Detalhe da pesquisa
1.
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.
PLoS Biol
; 20(3): e3001578, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35263320
2.
Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease.
Neurobiol Dis
; 190: 106376, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38092268
3.
Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease.
Neurobiol Dis
; 172: 105833, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35905928
4.
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Mol Psychiatry
; 26(9): 5441-5463, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32514103
5.
Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates.
Neurobiol Dis
; 141: 104951, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32439599
6.
Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates.
Neurobiol Dis
; 141: 104941, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32422281
7.
Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease.
Neurobiol Dis
; 141: 104943, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407769
8.
Corrigendum to "Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease" [Neurobiology of Disease, 2024 Jan:190:106376].
Neurobiol Dis
; 193: 106444, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38402018
9.
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.
Proc Natl Acad Sci U S A
; 113(7): E912-21, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26839406
10.
Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation.
J Biol Chem
; 292(9): 3919-3928, 2017 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28154193
11.
The many faces of α-synuclein: from structure and toxicity to therapeutic target.
Nat Rev Neurosci
; 14(1): 38-48, 2013 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23254192
12.
Correction: Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.
Mol Psychiatry
; 26(9): 5464, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32709993
13.
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.
J Biol Chem
; 290(15): 9412-27, 2015 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25657004
14.
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Hum Mol Genet
; 23(11): 2858-79, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412932
15.
Human-to-mouse prion-like propagation of mutant huntingtin protein.
Acta Neuropathol
; 132(4): 577-92, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27221146
16.
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.
Proc Natl Acad Sci U S A
; 110(41): E3945-54, 2013 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23983262
17.
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
J Biol Chem
; 289(32): 21856-76, 2014 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24936070
18.
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.
J Neurosci
; 32(5): 1536-44, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22302797
19.
Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons.
STAR Protoc
; 4(3): 102486, 2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37515763
20.
Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson's disease.
STAR Protoc
; 4(4): 102738, 2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991922