Co-precipitation of Ni, Cr, Mn, Pb and Zn in industrial wastewater and sediment samples with copper(II) cyclo-hexylmethyldithiocarbamate for their flame atomic absorption spectrometric determination.

A co-precipitation technique for nickel(II), chromium(II), manganese(II), lead(II) and zinc(II) with the aid of copper(II) cyclo-hexylmethyldithiocarbamate was established. The influences of some analytical parameters such as pH, sample volume, amounts of cyclo-hexylmethyldithiocarbamate and copper(II) on the recovery of metal ions were investigated. The heavy metals in the precipitate were determined by flame atomic absorption spectrophotometry. The range of detection limits for the heavy metals was 0.003-0.005 mg/L. The atomic spectrometric technique with co-precipitation procedure was successfully applied for the determination of Ni, Cr, Mn, Pb and Zn in industrial wastewater and sediment samples from Ladipo stream in Lagos, Nigeria. The mean concentrations for these metals using co-precipitation procedure were not significantly different from corresponding concentrations obtained using spectrometric techniques without co-precipitation procedure.

Evaluation of the antioxidative potential of diisopropyldithiocarbamates sodium salt on diclofenac-induced toxicity in male albino rats.

Diclofenac (DIC) is a non-steroidal anti-inflammatory drug (NSAID) which is known to induce oxidative stress. Dithiocarbamates are compounds with proven antioxidant effect. The aim of the present study was to investigate the antioxidant capacity of diisopropyldithiocarbamates sodium salt (a synthetized compound) (Na(i-Pr2dtc)) against diclofenac-induced toxicity in the testes of male Wistar albino rats. The animals were assigned into six groups of six rats each. Group 1 (control) received corn oil, Groups 2, 3, 4, 5, 6 received DIC (100 mg/kg), DIC and (Na(i-Pr2dtc) (30 mg/kg), DIC and vitamin E (30 mg/kg), (Na(i-Pr2dtc) (30 mg/kg) and vitamin E only respectively. Our findings show that treatment with DIC significantly reduced superoxide dismutase (SOD) activity by 42% compared to normal control (NC) animals. In DIC treated group, Na(i-Pr2dtc) caused a 17% elevation of catalase (CAT) activity compared to DIC only group. Reduced glutathione level was significantly reduced in DIC only treated group when compared with DIC and VIT E treated group. Photomicrographs of testis from Na(i-Pr2dtc) treated rats showed normal seminiferous epithelium with no lesions. In conclusion, Na(i-Pr2dtc) has antioxidant properties.