Detalhe da pesquisa
1.
Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells.
J Immunol
; 212(6): 933-940, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38275935
2.
Synthesis of Deuterated Endochin-Like Quinolones.
J Labelled Comp Radiopharm
; 67(5): 186-196, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38661253
3.
Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo.
J Infect Dis
; 226(7): 1267-1275, 2022 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512141
4.
Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection.
Antimicrob Agents Chemother
; 65(9): e0066221, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34152821
5.
Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094134
6.
Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32540978
7.
Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems.
Pharm Dev Technol
; 25(5): 625-639, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32031478
8.
Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway.
J Virol
; 92(6)2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29263267
9.
ELQ-331 as a prototype for extremely durable chemoprotection against malaria.
Malar J
; 18(1): 291, 2019 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455339
10.
Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27919897
11.
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.
PLoS Pathog
; 11(12): e1005324, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26646986
12.
Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.
Antimicrob Agents Chemother
; 60(8): 4972-82, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27297476
13.
Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.
Antimicrob Agents Chemother
; 60(8): 4853-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27270285
14.
Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.
Antimicrob Agents Chemother
; 59(4): 1977-82, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605352
15.
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Antimicrob Agents Chemother
; 59(9): 5555-60, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124159
16.
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
Proc Natl Acad Sci U S A
; 109(39): 15936-41, 2012 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23019377
17.
Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis.
ACS Infect Dis
; 10(4): 1405-1413, 2024 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38563132
18.
Long-acting intramuscular injections of ELQ-331, an antimalarial agent.
Eur J Pharm Sci
; 198: 106795, 2024 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38729224
19.
3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.
ACS Infect Dis
; 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38862127
20.
Divergent metabolic programmes control two populations of MAIT cells that protect the lung.
Nat Cell Biol
; 25(6): 877-891, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37231163