Detalhe da pesquisa
1.
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.
Pflugers Arch
; 2024 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38396259
2.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
J Biol Chem
; 298(4): 101787, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247391
3.
Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation.
J Biol Chem
; 298(3): 101721, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35151685
4.
Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.
J Biol Chem
; 298(8): 102222, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787374
5.
Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H α2ß2 tetramer.
J Biol Chem
; 298(12): 102614, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36265586
6.
Activation of the hypoxia response protects mice from amyloid-ß accumulation.
Cell Mol Life Sci
; 79(8): 432, 2022 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852609
7.
Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.
J Mol Cell Cardiol
; 164: 148-155, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34919895
8.
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
J Biol Chem
; 296: 100197, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33334883
9.
Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER.
J Biol Chem
; 296: 100453, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33631195
10.
PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis.
Angiogenesis
; 25(2): 259-274, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34997404
11.
Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice.
Arterioscler Thromb Vasc Biol
; 41(7): 2128-2140, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34039020
12.
The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.
J Biol Chem
; 295(50): 17158-17168, 2020 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33023907
13.
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.
Hum Mol Genet
; 28(19): 3309-3322, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31294445
14.
Prolyl and lysyl hydroxylases in collagen synthesis.
Exp Dermatol
; 30(1): 38-49, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32969070
15.
Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.
FASEB J
; 34(4): 5590-5609, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32100354
16.
A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.
Cell Mol Life Sci
; 77(18): 3627-3642, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31768607
17.
Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.
Int J Mol Sci
; 22(8)2021 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33919829
18.
BAMBI is a novel HIF1-dependent modulator of TGFß-mediated disruption of cell polarity during hypoxia.
J Cell Sci
; 131(10)2018 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29685894
19.
Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms.
J Biol Chem
; 293(20): 7645-7658, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29615493
20.
P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.
Hum Mol Genet
; 26(12): 2207-2217, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28419360