 64 patients who underwent renal biopsy between 2008 and 2011. Disease activity for LN tissues was evaluated using the biopsy activity index, and compared to levels of biomarkers including CD147. RESULTS: In LN tissues, CD147 induction was striking in injured glomeruli and infiltrating inflammatory cells, but not in damaged tubules representing atrophy. Plasma CD147 levels accurately reflected the histological disease activity. However, prediction using a single molecule would be quite difficult because of the complex pathogenesis of LN. The diagnostic accuracy of multiplex parameters indicated that the combination including plasma CD147 might yield excellent diagnostic abilities for guiding ideal LN therapy. CONCLUSION: Plasma CD147 levels might offer useful insights into disease activity as a crucial biomarker in patients with LN.