Detalhe da pesquisa
1.
Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors.
Bioorg Med Chem Lett
; 98: 129588, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086467
2.
Isoform-Selective Fluorescent Labeling of 14-3-3σ by Acrylamide-Containing Fusicoccins.
Chemistry
; 29(41): e202301059, 2023 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37170712
3.
Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY.
Protein Expr Purif
; 195-196: 106089, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35307559
4.
Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3-phospholigand interactions.
Bioorg Med Chem
; 73: 117020, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36182801
5.
Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B.
Bioorg Med Chem Lett
; 48: 128265, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34273487
6.
Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets.
Molecules
; 26(8)2021 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33917117
7.
Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine.
Bioconjug Chem
; 30(2): 454-460, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30428256
8.
A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.
Chemistry
; 25(59): 13531-13536, 2019 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31393030
9.
Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity.
Chemistry
; 24(60): 16066-16071, 2018 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30238524
10.
Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.
J Am Chem Soc
; 137(50): 15624-7, 2015 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26632868
11.
RNA-directed amino acid coupling as a model reaction for primitive coded translation.
Chembiochem
; 15(6): 794-8, 2014 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24591237
12.
Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.
Chem Rec
; 13(6): 561-75, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24307545
13.
Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.
Bioorg Med Chem
; 21(14): 4004-10, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23107667
14.
Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.
Bioorg Med Chem Lett
; 22(6): 2354-8, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22385827
15.
Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.
Angew Chem Int Ed Engl
; 51(2): 509-12, 2012 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105970
16.
Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases.
J Am Chem Soc
; 133(4): 958-63, 2011 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21158442
17.
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors.
Chem Commun (Camb)
; 56(76): 11203-11206, 2020 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32969426
18.
Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates.
Chem Asian J
; 15(6): 742-747, 2020 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32017414
19.
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
J Clin Invest
; 112(3): 407-14, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12897208
20.
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Cancer Res
; 63(24): 8922-9, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695209