Detalhe da pesquisa
1.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A
; 121(1): e2307086120, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147543
2.
Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.
J Immunol
; 202(7): 2017-2026, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745461
3.
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.
Hum Mol Genet
; 24(11): 3005-20, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25586491
4.
Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury.
Arch Biochem Biophys
; 532(1): 15-22, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23333631
5.
Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models.
Front Immunol
; 14: 1291990, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38179052
6.
Tregs in Autoimmunity: Insights Into Intrinsic Brake Mechanism Driving Pathogenesis and Immune Homeostasis.
Front Immunol
; 13: 932485, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35844555
7.
TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.
J Allergy Clin Immunol
; 134(4): 975-8.e5, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24954262
8.
Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A.
MAbs
; 12(1): 1770018, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32544369
9.
CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice.
J Pharmacol Exp Ther
; 328(1): 240-8, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18849357
10.
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model.
J Vis Exp
; (152)2019 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31736486
11.
Pharmacokinetics, Pharmacodynamics, Immunogenicity, Safety, and Tolerability of JNJ-61178104, a Novel Tumor Necrosis Factor-Alpha and Interleukin-17A Bispecific Antibody, in Healthy Subjects.
J Clin Pharmacol
; 59(7): 968-978, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30776134
12.
Alterations in soleus muscle gene expression associated with a metabolic endpoint following exercise training by lean and obese Zucker rats.
Physiol Genomics
; 29(3): 302-11, 2007 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17284668
13.
Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol Immunol
; 83: 92-99, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28119207
14.
Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice.
Endocrinology
; 146(5): 2200-9, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15705777
15.
GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice.
PLoS One
; 7(11): e49152, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23133675
16.
A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes.
Exp Diabetes Res
; 2011: 910159, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21754921
17.
Electrical stimulation of the isolated rat intestine in the presence of nutrient stimulus enhances glucagon-like peptide-1 release.
Physiol Meas
; 31(9): 1147-59, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20664162
18.
Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis.
Diabetes
; 57(7): 1926-34, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18426860