Reduction in newborn screening metabolic false-positive results following a new collection protocol.

PURPOSE: Newborn screening includes testing for many metabolic diseases. False-positive results are higher among neonatal intensive care unit infants, resulting in increased confirmatory testing and family stress. Amino acid administration as a component of total parenteral nutrition is commonly used in the neonatal intensive care unit and suggested as a factor increasing false-positive results. The purpose of this study was to investigate the impact of a new sample collection protocol on false-positive results. METHODS: This was a 2-year retrospective cohort study. Infants were grouped by birth year into pre- and postprotocol implementation and stratified by birth weight category. In 2010, newborn screening samples were collected from all infants regardless of total parenteral nutrition administration. In 2011, the protocol was changed, and total parenteral nutrition was replaced with 10% dextrose in water (D10W) for 3 h before sample collection. RESULTS: Data from 539 neonatal intensive care unit admissions were reviewed. The new protocol reduced false-positive results for each birth weight group by at least 50% and overall by 74% (P = 0.008). The odds of having a false-positive result preintervention were 3.87 times higher than postintervention. The protocol reduced estimated costs by >80%. CONCLUSION: A protocol interrupting total parenteral nutrition for 3 h before newborn screening collection resulted in a 74% reduction in false-positive results in a neonatal intensive care unit.

Nosocomial infection in neonates: inevitable or preventable?

In the neonatal intensive care unit population the nosocomial infection rate is highest in the lowest-birth-weight infants. It is this group of infants who require the most therapeutic interventions to support them leading to frequent invasive procedures and the longest exposure to the hospital environment. However, infection rates vary from one unit to another, suggesting that there are differences in either how infection rates are determined or the care provided in the various units. This article will describe nosocomial infections and rates in the neonatal intensive care unit and identify strategies of care to minimize the risks of nosocomial infection in low-birth-weight infants.