RESUMO
We report the case of an adolescent boy with aquagenic urticaria unresponsive to oral antihistamine therapy. We successfully treated his condition by topical application of a petrolatum-containing cream as a protective coating. To our knowledge, this is the first report showing the use of topical therapy alone to treat aquagenic urticaria in a child. Based on the effectiveness, safety profile, and ease of use, clinicians may wish to consider this regimen as a first-line therapy.
Assuntos
Vaselina/administração & dosagem , Creme para a Pele/administração & dosagem , Urticária/tratamento farmacológico , Urticária/etiologia , Água/efeitos adversos , Adolescente , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Humanos , Masculino , Urticária Crônica InduzidaRESUMO
A 31-year-old Caucasian male with leukocyte adhesion deficiency I and a 20-year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade.
Assuntos
Imunoglobulinas Intravenosas/administração & dosagem , Síndrome da Aderência Leucocítica Deficitária/terapia , Pioderma Gangrenoso/terapia , Úlcera Cutânea/terapia , Adulto , Humanos , Síndrome da Aderência Leucocítica Deficitária/imunologia , Síndrome da Aderência Leucocítica Deficitária/patologia , Masculino , Pioderma Gangrenoso/imunologia , Pioderma Gangrenoso/patologia , Úlcera Cutânea/imunologia , Úlcera Cutânea/patologiaRESUMO
Mucous membrane plasmacytosis is a rare, often idiopathic, inflammatory disorder that frequently presents as an erythematous, velvety, or lobulated plaque on a mucosal surface. While mucous membrane plasmacytosis often runs a benign course, plaques are known to erode, ulcerate, and bleed. Moreover, according to a recent review of mucous membrane plasmacytosis, treatments of this disorder are inconsistently successful. We report a case of erosive, hemorrhagic mucous-membrane plasmacytosis of the lips treated successfully with cryotherapy. To the best of our knowledge, this case represents the second case of mucous membrane plasmacytosis successfully treated with cryotherapy. The long term response of our patient's condition to cryotherapy with no functional side effects may warrant further study of this technique for severe erosive mucous membrane plasmacytosis.