Detalhe da pesquisa
1.
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.
Blood
; 142(12): 1056-1070, 2023 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339579
2.
AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia.
Haematologica
; 107(6): 1311-1322, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732043
3.
Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML.
Blood
; 138(17): 1637-1641, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34232981
4.
Inhibition of menin, BCL-2, and FLT3 combined with a hypomethylating agent cures NPM1/FLT3-ITD/-TKD mutant acute myeloid leukemia in a patient-derived xenograft model.
Haematologica
; 108(9): 2513-2519, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727398
5.
Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Leukemia
; 38(4): 729-740, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38148395
6.
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Blood Cancer J
; 13(1): 57, 2023 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37088806
7.
Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias.
Sci Adv
; 9(48): eadh1436, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38019903
8.
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
Sci Rep
; 11(1): 12148, 2021 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34108527
9.
Correction: Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Leukemia
; 38(4): 926, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38459170
10.
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Blood Cancer J
; 13(1): 80, 2023 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37193700