RESUMO
BACKGROUND: Serum lipoprotein(a) [Lp(a)] concentration is largely determined by variability at the apolipoprotein(a) gene locus. Most prominent effects relate to polymorphisms in the promoter (a pentanucleotide [PN] repeat) and coding regions (a kringle IV [K4] repeat), the latter of which also affects Lp(a) particle size. The impact of these polymorphisms on cardiovascular risk is poorly understood. METHODS AND RESULTS: We studied both polymorphisms and Lp(a) levels in 834 registry-based myocardial infarction (MI) patients (38% women) and 1548 population-based controls. Lp(a) concentrations were inversely related with the numbers of K4 and PN repeats. However, the effect of the PN polymorphism was restricted to subjects producing small Lp(a) particles (Assuntos
Apolipoproteínas/genética
, Lipoproteína(a)/sangue
, Lipoproteína(a)/genética
, Infarto do Miocárdio/sangue
, Infarto do Miocárdio/genética
, Polimorfismo Genético
, Apoproteína(a)
, Feminino
, Ligação Genética
, Genótipo
, Alemanha/epidemiologia
, Haplótipos
, Humanos
, Kringles/genética
, Modelos Logísticos
, Masculino
, Pessoa de Meia-Idade
, Infarto do Miocárdio/epidemiologia
, Razão de Chances
, Sequências Repetitivas de Ácido Nucleico/genética
, Risco