Detalhe da pesquisa
1.
Stereoselective synthesis of 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as PIM kinase inhibitors inspired from marine alkaloids.
Chirality
; 34(11): 1437-1452, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35959859
2.
Identification of unprecedented ATP-competitive choline kinase inhibitors.
Bioorg Med Chem Lett
; 51: 128310, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416377
3.
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
Nat Chem Biol
; 9(9): 548-56, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23892893
4.
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.
Bioorg Med Chem
; 21(23): 7364-80, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139169
5.
The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding.
Mol Divers
; 16(1): 27-51, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22350112
6.
Molecular Dynamics Simulations of p97 Including Covalent, Allosteric and ATP-competitive Inhibitors.
Acta Chim Slov
; 66(2): 395-401, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33855508
7.
Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury.
Mol Cancer Ther
; 17(3): 603-613, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29237806
8.
Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.
J Med Chem
; 59(7): 3392-408, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27003761
9.
Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
J Med Chem
; 47(24): 6104-7, 2004 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15537364
10.
Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.
J Med Chem
; 62(17): 8364, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31424209
11.
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.
J Med Chem
; 56(2): 437-50, 2013 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245311
12.
Linear and nonlinear methods in modeling the aqueous solubility of organic compounds.
J Chem Inf Model
; 45(1): 170-6, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15667142
13.
Model based on GRID-derived descriptors for estimating CYP3A4 enzyme stability of potential drug candidates.
J Comput Aided Mol Des
; 18(3): 155-66, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15368916