Detalhe da pesquisa
1.
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.
Brain Behav Immun
; 120: 121-140, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38777288
2.
New insights into P2X7 receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain.
J Biol Chem
; 298(10): 102495, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36115462
3.
Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice.
Epilepsia
; 64(2): 511-523, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36507708
4.
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails.
Mar Drugs
; 21(6)2023 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37367681
5.
Animal Models for the Investigation of P2X7 Receptors.
Int J Mol Sci
; 24(9)2023 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37175933
6.
Functional P2X7 Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia.
J Neurosci
; 41(12): 2615-2629, 2021 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33563723
7.
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions.
J Neuroinflammation
; 19(1): 256, 2022 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36224611
8.
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.
Arch Toxicol
; 95(12): 3695-3716, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34628512
9.
Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel α-Conotoxin with an Extended N-Terminal Tail.
Mar Drugs
; 19(3)2021 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33801301
10.
Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc Natl Acad Sci U S A
; 114(38): E8100-E8109, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874590
11.
Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.
Proc Natl Acad Sci U S A
; 109(28): 11396-401, 2012 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22745172
12.
Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels.
ACS Pharmacol Transl Sci
; 7(3): 771-786, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38495220
13.
Validation of Alexa-647-ATP as a powerful tool to study P2X receptor ligand binding and desensitization.
Biochem Biophys Res Commun
; 438(2): 295-300, 2013 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23896604
14.
Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain.
Elife
; 122023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598131
15.
P2X7 receptor inhibition ameliorates ubiquitin-proteasome system dysfunction associated with Alzheimer's disease.
Alzheimers Res Ther
; 15(1): 105, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37287063
16.
The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice.
Br J Pharmacol
; 180(13): 1710-1729, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36637008
17.
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis.
Mucosal Immunol
; 16(2): 180-193, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634819
18.
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3ß2 and α3ß4 Nicotinic Receptors via an Electrostatic Mechanism.
ACS Chem Neurosci
; 14(24): 4311-4322, 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051211
19.
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
Br J Pharmacol
; 180 Suppl 2: S145-S222, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123150
20.
Efficient binding of 4/7 α-conotoxins to nicotinic α4ß2 receptors is prevented by Arg185 and Pro195 in the α4 subunit.
Mol Pharmacol
; 82(4): 711-8, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22802270