Detalhe da pesquisa
1.
Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Bioorg Med Chem Lett
; 100: 129630, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38307441
2.
Suppression of inflammation by a synthetic histone mimic.
Nature
; 468(7327): 1119-23, 2010 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21068722
3.
Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists.
Bioorg Med Chem Lett
; 24(4): 1098-103, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24462665
4.
From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Bioorg Med Chem Lett
; 22(8): 2963-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22386529
5.
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Bioorg Med Chem Lett
; 22(8): 2968-72, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437115
6.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744298
7.
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
J Med Chem
; 50(4): 685-95, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17243659
8.
Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.
J Invest Dermatol
; 137(10): 2110-2119, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28595996
9.
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.
PLoS One
; 11(2): e0147979, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26870941
10.
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.
ACS Med Chem Lett
; 7(4): 379-84, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096045
11.
Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription.
Mol Endocrinol
; 18(10): 2378-87, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15218078
12.
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.
Cell Rep
; 11(9): 1446-57, 2015 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26004183
13.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26090771
14.
Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice.
Physiol Genomics
; 9(2): 93-102, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12006675
15.
Naphthyridines as novel BET family bromodomain inhibitors.
ChemMedChem
; 9(3): 580-9, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24000170
16.
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
J Med Chem
; 57(19): 8111-31, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25249180
17.
Discovery of Pyridones As Oral AMPK Direct Activators.
ACS Med Chem Lett
; 4(7): 632-6, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900722
18.
Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.
J Med Chem
; 56(19): 7501-15, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24015967
19.
Discovery and characterization of small molecule inhibitors of the BET family bromodomains.
J Med Chem
; 54(11): 3827-38, 2011 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568322
20.
Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.
Genome Res
; 13(7): 1654-64, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12805272