Detalhe da pesquisa
1.
Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Cell
; 181(3): 688-701.e16, 2020 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315618
2.
Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation.
Blood
; 141(9): 1047-1059, 2023 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455198
3.
Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules.
J Biol Chem
; 298(12): 102656, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36328247
4.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
PLoS Biol
; 18(12): e3000803, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275593
5.
Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers.
J Biol Chem
; 295(3): 757-770, 2020 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822503
6.
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.
Clin Sci (Lond)
; 135(13): 1545-1556, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192314
7.
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Clin Sci (Lond)
; 135(17): 2085-2097, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34402501
8.
Protein phosphatase 2A Aα regulates Aß protein expression and stability.
J Biol Chem
; 294(15): 5923-5934, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30796164
9.
Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45).
J Biol Chem
; 294(45): 17043-17059, 2019 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562245
10.
The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.
PLoS Biol
; 14(5): e1002467, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27213272
11.
The impact of phosphatases on proliferative and survival signaling in cancer.
Cell Mol Life Sci
; 75(15): 2695-2718, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29725697
12.
Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator.
Proteomics
; 17(22)2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28961369
13.
Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.
Proc Natl Acad Sci U S A
; 111(50): 17995-8000, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453078
14.
Bisphosphonates inactivate human EGFRs to exert antitumor actions.
Proc Natl Acad Sci U S A
; 111(50): 17989-94, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453081
15.
Food and science: Lessons learned from a great chef.
Am J Hematol
; 96(9): 1062-1063, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34264540
16.
Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
J Biol Chem
; 289(15): 10318-10329, 2014 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24385430
17.
Reengineered tricyclic anti-cancer agents.
Bioorg Med Chem
; 23(19): 6528-34, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372073
18.
Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice.
Transplantation
; 108(3): e36-e48, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38126420
19.
Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
Res Sq
; 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38585734
20.
Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis.
bioRxiv
; 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352401