Design of Optimal Coils for Deep Transcranial Magnetic Stimulation.

In this work, a stream function inverse boundary element method (IBEM) has been used for designing different deep transcranial magnetic stimulation (dTMS)coils to activate the prefrontal cortex and the temporal lobe have been set as the target regions. In addition, the performances of these coils have been described and the electric field induced by them has been obtained by using a computational forward technique. These results show that the stream function IBEM is an ideal approach to design optimal dTMS coils capable of producing deep stimulation in the target brain regions. Clinical relevance - The design problem proposed here can be used to produce efficient dTMS stimulators for neurological disorders, which can overcome some of the currently existing limitations of the most common devices employed in TMS.

Design of TMS coils with reduced Lorentz forces: application to concurrent TMS-fMRI.

OBJECTIVE: Interleaving TMS (transcranial magnetic stimulation) with fMRI (functional Magnetic Resonance Imaging) is a promising technique to study functional connectivity in the human brain, but its development is being restricted by technical limitations, such as that due to the interaction of the TMS current pulses with the magnetic fields of an MRI scanner. In this work, a TMS coil design method capable of controlling Lorentz forces experienced by the coil in the presence of static magnetic fields is presented. APPROACH: The suggested approach is based on an existing inverse boundary element method (IBEM) for TMS coil design, in which new electromagnetic computational models of the Lorentz forces have been included to be controlled in the design process. MAIN RESULTS: To demonstrate the validity of this technique, it has been used for the design and simulation of TMS coils wound on rectangular flat, spherical and hemispherical surfaces with improved mechanical stability. The obtained results confirm that TMS coils with reduced Lorentz forces inside the static main field of an MRI scanner can be produced, which is achieved to the detriment of other coil performance parameters. SIGNIFICANCE: The proposed approach provides an efficient tool to design TMS stimulators of a wide range of coil geometries with improved mechanical stability, which can be extremely useful to overcome current limitations for interleaved TMS-fMRI.