Detalhe da pesquisa
1.
Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
Eur Arch Psychiatry Clin Neurosci
; 273(7): 1463-1476, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890259
2.
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.
Int J Mol Sci
; 23(20)2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293063
3.
Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone'.
Mol Psychiatry
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38806691
4.
REL-1017 (Esmethadone) May Rapidly Reduce Dissociative Symptoms in Adults With Major Depressive Disorder Unresponsive to Standard Antidepressants: A Report of 2 Cases.
J Clin Psychopharmacol
; 42(5): 503-506, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35943402
5.
Effect of Time From Onset of Major Depressive Disorder on the Therapeutic Response to Esmethadone (REL-1017).
J Clin Psychiatry
; 85(2)2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38767937
6.
Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder.
Prim Care Companion CNS Disord
; 25(1)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821775
7.
Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.
Drugs R D
; 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010591
8.
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Transl Psychiatry
; 13(1): 192, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286536
9.
A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time.
Pain Pract
; 12(8): 610-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22304620
10.
REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats.
Front Pharmacol
; 13: 863959, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35571103
11.
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.
Pharmaceuticals (Basel)
; 15(7)2022 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35890179
12.
REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.
Sci Rep
; 12(1): 11389, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35794162
13.
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.
Pharmaceuticals (Basel)
; 15(8)2022 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36015145
14.
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Am J Psychiatry
; 179(2): 122-131, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34933568
15.
Managing osteoarthritis and joint pain at work: helping the primary care physician educate patients who rely on non-prescription NSAIDs.
G Ital Med Lav Ergon
; 33(2): 193-200, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21796924
16.
REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.
Front Pharmacol
; 12: 671859, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33995104
17.
The addition of tramadol as a second opioid may improve pain relief in severe osteoarthritis: a prospective study.
Pain Pract
; 10(6): 540-7, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21040441
18.
Preliminary observations of a novel topical oil with analgesic properties for treatment of acute and chronic pain syndromes.
Pain Pract
; 10(3): 201-13, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20230451
19.
Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?
Clin J Pain
; 24(2): 142-54, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18209521
20.
Does ultrasound guidance facilitate facial botulinum injections?
Headache
; 53(2): 382-3, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23432444