Facilitators and barriers to attending postpartum screening in women with a recent pregnancy complicated by gestational diabetes mellitus: a qualitative study.

OBJECTIVE: Pregnant women with gestational diabetes mellitus (GDM) are 50% more likely to develop type II diabetes (T2D) within 6 months to 2 years after giving birth. Therefore, international guidelines recommend it is best practice for women diagnosed with GDM to attend screening for T2D 6-12 weeks postpartum and every 1-3 years thereafter for life. However, uptake of postpartum screening is suboptimal. This study will explore the facilitators of and barriers to attending postpartum screening for T2D that women experience. STUDY DESIGN: This was a prospective qualitative cohort study using thematic analysis. METHODS: A total of 27 in-depth, semistructured interviews were conducted over the telephone with women who had recent GDM. Interviews were recorded and transcribed, and data were analysed using thematic analysis. RESULTS: Facilitators of and barriers to attending postpartum screening were identified at three different levels: personal, intervention, and healthcare systems level. The most common facilitators identified were concern for their own health and having the importance of screening explained to them by a health professional. The most common barriers identified were confusion over the test and COVID-19. CONCLUSION: This study identified several facilitators of and barriers to attending postpartum screening. These findings will help to inform research and interventions for improving rates of attendance at postpartum screening to reduce the subsequent risk of developing T2D.

Hand hygiene compliance by direct observation in physicians and nurses: a systematic review and meta-analysis.

BACKGROUND: Direct observation of hand hygiene compliance is the gold standard despite limitations and potential for bias. Previous literature highlights poorer hand hygiene compliance among physicians than nurses and suggests that covert monitoring may give better compliance estimates than overt monitoring. AIM: To explore differences in compliance between physicians and nurses further, and to determine whether compliance estimates differed when observations were covert rather than overt. METHODS: A systematic search of databases PubMed, Embase, CENTRAL and CINAHL was performed. Experimental or observational studies in hospital settings in high-income countries published in English from 2010 onwards were included if estimates for both physicians and nurses using direct observation were reported. The search yielded 4814 studies, of which 105 were included. FINDINGS: The weighted pooled compliance rate for nurses was 52% (95% CI: 47-57) and for doctors was 45% (95% CI: 40-49%). Heterogeneity was considerable (I2 = 99%). The majority of studies were at moderate or high risk of bias. Random-effects meta-analysis of low risk of bias studies suggests higher compliance for nurses than physicians for both overt (difference of 7%; 95% CI for the difference: 0.8-13.5; P = 0.027) and covert (difference of 7%; 95% CI: 3-11; P = 0.0002) observation. Considerable heterogeneity was found in all analyses. CONCLUSION: Wide variability in compliance estimates and differences in the methodological quality of hand hygiene studies were identified. Further research with meta-regression should explore sources of heterogeneity and improve the conduct and reporting of hand hygiene studies.

Multi-center planning study of radiosurgery for intracranial metastases through Automation (MC-PRIMA) by crowdsourcing prior web-based plan challenge study.

BACKGROUND: Planning radiosurgery to multiple intracranial metastases is complex and shows large variability in dosimetric quality among planners and treatment planning systems (TPS). This project aimed to determine whether autoplanning using the Muliple Brain Mets (AutoMBM) software can improve plan quality and reduce inter-planner variability by crowdsourcing results from prior international planning study. METHODS: Twenty-four institutions autoplanned with AutoMBM on a five metastases case from a prior international planning competition from which population statistics (means and variances) of 23 dosimetric metrics and resulting composite plan score (maximum score = 150) of other TPS (Eclipse, Monaco, RayStation, iPlan, GammaPlan, MultiPlan) were crowdsourced. Plan results of AutoMBM and each of the other TPS were compared using two sample t-tests for means and Levene's tests for variances. Plan quality of AutoMBM was correlated with the planner' experience and compared between academic and non-academic centers. RESULTS: AutoMBM produced plans with comparable composite plan score to GammaPlan, MultiPlan, Eclipse and iPlan (127.6 vs. 131.7 vs. 127.3 vs. 127.3 and 126.7; all p > 0.05) and superior to Monaco and RayStation (118.3 and 108.6; both p < 0.05). Inter-planner variability of overall plan quality was lowest for AutoMBM among all TPS (all p < 0.05). AutoMBM's plan quality did not differ between academic and non-academic centers and uncorrelated with planning experience (all p > 0.05). CONCLUSIONS: By plan crowdsourcing prior international plan challenge, AutoMBM produces high and consistent plan quality independent of the planning experience and the institution that is crucial to addressing the technical bottleneck of SRS to intracranial metastases.

Medical engineering at Cardiff University. Part 1: Undergraduate programmes of study.

Cardiff University has offered a medical engineering undergraduate programme since 2001 and hence delivers one of the longest-running and most established medical engineering programmes within the UK. It currently offers BEng (Hons) and MEng (Hons) programmes that are both accredited by the Institution of Mechanical Engineers and include the option to undertake a year in industrial employment. The admissions policy ensures that the intake consists of a diverse range of students and is typically very successful in attracting female students. The programmes consist of six key academic threads which ensure that the content is both relevant and continuous, with all threads tailored to provide a patient-focused learning environment. Students initially learn core and fundamental principles in years 1 and 2, supported by a range of laboratories and practical experimentation. The latter years then encourage the students to corroborate and apply this knowledge, including involvement in a range of project-based learning exercises. The programme is delivered by a core of experienced academic medical engineers, with support from other engineering colleagues, as well as colleagues from the School of Biosciences, the School of Medicine, and the National Health Service. Thus, the programme delivers a wide range of modules which guarantee that graduating students have a thorough understanding of all possible career options. These two factors are significant in making it possible for students to follow their chosen career path upon graduation.

Medical engineering at Cardiff University. Part 2: Postgraduate programmes of study.

The Medical Engineering team within the School of Engineering, Cardiff University, delivers two postgraduate programmes of study. Established over 10 years ago, the part-time MSc programmes in Orthopaedic Engineering and Clinical Engineering offer the opportunity of further study while remaining within full-time employment. Both programmes deliver 120 taught credits over two academic years via a series of residential weekends, with successful completion enabling the student to undertake and then defend a 60-credit research dissertation. Fulfilling a specific role on the career pathway for both student cohorts, the strength of each programme is indicated by the consistent number of applicants.

The effect of preparation height and taper on cement lute stress: a three-dimensional finite element analysis.

Three dimensional finite element models of an upper second premolar and molar with full veneer gold crown preparations were developed from extracted samples. The cement lute width was kept constant at 40 microm, but the height and preparation taper were varied. For both models the preparation height was either 1.5 mm (short preparation) or 3 mm (long preparation). The preparation taper was either 10 degree or 30 degree, giving a total of eight models. Each model was loaded with a 10 N horizontal load, a 10 N vertical load or a 10 N load distributed across the occlusal surface. The maximum shear stress and the maximum Von Mises' stress in the cement lute of each model were recorded. For the premolar, the maximum shear stresses ranged from 0.3-5.43 MPa and the maximum Von Mises' stress ranged from 1.44-14.98 MPa. For the molar, the maximum shear stresses ranged from 0.15-5.22 MPa and the maximum Von Mises' stress ranged from 0.3 7-15.02 MPa. The stress fields were consistently higher in the premolar with a 30 degree preparation taper compared to the 10 degree taper. The attainment of a cavity taper of 100 is still important to minimise stress in the cement lute and is particularly important in teeth with a lower preparation surface area such as a premolar

The effects of intravenous alendronate in Paget's disease of bone.

We studied the effects of intravenous alendronate on disease activity in 36 patients with active Paget's disease of bone. Alendronate was administered to 3 groups of 12 patients at doses of 2.5, 5, and 10 mg intravenously daily for 5 consecutive days. The patients were matched for disease activity. Symptomatic improvement was seen in at least 10 patients in each treatment group. Alendronate induced a dose-dependent suppression of biochemical indices of bone turnover in all patients. A significant reduction in the mean fasting urinary excretion of hydroxyproline occurred within 2 days of starting treatment, reaching a nadir at 2-4 weeks, which was most marked in patients receiving 10 mg of alendronate (p < 0.05). There was a slower fall in serum alkaline phosphatase activity with maximal suppression occurring 3 months after the start of treatment. The degree of suppression was least for those receiving 2.5 mg of alendronate (p < 0.05) but no difference in response was observed for the other dosages. The duration of response was also dose-related. A significant fall in the serum calcium and urinary excretion of calcium occurred from the second day of treatment but returned to pretreatment values by 4 months. A transient fall in the mean lymphocyte count was observed, which was similar for each group. This was associated with a short-lived fever in 3 patients receiving 10 mg, in 4 patients receiving 5 mg, and in 2 patients receiving 2.5 mg.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of five daily 1 h infusions of alendronate in Paget's disease of bone.

We report a randomized placebo-controlled double-blind study of amino-hydroxybutylidene bisphosphonate (alendronate), infused over 1 h, in 15 patients with Paget's disease of bone. Alendronate, 10 mg/day for 5 days, suppressed urinary hydroxyproline to 44.9 +/- 4.8% and serum alkaline phosphatase to 74.6 +/- 5.4% of their pretreatment values within 1 month of the start of treatment. Within 5 months of the start of treatment serum alkaline phosphatase fell to 47.9 +/- 6.3% of pretreatment values. These effects were associated with a decrease in serum calcium and phosphate and in urinary calcium excretion and with a rise in serum iPTH values. A transient fever was observed in 3 of 10 patients who received alendronate during the course of the infusions, and this was associated with a decrease in the total and differential white cell count. No adverse effects were noted on renal function as judged by glomerular filtration rate and indices of proximal and distal tubular function. This regimen may simplify the management of patients with Paget's disease of bone.

Treatment of Paget's disease of bone with aminohydroxybutylidene bisphosphonate.

This study examined the effects of aminohydroxybutylidene bisphosphonate in 30 patients with Paget's disease of bone, administered as an intravenous infusion for 5 consecutive days. Treatment (5 mg IV daily) induced marked suppression of biochemical indices of disease activity. Urinary excretion of hydroxyproline fell to 50% of pretreatment values within 2 weeks and was followed by a similar, but later, decline in the serum activity of alkaline phosphatase. Disease activity remained suppressed throughout the 6 months of observation, and only 1 patients showed biochemical signs of an early relapse. Symptomatic improvement was noted in 27 of the 30 patients. Bone biopsies, undertaken in 10 patients, indicated no adverse effects on mineralization. Transient falls were noted in the total white cell count, particularly the lymphocyte and neutrophil fractions, and were associated with short-lived fever in 3 patients. We conclude that short courses of intravenous AHButBP provide a promising treatment for active Paget's disease of bone.

Computed tomographic patterns of muscles in neuromuscular diseases.

Computed tomographic (CT) scans of muscle in 35 patients with neuromuscular diseases showed distinct patterns in nerve and muscle diseases. Neural diseases first showed as muscle atrophy, with decreased density in the muscles occurring later in the course of disease. Primary muscle diseases showed early decreased density in the muscles, with atrophy occurring later. The CT scan allows objective assessment of muscle mass and may be used to help select muscles for biopsy.

Primary position vertical nystagmus and cerebellar ataxia.

Hereditary cerebellar ataxia was evaluated clinically and by electro-oculography in three members of a family. There was no clinical evidence of exttra-cerebellar dysfunction although quantitative eye movement analysis did shown internuclear ophthalmoparesis and slow saccadic velocity suggestive of brainstem dysfunction. In addition, oculomotor examination showed primary position vertical nystagmus in all patients. Other findings were in accord with previous reports of cerebellar-related oculomotor dysfunction.

National need for neurologists: commentary on the GMENAC report: (Graduate Medical Education National Advisory Committee).

In an incomplete study, the Government Medical Education National Advisory Committee in 1980 suggested that there would be an oversupply of neurologists by 1990. A subsequent Advisory Committee undertook an in-depth evaluation, concluding that neurology would be in near balance by 1990. Several factors that were not used by the Advisory Committee could alter these conclusions, depending on the weight given to these factors separately or collectively. We do not have enough evidence to justify any action now to control the growth of neurology.

The pharmacokinetics of pyridostigmine.

A simplified gas chromatographic method for measuring quaternary ammonium compounds has been developed and used to measure the serum concentration of pyridostigmine in human beings. Pyridostigmine is present in the serum within 1 hour after oral administration and reaches a peak at 2 hours. Results in several patients suggest that the serum concentration achieved is related to the size of the dose and that there is a relationship between serum concentration and clinical response.

Effects of amino-butylidene diphosphonate in hypercalcemia due to malignancy.

We studied the effect of a single 5 mg intravenous infusion of amino-butylidene diphosphonate (ABDP) in nine patients with hypercalcemia of malignancy, in whom serum calcium values were stable or rising after intravascular volume expansion. Serum calcium fell progressively in all patients and in seven reached the normal reference range by day 6 (p less than 0.001). The decrease in serum calcium was associated with a decrease in the fasting urinary calcium/creatinine ratio (p less than 0.05). Hypercalcemia recurred in seven of the patients by day 12, but two patients remained normocalcemic for 21 days. We conclude that ABDP is a highly potent diphosphonate and that a single intravenous infusion is capable of inhibiting tumour-mediated bone resorption for several days.

The influence of the restoration-tooth interface in light cured composite restorations: a finite element analysis.

This study examines the early shrinkage behaviour of dental composite resins, and in particular the interfacial stresses around the margins of a composite restoration. The development of stresses at the restoration-tooth interface can have a detrimental effect on the longevity of a restoration. The influence of this interface on the stress system generated in the tooth was examined using finite element analysis. The restoration-tooth interface was simulated using spring elements of varying spring constants (k = 1, 10(2), 10(4), 10(10) N/mm). Interfacial stresses varied from -0.15 to 0.42 MPa for a spring constant of 1 N/mm, and from -19 to 68 MPa for a spring constant of 10(10) N/mm. Correlations between stiffness at the restoration-tooth interface and higher shrinkage stresses due to restricted shrinkage were found. Interfacial failure at the upper and lower regions of the interface, as well as cuspal movements of the order of 2 microm were predicated for the model of the highest spring constant, 10(10) N/mm. The restoration-tooth interface modelled by the spring elements was seen to have a conclusive effect on the ensuing stress system, as well as the longevity of the restoration.

Stress protection due to external fixation.

Bone is sensitive to mechanical influences. The presence of an orthopaedic device will impose constraints on the mechanical environment that may influence subsequent remodelling and repair. An Oxford External Fixator was applied to six intact ovine tibiae. The strains engendered during normal walking were then recorded from strain gauges applied to the mid-shaft of the bone. The fixator configuration was then altered such that the intact fixator bar connecting the pins was replaced with a sectioned version that did not permit load transfer through the fixator, and the strain environment re-recorded. The peak strains recorded with the intact bar were significantly lower than those recorded with the sectioned bar. This showed that the use of a fixator with an intact bar resulted in significant stress protection of the underlying bone. A fixator was then applied to both the right and left tibiae of a further six animals and the resulting strain environment and corresponding remodelling response was observed over 16 weeks. In each case one fixator was configured with an intact bar (the stress protected limb), whilst the other utilised a sectioned bar (the unprotected limb). The results showed that over this period the bone mineral content fell by 9% in the stress protected limb compared to the unprotected limp. Quantitative assessment of the bones showed that this bone loss occurred as a direct consequence of resorption on the periosteal and endosteal surfaces. In addition, strain recordings at week 16 showed that the fixator was still stress protecting the tibia.