Pesquisa | BVS IEC

1.

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and ß-YAC transgenic mice.

Oseghale, Aluya R; Zhu, Xingguo; Li, Biaoru; Peterson, Kenneth R; Nudelman, Abraham; Rephaeli, Ada; Xu, Hongyan; Pace, Betty S.

Blood Cells Mol Dis ; 79: 102345, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31351219

2.

Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors.

Tarasenko, Nataly; Chekroun-Setti, Hanna; Nudelman, Abraham; Rephaeli, Ada.

J Cell Biochem ; 119(4): 3417-3428, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29135083

3.

AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.

Moyal, Lilach; Goldfeiz, Neta; Gorovitz, Batia; Rephaeli, Ada; Tal, Efrat; Tarasenko, Nataly; Nudelman, Abraham; Ziv, Yael; Hodak, Emmilia.

Invest New Drugs ; 36(1): 1-9, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-28884410

4.

Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft.

Tarasenko, Nataly; Nudelman, Abraham; Rozic, Gabriela; Cutts, Suzanne M; Rephaeli, Ada.

Invest New Drugs ; 35(4): 412-426, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28315153

5.

Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.

Furman, Svetlana; Nissim-Bardugo, Elinor; Zeeli, Shani; Weitman, Michal; Nudelman, Abraham; Finkin-Groner, Efrat; Moradov, Dorit; Shifrin, Helena; Schorer-Apelbaum, Donna; Weinstock, Marta.

Bioorg Med Chem Lett ; 24(10): 2283-7, 2014 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-24731278

6.

Mutual Prodrugs - Codrugs.

Nudelman, Abraham.

Curr Med Chem ; 30(38): 4283-4339, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-36503392

7.

Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.

Berkovitch-Luria, Gili; Weitman, Michal; Nudelman, Abraham; Rephaeli, Ada; Malik, Zvi.

Invest New Drugs ; 30(3): 1028-38, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21509470

8.

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.

Tarasenko, Nataly; Kessler-Icekson, Gania; Boer, Pnina; Inbal, Aida; Schlesinger, Hadassa; Phillips, Don R; Cutts, Suzanne M; Nudelman, Abraham; Rephaeli, Ada.

Invest New Drugs ; 30(1): 130-43, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20862515

9.

Dimeric Drugs.

Nudelman, Abraham.

Curr Med Chem ; 29(16): 2751-2845, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-34375175

10.

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells.

Mansour, Oula C; Nudelman, Abraham; Rephaeli, Ada; Phillips, Don R; Cutts, Suzanne M; Evison, Benny J.

Cancer Chemother Pharmacol ; 89(6): 773-784, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35460360

11.

Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote.

Weitman, Michal; Eisenkraft, Arik; TaShma, Zeev; Makarovsky, Igor; Last, David; Daniels, Dianne; Guez, David; Shneor, Ran; Mardor, Yael; Nudelman, Abraham; Krivoy, Amir.

Sci Rep ; 12(1): 18078, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-36302937

12.

Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.

Feuerstein, Tamar; Berkovitch-Luria, Gili; Nudelman, Abraham; Rephaeli, Ada; Malik, Zvi.

Photochem Photobiol Sci ; 10(12): 1926-33, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-22020364

13.

Valproic Acid Prodrug Affects Selective Markers, Augments Doxorubicin Anticancer Activity and Attenuates Its Toxicity in a Murine Model of Aggressive Breast Cancer.

Tarasenko, Nataly; Wilner, Harel Josef; Nudelman, Abraham; Kessler-Icekson, Gania; Rephaeli, Ada.

Pharmaceuticals (Basel) ; 14(12)2021 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-34959644

14.

Comparison of the tissue distribution and metabolism of AN1284, a potent anti-inflammatory agent, after subcutaneous and oral administration in mice.

Weitman, Michal; Bejar, Corina; Melamed, Michal; Weill, Tehilla; Yanovsky, Inessa; Zeeli, Shani; Nudelman, Abraham; Weinstock, Marta.

Naunyn Schmiedebergs Arch Pharmacol ; 394(10): 2077-2089, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34309687

15.

A switch in mechanism of action prevents doxorubicin-mediated cardiac damage.

Cheong, Alison; McGrath, Sean; Robinson, Tina; Maliki, Ruqaya; Spurling, Alex; Lock, Peter; Rephaeli, Ada; Nudelman, Abraham; Parker, Belinda S; Pepe, Salvatore; Cutts, Suzanne M.

Biochem Pharmacol ; 185: 114410, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33428897

16.

Cardioprotection by AN-7, a prodrug of the histone deacetylase inhibitor butyric acid: Selective activity in hypoxic cardiomyocytes and cardiofibroblasts.

Nudelman, Vadim; Zahalka, Muayad A; Nudelman, Abraham; Rephaeli, Ada; Kessler-Icekson, Gania.

Eur J Pharmacol ; 882: 173255, 2020 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-32553737

17.

Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy.

Ugarenko, Michal; Chan, Chee-Kai; Nudelman, Abraham; Rephaeli, Ada; Cutts, Suzanne M; Phillips, Don R.

Oncol Res ; 17(7): 283-99, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19408574

18.

Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex).

Tarasenko, Nataly; Nudelman, Abraham; Tarasenko, Igor; Entin-Meer, Michal; Hass-Kogan, Daphne; Inbal, Aida; Rephaeli, Ada.

Clin Exp Metastasis ; 25(7): 703-16, 2008.

Artigo em Inglês | MEDLINE | ID: mdl-18506586

19.

Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.

Engel, Dikla; Nudelman, Abraham; Tarasenko, Nataly; Levovich, Inesa; Makarovsky, Igor; Sochotnikov, Segev; Tarasenko, Igor; Rephaeli, Ada.

J Med Chem ; 51(2): 314-23, 2008 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-18163551

20.

A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects.

Nudelman, Abraham; Gil-Ad, Irit; Shpaisman, Nava; Terasenko, Igor; Ron, Hanna; Savitsky, Kinneret; Geffen, Yona; Weizman, Abraham; Rephaeli, Ada.

J Med Chem ; 51(9): 2858-62, 2008 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-18363346

BVS IEC

Instituto Evandro Chagas

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