Detalhe da pesquisa
1.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445854
2.
Novel phenylalanine derived diamides as Factor XIa inhibitors.
Bioorg Med Chem Lett
; 26(2): 472-478, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704266
3.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073051
4.
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.
Bioorg Med Chem Lett
; 24(15): 3341-5, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24951330
5.
Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors.
Bioorg Med Chem Lett
; 18(2): 749-54, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18054227
6.
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
J Med Chem
; 50(22): 5339-56, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914785
7.
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
J Med Chem
; 60(23): 9703-9723, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29077405
8.
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.
J Med Chem
; 46(21): 4405-18, 2003 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14521405
9.
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.
Bioorg Med Chem Lett
; 16(21): 5584-9, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16963264
10.
1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Bioorg Med Chem Lett
; 16(15): 4141-7, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730984
11.
Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR.
Chem Res Toxicol
; 15(1): 48-62, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11800597