Detalhe da pesquisa
1.
Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes.
Int J Mol Sci
; 18(8)2017 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28767098
2.
Potential Diagnostic and Therapeutic Applications of Oligonucleotide Aptamers in Breast Cancer.
Int J Mol Sci
; 18(9)2017 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28841163
3.
Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential.
Mol Ther Nucleic Acids
; 35(1): 102146, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38444701
4.
A bimolecular modification strategy for developing long-lasting bone anabolic aptamer.
Mol Ther Nucleic Acids
; 34: 102073, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38074899
5.
Drug discovery of sclerostin inhibitors.
Acta Pharm Sin B
; 12(5): 2150-2170, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35646527
6.
Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation.
Nat Commun
; 13(1): 4241, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35869074
7.
Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice.
Theranostics
; 12(13): 5645-5674, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35966595
8.
Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy.
Front Cell Dev Biol
; 9: 626910, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33855017
9.
Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications.
ACS Appl Mater Interfaces
; 13(8): 9500-9519, 2021 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32603135
10.
The application of an aryl hydrazine linker prevents beta-elimination side products in the SPPS of C-terminal cysteine peptides.
J Pept Sci
; 16(6): 309-13, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20474043
11.
A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice.
Adv Sci (Weinh)
; 7(13): 1903451, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32670749
12.
Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7-36) amide.
Bioorg Med Chem
; 16(16): 7607-14, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18656368
13.
Stability and bioactivity studies on dipeptidyl peptidase IV resistant glucogan-like peptide-1 analogues.
Protein Pept Lett
; 19(2): 203-11, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21838700
14.
Synthesis and bioactivity evaluation of dipeptidyl peptidase IV resistant glucagon-like peptide-1 analogues.
Protein Pept Lett
; 17(10): 1290-5, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594158