Detalhe da pesquisa
1.
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Bioorg Med Chem Lett
; 29(4): 560-562, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30616904
2.
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.
Bioorg Med Chem Lett
; 27(20): 4755-4759, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927796
3.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem J
; 473(13): 1869-79, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27099339
4.
A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.
Anal Biochem
; 503: 58-64, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27036617
5.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27086121
6.
A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1.
Anal Biochem
; 440(1): 1-5, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23688965
7.
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
Sci Rep
; 10(1): 3836, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123273
8.
Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.
Br J Haematol
; 166(1): 145-8, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24606602
9.
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy.
Clin Cancer Res
; 14(10): 3124-31, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483380
10.
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.
Cancer Cell
; 35(3): 519-533.e8, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30889383
11.
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 18(3): 959-62, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182285
12.
Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Bioorg Med Chem Lett
; 18(6): 1799-803, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313293
13.
A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.
Bioorg Med Chem Lett
; 18(2): 674-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061446
14.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403352
15.
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Cancer Cell
; 33(6): 1078-1093.e12, 2018 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894693
16.
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.
Cancer Res
; 65(10): 4389-400, 2005 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15899831
17.
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.
Cancer Res
; 62(16): 4645-55, 2002 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12183421
18.
IncucyteDRC: An R package for the dose response analysis of live cell imaging data.
F1000Res
; 5: 962, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27703665
19.
An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.
F1000Res
; 5: 736, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27610220
20.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
F1000Res
; 5: 1005, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429741