Detalhe da pesquisa
1.
In silico drug discovery: solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm.
Clin Pharmacol Ther
; 81(1): 30-4, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17185996
2.
Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes.
Clin Pharmacol Ther
; 82(3): 282-93, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17443135
3.
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Curr Alzheimer Res
; 4(4): 386-96, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17908041
4.
Flavopiridol binds to duplex DNA.
Cancer Res
; 60(9): 2419-28, 2000 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-10811119
5.
Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.
Protein Sci
; 9(10): 1857-65, 2000 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-11106157
6.
Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
Protein Sci
; 3(10): 1770-8, 1994 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-7849595
7.
Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.
FEBS Lett
; 502(3): 93-7, 2001 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-11583118
8.
A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it.
Curr Med Chem
; 8(8): 933-9, 2001 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-11375760
9.
In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier.
Neuropharmacology
; 38(7): 1027-34, 1999 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-10428421
10.
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
J Med Chem
; 42(20): 4225-31, 1999 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-10514292
11.
Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
J Med Chem
; 43(3): 401-8, 2000 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-10669567
12.
Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.
J Med Chem
; 35(9): 1634-8, 1992 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-1315871
13.
Synthesis and evaluation of novel aldose reductase inhibitors: Effects on lens protein kinase Cgamma.
Mol Vis
; 7: 164-71, 2001 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11483892
14.
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.
Neuroreport
; 10(4): 789-93, 1999 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-10208549
15.
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.
Neuroreport
; 10(4): 795-800, 1999 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-10208550
16.
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Neurosci Lett
; 288(2): 95-8, 2000 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-10876069
17.
[Long-term surveillance after basic elimination of bancroftian filariasis].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 11(1): 21-4, 1993.
Artigo
em Zh
| MEDLINE | ID: mdl-8403271
18.
Molar pregnancy with false negative urine hCG: the hook effect.
Singapore Med J
; 51(3): e58-61, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20428735
19.
Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
J Med Chem
; 34(12): 3399-402, 1991 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-1766006
20.
Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method.
Proteins
; 45(3): 183-9, 2001 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11599021