Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We review the possibilities, limitations, complementarity, and differences of reduced-order, biophysical models of arterial PW propagation, as well as theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information for vascular age assessment. We provide detailed mathematical derivations of these models and theoretical methods, showing how they are related to each other. Finally, we outline directions for future research to realize the potential of modeling and analysis of PW signals for accurate assessment of vascular age in both the clinic and in daily life.

Assessing hemodynamics from the photoplethysmogram to gain insights into vascular age: a review from VascAgeNet.

The photoplethysmogram (PPG) signal is widely measured by clinical and consumer devices, and it is emerging as a potential tool for assessing vascular age. The shape and timing of the PPG pulse wave are both influenced by normal vascular aging, changes in arterial stiffness and blood pressure, and atherosclerosis. This review summarizes research into assessing vascular age from the PPG. Three categories of approaches are described: 1) those which use a single PPG signal (based on pulse wave analysis), 2) those which use multiple PPG signals (such as pulse transit time measurement), and 3) those which use PPG and other signals (such as pulse arrival time measurement). Evidence is then presented on the performance, repeatability and reproducibility, and clinical utility of PPG-derived parameters of vascular age. Finally, the review outlines key directions for future research to realize the full potential of photoplethysmography for assessing vascular age.

Estimation of Heart Rate Recovery after StairClimbing Using aWrist-Worn Device.

Heart rate recovery (HRR) after physical exercise is a convenient method to assesscardiovascular autonomic function. Since stair climbing is a common daily activity, usually followedby a slow walking or rest, this type of activity can be considered as an alternative HRR test.The present study explores the feasibility to estimate HRR parameters after stair climbing usinga wrist-worn device with embedded photoplethysmography and barometric pressure sensors.A custom-made wrist-worn device, capable of acquiring heart rate and altitude, was used to estimatethe time-constant of exponential decay t, the short-term time constant S, and the decay of heart ratein 1 min D. Fifty-four healthy volunteers were instructed to climb the stairs at three different climbingrates. When compared to the reference electrocardiogram, the absolute and percentage errors werefound to be ≤ 21.0 s ( 52.7%) for τ, ≤ 0.14 (≤ 19.2%) for S, and ≤ 7.16 bpm (≤ 20.7%) for D in 75%of recovery phases available for analysis. The proposed approach to monitoring HRR parameters inan unobtrusive way may complement information provided by personal health monitoring devices(e.g., weight loss, physical activity), as well as have clinical relevance when evaluating the efficiencyof cardiac rehabilitation program outside the clinical setting.

Training Convolutional Neural Networks on Simulated Photoplethysmography Data: Application to Bradycardia and Tachycardia Detection.

Objective: To develop a method for detection of bradycardia and ventricular tachycardia using the photoplethysmogram (PPG). Approach: The detector is based on a dual-branch convolutional neural network (CNN), whose input is the scalograms of the continuous wavelet transform computed in 5-s segments. Training and validation of the CNN is accomplished using simulated PPG signals generated from RR interval series extracted from public ECG databases. Manually annotated real PPG signals from the PhysioNet/CinC 2015 Challenge Database are used for performance evaluation. The performance is compared to that of a pulse-based reference detector. Results: The sensitivity/specificity were found to be 98.1%/97.9 and 76.6%/96.8% for the CNN-based detector, respectively, whereas the corresponding results for the pulse-based detector were 94.7%/99.8 and 67.1%/93.8%, respectively. Significance: The proposed detector may be useful for continuous, long-term monitoring of bradycardia and tachycardia using wearable devices, e.g., wrist-worn devices, especially in situations where sensitivity is favored over specificity. The study demonstrates that simulated PPG signals are suitable for training and validation of a CNN.

High Specificity Wearable Device With Photoplethysmography and Six-Lead Electrocardiography for Atrial Fibrillation Detection Challenged by Frequent Premature Contractions: DoubleCheck-AF.

Background: Consumer smartwatches have gained attention as mobile health (mHealth) tools able to detect atrial fibrillation (AF) using photoplethysmography (PPG) or a short strip of electrocardiogram (ECG). PPG has limited accuracy due to the movement artifacts, whereas ECG cannot be used continuously, is usually displayed as a single-lead signal and is limited in asymptomatic cases. Objective: DoubleCheck-AF is a validation study of a wrist-worn device dedicated to providing both continuous PPG-based rhythm monitoring and instant 6-lead ECG with no wires. We evaluated its ability to differentiate between AF and sinus rhythm (SR) with particular emphasis on the challenge of frequent premature beats. Methods and Results: We performed a prospective, non-randomized study of 344 participants including 121 patients in AF. To challenge the specificity of the device two control groups were selected: 95 patients in stable SR and 128 patients in SR with frequent premature ventricular or atrial contractions (PVCs/PACs). All ECG tracings were labeled by two independent diagnosis-blinded cardiologists as "AF," "SR" or "Cannot be concluded." In case of disagreement, a third cardiologist was consulted. A simultaneously recorded ECG of Holter monitor served as a reference. It revealed a high burden of ectopy in the corresponding control group: 6.2 PVCs/PACs per minute, bigeminy/trigeminy episodes in 24.2% (31/128) and runs of ≥3 beats in 9.4% (12/128) of patients. AF detection with PPG-based algorithm, ECG of the wearable and combination of both yielded sensitivity and specificity of 94.2 and 96.9%; 99.2 and 99.1%; 94.2 and 99.6%, respectively. All seven false-positive PPG-based cases were from the frequent PVCs/PACs group compared to none from the stable SR group (P < 0.001). In the majority of these cases (6/7) cardiologists were able to correct the diagnosis to SR with the help of the ECG of the device (P = 0.012). Conclusions: This is the first wearable combining PPG-based AF detection algorithm for screening of AF together with an instant 6-lead ECG with no wires for manual rhythm confirmation. The system maintained high specificity despite a remarkable amount of frequent single or multiple premature contractions.

Detection of Walk Tests in Free-Living Activities Using a Wrist-Worn Device.

Exercise testing to assess the response to physical rehabilitation or lifestyle interventions is administered in clinics thus at best can be repeated only few times a year. This study explores a novel approach to collecting information on functional performance through walk tests, e.g., a 6-min walk test (6MWT), unintentionally performed in free-living activities. Walk tests are detected in step data provided by a wrist-worn device. Only those events of minute-to-minute variation in walking cadence, which is equal or lower than the empirically determined maximal SD (e.g., 5-steps), are considered as walk test candidates. Out of detected walk tests within the non-overlapping sliding time interval (e.g., 1-week), the one with the largest number of steps is chosen as the most representative. This approach is studied on a cohort of 99 subjects, assigned to the groups of patients with cardiovascular disease (CVD) and healthy subjects below and over 40-years-old, who were asked to wear the device while maintaining their usual physical activity regimen. The total wear time was 8,864 subject-days after excluding the intervals of occasionally discontinued monitoring. About 82% (23/28) of patients with CVD and 88% (21/24) of healthy subjects over 40-years-old had at least a single 6MWT over the 1st month of monitoring. About 52% of patients with CVD (12/23) and 91% (19/21) of healthy subjects over 40-years-old exceeded 500 m. Patients with CVD, on average, walked 46 m shorter 6MWT distance (p = 0.04) compared to healthy subjects. Unintentional walk testing is feasible and could be valuable for repeated assessment of functional performance outside the clinical setting.

Detection of atrial fibrillation using a wrist-worn device.

OBJECTIVE: This study proposes an algorithm for the detection of atrial fibrillation (AF), designed to operate on extended photoplethysmographic (PPG) signals recorded using a wrist-worn device of own design. APPROACH: Robustness against false alarms is achieved by means of signal quality assessment and different techniques for suppression of ectopic beats, bigeminy, and respiratory sinus arrhythmia. The decision logic is based on our previously proposed RR interval-based AF detector, but modified to account for differences between interbeat intervals in the ECG and the PPG. The detector is evaluated on simulated PPG signals as well as on clinical PPG signals recorded during cardiac rehabilitation after myocardial infarction. MAIN RESULTS: Analysis of the clinical signals showed that 1.5 false alarms were on average produced per day with a sensitivity of 72.0% and a specificity of 99.7% when 89.2% of the database was available for analysis, whereas as many as 15 when the RR interval-based AF detector, boosted by accelerometer information for signal quality assessment, was used. However, a sensitivity of 97.2% and a specificity of 99.6% were achieved when increasing the demands on signal quality so that 50% was available for analysis. SIGNIFICANCE: The proposed detector offers promising performance and is particularly well-suited for implementation in low-power wearable devices, e.g. wrist-worn devices, with significance in mass screening applications.

Atrial fibrillation frequency tracking in ambulatory ECG signals: The significance of signal quality assessment.

An approach to atrial fibrillation (AF) frequency tracking in long-term ambulatory ECG recordings is presented, comprising f-wave extraction, dominant atrial frequency (DAF) tracking, and signal quality assessment. Since poor signal quality is commonly encountered in ambulatory monitoring, a recently proposed index is employed to assess f-wave signal quality in a database containing 38 patients with permanent AF. The index ensures that DAF outliers, typically associated with poor-quality segments, are excluded from further analysis. 40% of all 5-s signal segments were excluded from the database due to poor quality. The exclusion of DAF outliers significantly reduces the standard deviation of the frequency estimates (p≤0.01), allowing more reliable evaluation of the difference between day- and night-time DAF. The results show that signal quality assessment plays a central role in DAF tracking, and therefore should be employed in ambulatory monitoring.

Assessment of pulse arrival time for arterial stiffness monitoring on body composition scales.

This study presents a system that aims to estimate changes in arterial health status in an unobtrusive way. It might be especially useful in long-term self-monitoring of cardiovascular performance for successful treatment and empowerment of patients. This system applies the electrocardiographic and impedance plethysmographic signals acquired using modified body composition scales for the calculation of pulse arrival time, which is directly related to arterial stiffness. The proposed device was tested in a cohort of 14 subjects. The modified scales were compared to the commercial PulsePen tonometer and the results showed significant relationship between these different devices (rs=0.93, p<0.01). The system also showed the ability to track small pulse arrival time variations induced by paced respiration. These findings suggest that scales evaluating parameters of cardiovascular function have potential to become a convenient device for self-monitoring of arterial stiffness.