Detalhe da pesquisa
1.
Nazo, the Drosophila homolog of the NBIA-mutated protein-c19orf12, is required for triglyceride homeostasis.
PLoS Genet
; 20(2): e1011137, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38335241
2.
Tissue-restricted inhibition of mTOR using chemical genetics.
Proc Natl Acad Sci U S A
; 119(38): e2204083119, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36095197
3.
Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.
PLoS Genet
; 17(2): e1008859, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539341
4.
Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression.
PLoS Genet
; 16(10): e1009118, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075064
5.
Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ.
PLoS Genet
; 14(11): e1007805, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30452458
6.
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles.
PLoS Genet
; 14(9): e1007694, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256786
7.
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.
PLoS Genet
; 12(3): e1005944, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27019408
8.
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
PLoS Genet
; 10(5): e1004279, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24874806
9.
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.
PLoS Genet
; 10(2): e1003974, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24516391
10.
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.
Proc Natl Acad Sci U S A
; 110(16): 6400-5, 2013 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23509287
11.
A Drosophila model for mechanistic investigation of tau protein spread.
bioRxiv
; 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712083
12.
Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium.
Cell Metab
; 5(3): 195-205, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17339027
13.
The PINK1/Parkin pathway regulates mitochondrial morphology.
Proc Natl Acad Sci U S A
; 105(5): 1638-43, 2008 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18230723
14.
Slowed Protein Turnover in Aging Drosophila Reflects a Shift in Cellular Priorities.
J Gerontol A Biol Sci Med Sci
; 76(10): 1734-1739, 2021 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33453098
15.
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
J Neurosci
; 28(2): 465-72, 2008 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18184789
16.
The PINK1/Parkin pathway: a mitochondrial quality control system?
J Bioenerg Biomembr
; 41(6): 499-503, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19967438
17.
Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective.
Autophagy
; 15(9): 1592-1605, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30865561
18.
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.
Nat Commun
; 10(1): 3280, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31337756
19.
Parkin: a multipurpose neuroprotective agent?
Neuron
; 38(1): 13-6, 2003 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12691660
20.
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
Curr Biol
; 15(17): 1572-7, 2005 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16139213