1.
J Med Chem
; 63(1): 157-162, 2020 01 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31804822
RESUMO
PROteolysis TArgeting Chimeras (PROTACs) targeting the degradation of MEK have been designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 was less effective with the PROTACs than a small-molecule inhibitor; the best PROTACs, however, were more effective in inhibiting proliferation of A375 cells than an inhibitor.