Evaluation of improvements in plan quality with Photon Optimizer v16.1 for single brain lesion SRS treatment.

Background: The purpose of this study is to compare the performance of the Photon Optimizer (PO) version 16.1 algorithm with its earlier version PO v13.6 and with Progressive Resolution Optimizer (PRO) version 13.6 algorithms. Materials and methods: 20 patients with single brain lesions treated with the stereotactic radiosurgery (SRS) technique were retrospectively selected for this study. Initially, for all patients volumetric modulated arc therapy (VMAT) SRS plans were generated with the PRO v 13.6 algorithm. Then, all the plans were re-generated with two versions 13.6 and 16.1 of PO algorithm using the same setup and dose-volume optimization objectives as that of PRO with a similar planning approach. The quality of the generated plans was analysed using ICRU 91 plan evaluation parameters and also using dice similarity co-efficient (DSC), centre of mass distance (CMD) between target and prescription isodose line, Monitor units (MU) and brain-gross tumor volume (GTV) 12 Gy volume. Paired Student t-test was used for statistical analysis with 0.05 as a significant value. Results: PO v16.1 improved all the dosimetric parameters studied compared to PO 13.6, the difference is statistically significant for all the parameters (p < 0.05), except for median dose and brain-GTV 12 Gy volume. PO v16.1 also showed statistically significant improvement for all the dosimetric parameters evaluated, except DSC and conformity index (CI), compared to PRO v13.6. Conclusion: The PO v16.1 generated plans are dosimetrically superior to PO v13.6 and PRO v13.6 in terms of target dose coverage and dose gradient with lesser beam modulation and plan complexity for single brain lesion SRS.

Study of dosimetric properties of flattened and unflattened megavoltage x ray beam on high Z implant materials.

PURPOSE: Addition of high Z implants in the treatment vicinity or beam path is unavoidable in certain clinical situation. In this work, we study the properties of radiation interaction parameters such as mass attenuation coefficient (MAC), x ray beam transmission factor (indirect beam attenuation), interface effects like backscatter dose perturbation factor (BSDF) and forward dose perturbation factor (FDPF) for flattened (FF) and unflattened (UF) x ray beams. METHODS: MAC for stainless steel and titanium alloy was measured using CC13 chamber with appropriate buildup in narrow beam geometry. The x ray beam transmission factors were measured for stainless steel and titanium alloy for different field size, off-axis, and depths. Profile analysis was performed using a radiation field analyzer (RFA) as a function of field size and depth to study the influence of phantom scattering and spectral variation in the beam. In addition, interface effects such as BSDF and FDPF were measured with gafchromic films at maximum BSDF peak position calculated using Acuros XB algorithm and with PPC40 chamber measured at exit side of high Z material, respectively. RESULTS: The MAC in both cases decreases with increase in energy for stainless steel (SS) and titanium (Ti) alloy. The MAC increases with the change in x ray beam type from flattened to UF beam because of relatively lower mean energy. The x ray beam transmission factor increases with the increase in energy, field size, and depth owing to increase in penetration power phantom scatter, respectively. The measured BSDF and FDPF were found to be in good agreement with AXB algorithm. CONCLUSION: The dosimetric properties of x ray photon beam were studied comprehensively in the presence of high Z material like stainless steel and titanium alloy using both flattened and UF beams to understand and incorporate the findings of various parameters in clinical condition due to the variation in energy spectrum from FF to UF x ray beam.

Removal of lead ions using OA-Fe3O4 magnetic nanoparticles-based pickering emulsion liquid membrane: process optimization using box-behnken response surface methodology.

The purpose of this study is to explore the pickering emulsion liquid membrane (PELM) performance for removing divalent lead ions (Pb II) from aqueous solution. In the present work, the membrane phase was prepared by dissolving methyltrioctylammonium chloride (Aliquat 336) with Mahua oil and adding oleic acid coated-ferrosoferric oxide (OA-Fe3O4) as magnetic nanoparticles. Experimental investigation on percentage removal of lead ions was carried out by studying the influencing process parameters such as pH, agitation speed, stripping concentration, initial feed concentration, surfactant concentration, treat ratio, M/S ratio and carrier concentration. The optimum condition to remove 98.52% of lead ions from the feed solutions has achieved at a stripping phase concentration of 0.3 M, treat ratio of 3, agitation speed of 300 rpm, initial feed concentration of 10 ppm and stabilizer concentration of 2 wt%. The experimental results were validated using box-behnken response surface methodology. The extraction ability of OA-Fe3O4 magnetic nanoparticles-based PELM has been evaluated using statistical optimization of all the affecting process factors using the design of the experiments.

Studies on Fundamental Interaction Parameters for Stainless Steel and Titanium Biomaterials Using Flattened and Un-Flattened Megavoltage X-Ray Beams.

Purpose: This work presents the measure of fundamental interaction parameters like mass attenuation coefficient (µ/ρ), mean energy, total atomic (σa) and electronic (σe) cross section, effective atomic number (Zeff), electron density (Nel) and mean free path (mfp) using FF and UF megavoltage x-ray beam for high Z implants. Methods: Narrow beam geometry is used to find out mass attenuation coefficient (µ/ρ) (MAC) which is then used to calculate mean energy (using NIST data), total atomic (σa) and electronic cross section (σe) for different energies. The effective atomic number (Zeff), Electron density (Nel), mean free path (mfp) for both flattened and unflattened x-ray beams for high Z material stainless steel (SS316) and titanium alloy (Grade 5) are studied. Results: The mean energies calculated from NIST data against mass attenuation coefficient were in good agreement with Monte Carlo value. It shows that spectral weighted effective atomic number is independent of megavoltage energies in the Compton region. Effective electron density calculated using Zeff and MAC method is lesser compared to direct method for both high Z materials. The mean free path (mfp) is higher along the central axis than off-axis for flattened beam in comparison to unflattened beam for both of the high Z materials studied because of the variation in energy spectrum for both FF and UF x-ray beams. Conclusion: This study elaborated the fundamental interaction parameters of different energies of flattened and unflattened x-ray beam interactions with high Z materials such as Stainless Steel (SS316) and Titanium (Grade5) relevant in a clinical scenario.

An Assessment of Dosimetric Characteristics of Inline 2.5 Mega Voltage Unflattened Imaging X-Ray Beam.

Purpose: The aim of this work is to study the dosimetric parameters of newly introduced 2.5 MV imaging x-ray beam used as inline imaging to do setup verification of the patient undergoing radiation therapy. As this x-ray beam is in megavoltage range but comprises of a lower energy spectrum. It is essential to study the pros and cons of 2.5 MV imaging x-ray beam for clinical use.Methods: The mean energy was calculated using the NIST XCOM table through MAC. Profile analysis was done using RFA to understand the percentage depth dose, degree of unflatteness, symmetry, penumbra and out of field dose. Dose to skin for the 2.5 MV x-ray beam was analysed for field sizes 10x10 cm2, 20x20 cm2, 30x30 cm2. Leakage measurements for treatment head and at the patient plane were done using IEC 819/98 protocol. Finally, the spatial resolution and contrast were analyzed with and without patient scatter medium. Results: The MAC at 15 cm off-axis was found to be lower than that at the CAX. Similarly, there was a decrease in mean energy from 0.47 MV to 0.37 MV at 15 cm off-axis. The reduction of mean energy towards off-axis is lower than the other high energy MV x-ray beams. The tuned absolute dose of 1 cGy/MU is consistent and within < ±1 %. The relative output factors were found to be in correlation with Co-60. The beam quality of 2.5 MV x-ray beam was found to be 0.4771. The profile parameters like the degree of unflatness of the 2.5 x-ray beam were studied at 85 %, 90 %, 95 % lateral distances, and the penumbra at different depth and field sizes are higher than the 6 MV treatment beam. In addition, out of field dose also drastically increases to a maximum of up to 30 % laterally at 5cm at deeper depths. The skin dose increases from 48.51 % to 88.15 % from 6 MV to 2.5 MV x-ray beam for the field size 10x10 cm2. Also, the skin dose increases from 88.15 % to 91.78 % from the field size 10x10 cm2 to 30x30 cm2. Although the measured leakage radiation for 2.5 MV x-ray beam at the patient plane and other than patient planes are with the tolerance limit, an increase in exposure towards gantry side compared to other areas around treatment head and the patient plane may lead to more skin dose to head and chest while imaging pelvis region. The MLC transmission of 2.5 MV x-ray beam such as inter, intra and edge effect are 0.40 %, 0.37 % and 11% respectively. The spatial resolution of 2.0, 1.25 and 0.9 LP/mm was observed for KV, 2.5MV, and 6 MV x-ray beams. The spatial resolution and contrast of 2.5 MV x-ray beam are superior to 6 MV x-ray beam and inferior to KV x-rays. Conclusions: The 2.5 MV x-ray imaging beam is analysed in view of beam characteristics and radiation safety to understand the above-studied concepts while using this imaging beam in a clinical situation. In future, if 2.5MV x-ray beam is used for treatment purpose with increased dose rate, the above-studied notions can be incorporated prior to implementation.