Detalhe da pesquisa
1.
Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.
Circ Res
; 120(12): 1903-1915, 2017 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461455
2.
Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations.
Hum Mol Genet
; 24(20): 5867-79, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26220971
3.
Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-ß.
Hum Mol Genet
; 22(15): 3123-37, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591991
4.
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
Am J Hum Genet
; 84(5): 617-27, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19409525
5.
MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment.
Circ Res
; 117(2): 109-12, 2015 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26139854
6.
Genetic variants promoting smooth muscle cell proliferation can result in diffuse and diverse vascular diseases: evidence for a hyperplastic vasculomyopathy.
Genet Med
; 12(4): 196-203, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130469
7.
Pathogenesis of thoracic and abdominal aortic aneurysms.
Ann N Y Acad Sci
; 1085: 339-52, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17182954
8.
Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.
Sci Signal
; 8(399): ra105, 2015 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26486174
9.
Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.
Matrix Biol
; 37: 142-9, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24613575
10.
Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.
Sci Transl Med
; 5(183): 183ra58, 1-11, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23636094
11.
Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.
Annu Rev Genomics Hum Genet
; 9: 283-302, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18544034
12.
Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and sporadic aneurysms.
J Thorac Cardiovasc Surg
; 136(4): 922-9, 929.e1, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954631
13.
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.
Hum Mol Genet
; 16(20): 2453-62, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17666408
14.
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.
Nat Genet
; 39(12): 1488-93, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994018