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1.
Sensors (Basel) ; 23(21)2023 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-37960655

RESUMO

Vessels frequently encounter challenging marine conditions that expose the propeller-hull to corrosive water and marine fouling. These challenges necessitate innovative approaches to optimize propeller-hull performance. This study aims to assess a method for predicting propeller-hull degradation. The proposed solution revolves around an innovative Key Performance Indicator (KPI) based on Artificial Neural Networks (ANNs). Our objective is to validate the findings; thus, a thorough comparison is conducted between the proposed method and the baseline solution derived from the ISO-19030. Emphasis is placed on determining the optimal parameters for computing the KPI, which involves applying various features, filters, and pre-processing techniques. The proposed method is tested on real data collected by an Internet of Things (IoT) system installed in different types of vessels. Four distinct experiments with ANNs are conducted. Results demonstrate that the ANN-based indicator offers greater accuracy in predicting propeller-hull degradation compared to the baseline method. Additionally, it is demonstrated that selecting a diverse set of features and implementing consistent filtering and preprocessing techniques enhance the performance of the traditional indicator. The utilization of Deep Learning (DL) in the maritime industry is of great significance, as it enables a comprehensive and dynamic assessment of predictive maintenance of the propeller-hull. The DL index method holds potential for diverse maintenance applications, providing a holistic platform with anticipated environmental and financial benefits.

2.
Acta Neurochir (Wien) ; 164(2): 321-329, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34854994

RESUMO

BACKGROUND: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogenous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear, and there are several controversies. The aim of this paper is to provide insight into the main principles defining management and surgical strategy, in order to formulate a series of recommendations. METHODS: A task force was created by the EANS skull base section committee along with its members and other renowned experts in the field to generate recommendations for the surgical management of these tumours on a European perspective. To achieve this, the task force performed an extensive systematic review in this field and had discussions within the group. This article is the third of a three-part series describing non-vestibular schwannomas (IX, X, XI, XII). RESULTS: A summary of literature evidence was proposed after discussion within the EANS skull base section. The constituted task force dealt with the practice patterns that exist with respect to preoperative radiological investigations, ophthalmological assessments, optimal surgical and radiotherapy strategies and follow-up management. CONCLUSION: This article represents the consensually derived opinion of the task force with respect to the treatment of non-vestibular schwannomas. For each of these tumours, the management paradigm is shifting towards the compromise between function preservation and progression free survival.


Assuntos
Neoplasias dos Nervos Cranianos , Forâmen Jugular , Neurilemoma , Adulto , Neoplasias dos Nervos Cranianos/diagnóstico por imagem , Neoplasias dos Nervos Cranianos/cirurgia , Nervos Cranianos/patologia , Humanos , Neurilemoma/diagnóstico por imagem , Neurilemoma/patologia , Neurilemoma/cirurgia , Base do Crânio/diagnóstico por imagem , Base do Crânio/patologia , Base do Crânio/cirurgia
3.
Acta Neurochir (Wien) ; 164(2): 285-297, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34755208

RESUMO

BACKGROUND: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogeneous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear, and there are several controversies. The aim of this paper is to provide insight into the main principles defining management and surgical strategy, in order to formulate a series of recommendations. METHODS: A task force was created by the EANS skull base section along with its members and other renowned experts in the field to generate recommendations for the surgical management of these tumours on a European perspective. To achieve this, the task force performed an extensive systematic review in this field and had discussions within the group. This article is the first of a three-part series describing non-vestibular schwannomas (I, II, III, IV, VI). RESULTS: A summary of literature evidence was proposed after discussion within the EANS skull base section. The constituted task force dealt with the practice patterns that exist with respect to pre-operative radiological investigations, ophthalmological assessments, optimal surgical and radiotherapy strategies and follow-up management. CONCLUSION: This article represents the consensually derived opinion of the task force with respect to the treatment of non-vestibular schwannomas. For each of these tumours, the management of these patients is complex, and for those which are symptomatic tumours, the paradigm is shifting towards the compromise between function preservation and progression-free survival.


Assuntos
Neurilemoma , Radiocirurgia , Adulto , Consenso , Humanos , Neurilemoma/cirurgia , Radiocirurgia/métodos , Base do Crânio/cirurgia
4.
Acta Neurochir (Wien) ; 164(2): 299-319, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35079891

RESUMO

BACKGROUND: Non-vestibular schwannomas are relatively rare, with trigeminal and jugular foramen schwannomas being the most common. This is a heterogenous group which requires detailed investigation and careful consideration to management strategy. The optimal management for these tumours remains unclear and there are several controversies. The aim of this paper is to provide insight into the main principles defining management and surgical strategy, in order to formulate a series of recommendations. METHODS: A task force was created by the EANS skull base section committee along with its members and other renowned experts in the field to generate recommendations for the surgical management of these tumours on a European perspective. To achieve this, the task force performed an extensive systematic review in this field and had discussions within the group. This article is the second of a three-part series describing non-vestibular schwannomas (V, VII). RESULTS: A summary of literature evidence was proposed after discussion within the EANS skull base section. The constituted task force dealt with the practice patterns that exist with respect to pre-operative radiological investigations, ophthalmological assessments, optimal surgical and radiotherapy strategies, and follow-up management. CONCLUSION: This article represents the consensually derived opinion of the task force with respect to the treatment of trigeminal and facial schwannoma. The aim of treatment is maximal safe resection with preservation of function. Careful thought is required to select the appropriate surgical approach. Most middle fossa trigeminal schwannoma tumours can be safely accessed by a subtemporal extradural middle fossa approach. The treatment of facial nerve schwannoma remains controversial.


Assuntos
Neoplasias dos Nervos Cranianos , Neurilemoma , Adulto , Consenso , Neoplasias dos Nervos Cranianos/cirurgia , Nervo Facial , Humanos , Neurilemoma/cirurgia , Estudos Retrospectivos , Base do Crânio/cirurgia , Resultado do Tratamento
5.
Acta Neurochir (Wien) ; 163(11): 3131-3142, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34365544

RESUMO

Aggressive pituitary neuroendocrine tumors (APT) account for 10% of pituitary tumors. Their management is a rapidly evolving field of clinical research and has led pituitary teams to shift toward a neuro-oncological-like approach. The new terminology "Pituitary neuroendocrine tumors" (PitNet) that was recently proposed to replace "pituitary adenomas" reflects this change of paradigm. In this narrative review, we aim to provide a state of the art of actual knowledge, controversies, and recommendations in the management of APT. We propose an overview of current prognostic markers, including the recent five-tiered clinicopathological classification. We further establish and discuss the following recommendations from a neurosurgical perspective: (i) surgery and multi-staged surgeries (without or with parasellar resection in symptomatic patients) should be discussed at each stage of the disease, because it may potentialize adjuvant medical therapies; (ii) temozolomide is effective in most patients, although 30% of patients are non-responders and the optimal timeline to initiate and interrupt this treatment remains questionable; (iii) some patients with selected clinicopathological profiles may benefit from an earlier local radiotherapy and/or chemotherapy; (iv) novel therapies such as VEGF-targeted therapies and anti-CTLA-4/anti-PD1 immunotherapies are promising and should be discussed as 2nd or 3rd line of treatment. Finally, whether neurosurgeons have to operate on "pituitary adenomas" or "PitNets," their role and expertise remain crucial at each stage of the disease, prompting our community to deal with evolving concepts and therapeutic resources.


Assuntos
Adenoma , Tumores Neuroendócrinos , Neoplasias Hipofisárias , Humanos , Hipófise , Neoplasias Hipofisárias/cirurgia , Base do Crânio
6.
Acta Neurochir (Wien) ; 162(11): 2595-2617, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32728903

RESUMO

BACKGROUND AND OBJECTIVE: The optimal management of large vestibular schwannomas continues to be debated. We constituted a task force comprising the members of the EANS skull base committee along with international experts to derive recommendations for the management of this problem from a European perspective. MATERIAL AND METHODS: A systematic review of MEDLINE database, in compliance with the PRISMA guidelines, was performed. A subgroup analysis screening all surgical series published within the last 20 years (January 2000 to March 2020) was performed. Weighted summary rates for tumor resection, oncological control, and facial nerve preservation were determined using meta-analysis models. This data along with contemporary practice patterns were discussed within the task force to generate consensual recommendations regarding preoperative evaluations, optimal surgical strategy, and follow-up management. RESULTS: Tumor classification grades should be systematically used in the perioperative management of patients, with large vestibular schwannomas (VS) defined as > 30 mm in the largest extrameatal diameter. Grading scales for pre- and postoperative hearing (AAO-HNS or GR) and facial nerve function (HB) are to be used for reporting functional outcome. There is a lack of consensus to support the superiority of any surgical strategy with respect to extent of resection and use of adjuvant radiosurgery. Intraoperative neuromonitoring needs to be routinely used to preserve neural function. Recommendations for postoperative clinico-radiological evaluations have been elucidated based on the surgical strategy employed. CONCLUSION: The main goal of management of large vestibular schwannomas should focus on maintaining/improving quality of life (QoL), making every attempt at facial/cochlear nerve functional preservation while ensuring optimal oncological control, thereby allowing to meet patient expectations. Despite the fact that this analysis yielded only a few Class B evidences and mostly expert opinions, it will guide practitioners to manage these patients and form the basis for future clinical trials.


Assuntos
Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos/métodos , Qualidade de Vida , Base do Crânio/cirurgia , Consenso , Audição , Humanos , Microcirurgia/métodos , Complicações Pós-Operatórias/prevenção & controle , Radiocirurgia/métodos , Resultado do Tratamento
7.
Surg Innov ; 23(6): 613-619, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27448557

RESUMO

OBJECTIVE: Aim of this study was to develop a prototype for an innovative, burr-hole mounted device, for stabilizing endoscopes during intracranial surgery. The objective was an easily maneuverable device, freeing one hand without compromising flexibility and safety. This could avoid the need for a second surgeon or a bulky holder, thus improving coordination. METHODS: The initial concept arose from the observation that intraventricular endoscopy is often performed by 2 surgeons, 1 navigating the endoscope and 1 inserting/handling instruments through the working channel. A specification analysis was performed. Desired properties were specified through a literature review, as well as informal interviews with surgeons and engineers. Tools used for the design included blueprints, 3-dimensional computer aided-design and cooperating with engineers. The final prototype was 3D-printed and the toruses were produced with molding. RESULTS: A prototype named BuESta (Burr hole Endoscope Stabililizer) was produced. This consists of 2 half hollow sphere parts and interchangeable toruses and has the following features: easy to produce, inexpensive, not prolonging surgical time, semirigid, variable fixation, easy to fix/release, safe, no bulky articulated arms, mimicking basic concepts of second hand fixation (index finger/thumb fixation, hand resting/stabilizing on skull). CONCLUSIONS: This work represents a feasibility study including specification analysis, design and prototyping of a novel Burr hole endoscope stabilizing device. The device offers variable support for the endoscope, from complete free-hand to semirigid to rigid, thus freeing one hand which is often used to stabilize the endoscope. It can potentially help achieve solo surgery.


Assuntos
Ventrículos Cerebrais/cirurgia , Desenho Assistido por Computador , Endoscopia/instrumentação , Neuroendoscopia/instrumentação , Endoscopia/métodos , Desenho de Equipamento , Segurança de Equipamentos , Humanos , Imageamento Tridimensional , Neuroendoscópios/classificação , Procedimentos Neurocirúrgicos/instrumentação , Procedimentos Neurocirúrgicos/métodos
8.
Childs Nerv Syst ; 29(11): 1985-91, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23812629

RESUMO

INTRODUCTION: The aim of this study was to report a rare pediatric case of spontaneous spinal epidural hematoma (SSEH) mimicking Guillain-Barré syndrome (GBS), secondary to an epidural arteriovenous malformation (AVM). Furthermore, a case-based update and insight into the entity is attempted. METHODS: An 8-year-old male presented with progressing severe lower limb weakness and no traumatic history. Presentation was mimicking GBS with ascending symptoms. Magnetic resonance (MR) scan revealed a dorsal epidural mass, extending from C6-C7 to T2, compressing the spinal cord. Emergency laminoplasties and surgical evacuation of the hematoma were performed. An up-to-date review of reported SSEH cases in children was conducted, with emphasis on underlying vascular malformations (epidural AVMs in particular). Pathogenesis, predisposing factors, imaging, diagnosis, treatment and outcome are discussed. RESULTS: The hematoma was successfully evacuated. A vascular membrane on the dura was peeled off and sent for histopathology. There was no evidence of intradural vascular penetration. The patient improved postoperatively and was able to walk with support 7 months later. Histology revealed closely packed thin-walled angiomatous structures with wide lumens (filled with red blood cells) with walls composed of collagen and smooth muscle fibers, findings consistent with AVM. CONCLUSIONS: Non-traumatic SSEH is rare in the pediatric population. Although vascular malformations are suspected, they are extremely rarely identified histopathologically. This case represents one of the very few reports of pediatric SSEH caused by a histologically proven, purely epidural AVM. High index of clinical suspicion and low threshold for MR can lead to timely diagnosis and prompt treatment with good functional outcome.


Assuntos
Malformações Arteriovenosas/complicações , Dura-Máter/patologia , Hematoma Epidural Espinal/etiologia , Compressão da Medula Espinal/etiologia , Malformações Arteriovenosas/patologia , Criança , Dura-Máter/cirurgia , Hematoma Epidural Espinal/cirurgia , Humanos , Laminectomia , Imageamento por Ressonância Magnética , Masculino , Compressão da Medula Espinal/cirurgia , Resultado do Tratamento
9.
Brain Spine ; 3: 101740, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37383436

RESUMO

Introduction: and Research Question: Invasive growth of meningiomas into CNS tissue is rare but of prognostic significance. While it has entered the WHO classification as a stand-alone criterion for atypia, its true prognostic impact remains controversial. Retrospective analyses, on which the current evidence is based, show conflicting results. Discordant findings might be explained by different intraoperative sampling methodologies. Material and methods: To assess the applied sampling methods in the light of the novel prognostic impact of CNS invasion, an anonymous survey was designed and distributed via the EANS website and newsletter. The survey was open from June 5th until July 15th, 2022. Results: After exclusion of 13 incomplete responses, 142 (91.6%) datasets were used for statistical analysis. Only 47.2% of participants' institutions utilize a standardized sampling method, and 54.9% pursue a complete sampling of the area of contact between the meningioma surface and CNS tissue. Most respondents (77.5%) did not change their sampling practice after introduction of the new grading criteria to the WHO classification of 2016. Intraoperative suspicion of CNS invasion changes the sampling for half of the participants (49.3%). Additional sampling of suspicious areas of interest is reported in 53.5%. Dural attachment and adjacent bone are more readily sampled separately if tumor invasion is suspected (72.5% and 74.6%, respectively), compared to meningioma tissue with signs of CNS invasion (59.9%). Discussion and conclusions: Intraoperative sampling methods during meningioma resection vary among neurosurgical departments. There is need for a structured sampling to optimize the diagnostic yield of CNS invasion.

10.
Brain Spine ; 3: 102687, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38021006

RESUMO

Introduction and research question: The use of an endoscope in skull base surgery provides a panoramic close-up view over the intracranial structures from multiple angles with excellent illumination, thus permitting greater extent of resection of tumors arising at sellar area, mostly represented by PitNet - Pituitary neuroendocrine tumors, with higher likelihood of preserving vital/intact gland tissue. For this refined specialty of neurosurgery, unique skills need to be acquired along a steep learning curve. Material and methods: EANS (European Association of Neurosurgical Societies) skull base section panelists were enrolled and 11 completed the survey: the goal was to provide a consensus statement of the endoscopic endonasal approach for pituitary adenoma surgery. Results: The survey consisted of 44 questions covering demographics data (i.e., academic/non-academic center, case load, years of experience), surgical techniques (i.e., use of neuronavigation, preoperative imaging), and follow-up management. Discussion and conclusions: In this paper we identified a series of tips and tricks at different phases of an endoscopic endonasal pituitary surgery procedure to underline the crucial steps to perform successful surgery and reduce complications: we took in consideration the principles of the surgical technique, the knowledge of the anatomy and its variations, and finally the importance of adjoining specialties experts.

11.
Brain Spine ; 2: 100864, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36248124

RESUMO

Introduction: The evolution of cavernous sinus meningiomas (CSMs) might be unpredictable and the efficacy of their treatments is challenging due to their indolent evolution, variations and fluctuations of symptoms, heterogeneity of classifications and lack of randomized controlled trials. Here, a dedicated task force provides a consensus statement on the overall management of CSMs. Research question: To determine the best overall management of CSMs, depending on their clinical presentation, size, and evolution as well as patient characteristics. Material and methods: Using the PRISMA 2020 guidelines, we included literature from January 2000 to December 2020. A total of 400 abstracts and 77 titles were kept for full-paper screening. Results: The task force formulated 8 recommendations (Level C evidence). CSMs should be managed by a highly specialized multidisciplinary team. The initial evaluation of patients includes clinical, ophthalmological, endocrinological and radiological assessment. Treatment of CSM should involve experienced skull-base neurosurgeons or neuro-radiosurgeons, radiation oncologists, radiologists, ophthalmologists, and endocrinologists. Discussion and conclusion: Radiosurgery is preferred as first-line treatment in small, enclosed, pauci-symptomatic lesions/in elderly patients, while large CSMs not amenable to resection or WHO grade II-III are candidates for radiotherapy. Microsurgery is an option in aggressive/rapidly progressing lesions in young patients presenting with oculomotor/visual/endocrinological impairment. Whenever surgery is offered, open cranial approaches are the current standard. There is limited experience reported about endoscopic endonasal approach for CSMs and the main indication is decompression of the cavernous sinus to improve symptoms. Whenever surgery is indicated, the current trend is to offer decompression followed by radiosurgery.

12.
Brain Spine ; 2: 100878, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36248137

RESUMO

Introduction: The optimal surgical treatment for giant pituitary neuroendocrine tumors(GPitNETs) is debated. Research question: The aim of this paper is to optimize the surgical management of these patients and to provide a consensus statement on behalf of the EANS Skull Base Section. Material and methods: We constituted a task force belonging to the EANS skull base committee to define some principles for the management of GPitNETs. A systematic review was performed according to PRISMA guidelines to perform a meta-analysis on surgical series of GPitNETs. Weighted summary rates were obtained for the pooled extent of resection and according to the surgical technique. These data were discussed to obtain recommendations after evaluation of the selected articles and discussion among the experts. Results: 20articles were included in our meta-analysis, for a total of 1263 patients. The endoscopic endonasal technique was used in 40.3% of cases, the microscopic endonasal approach in 34% of cases, transcranial approaches in 18.7% and combined approaches in 7% of cases. No difference in terms of gross total resection (GTR) rate was observed among the different techniques. Pooled GTR rate was 36.6%, while a near total resection (NTR) was possible in 45.2% of cases. Cavernous sinus invasion was associated with a lower GTR rate (OR: 0.061). After surgery, 35% of patients had endocrinological improvement and 75.6% had visual improvement. Recurrent tumors were reported in 10% of cases. Discussion and conclusion: After formal discussion in the working group, we recommend the treatment of G-PitNETs tumors with a more complex and multilobular structure in tertiary care centers. The endoscopic endonasal approach is the first option of treatment and extended approaches should be planned according to extension, morphology and consistency of the lesion. Transcranial approaches play a role in selected cases, with a multicompartmental morphology, subarachnoid invasion and extension lateral to the internal carotid artery and in the management of residual tumor apoplexy.

13.
Brain Spine ; 2: 101661, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36605386

RESUMO

•OGM surgery is much more complex than a simple debate of "from above or from below" (transcranial vs endoscopic).•Lateral Sub-frontal and Superior Interhemispheric seem the most effective, superior and versatile approaches for OGM.•Minimally Invasive Transcranial approaches showed no inferiority in OGM sized <4 â€‹cm.•Endoscopic Endonasal Approaches showed inferior results in surgical and in functional outcomes for OGM.

14.
Childs Nerv Syst ; 27(3): 429-38, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20711593

RESUMO

OBJECTIVE: Arachnoid cysts occupying the suprasellar region comprise 10-15% of intracranial distribution. Unlike large suprasellar cysts, pure interpeduncular cysts (IPCs) are rare, and their natural history is unknown. We describe a small series of children diagnosed with IPC and their long-term natural history. METHODS: A retrospective review was conducted of interpeduncular arachnoid cysts diagnosed over the years 2000-2010 at our center. Patients with clearly suprasellar cysts were excluded. Serial magnetic resonance imaging and long-term follow-up examinations were analyzed. Additionally, we conducted an extensive literature review focusing on the differences between suprasellar cysts and IPCs. RESULTS: We identified three pediatric patients with "pure" IPC; all of these had a follow-up of more than 5 years, and none was operated. Only six additional cases were identified in the literature. In both our experience and in the literature review, IPCs proved stable over the course of time, both radiologically as well as clinically. CONCLUSIONS: The clinical and radiological features of IPCs are not well defined. Variations in the relationship of arachnoid cysts in this area to Liliequist's membrane may explain the different subgroups that have been identified as well as the confusing nomenclature. IPCs are usually diagnosed as incidental findings or present with mild endocrine disorders. Associated findings of hydrocephalus, mass effect, and compression of neighboring structures, such as the chiasm, are not as frequent as with suprasellar cysts. Given the high likelihood of continuing stability, a conservative strategy of follow-up is recommended for pure IPCs that demonstrate preservation of the third ventricle.


Assuntos
Cistos Aracnóideos/diagnóstico , Tegmento Mesencefálico/patologia , Cistos Aracnóideos/cirurgia , Criança , Feminino , Seguimentos , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Gravidez , Diagnóstico Pré-Natal , Tegmento Mesencefálico/diagnóstico por imagem , Tegmento Mesencefálico/cirurgia , Resultado do Tratamento , Ultrassonografia
15.
Childs Nerv Syst ; 27(2): 303-11, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20419304

RESUMO

INTRODUCTION: Cavernous angiomas (CA) are congenital intraparenchymal vascular malformations that contain sinusoidal spaces lined by a single-layer endothelium, separated by collagenous stroma with no intervening brain parenchyma. Despite the congenital origin of CA, they rarely present in the neonatal and prenatal period. In this paper, we present a case report of a neonatal suprasellar CA that presented with a bleed. We also present a literature review focusing on specific features of intracranial CA in the neonatal and fetal age groups. CASE REPORT: A 27-day-old neonate presented with a left eye ptosis for 2 days, followed by a generalized seizure. A head computed tomography revealed a suprasellar hematoma with intraventricular and subarachnoid extension. Brain magnetic resonance imaging revealed hemorrhages of various ages. Magnetic resonance angiography did not reveal any vascular malformation. Surgical exploration of the suprasellar mass revealed a capsulated dense hematoma. Postoperatively, the neonate was weaned of artificial ventilation over a protracted period and remained hemiparetic with signs of third nerve palsy. Pathology revealed a CA. CA presenting as a suprasellar bleed with subarachnoid and intraventricular extension is very rare especially among neonates. To the best of our knowledge, 20 cases of CA have been reported in the neonatal and fetal period in the English literature. Neonatal CA in general and suprasellar location in particular are extremely rare lesions. Neonatal/fetal CA seems to present more aggressively and have a worse prognosis compared to those presenting at a later age.


Assuntos
Neoplasias Encefálicas/complicações , Hemangioma Cavernoso do Sistema Nervoso Central/complicações , Hemorragias Intracranianas/etiologia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/cirurgia , Hemangioma Cavernoso do Sistema Nervoso Central/patologia , Hemangioma Cavernoso do Sistema Nervoso Central/cirurgia , Humanos , Recém-Nascido , Hemorragias Intracranianas/patologia , Hemorragias Intracranianas/cirurgia , Masculino
16.
Childs Nerv Syst ; 27(2): 313-21, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20461521

RESUMO

INTRODUCTION: Pilomyxoid astrocytoma (PMA) is a recently described glial tumor with similarities to pilocytic astrocytomas, yet with distinct histopathological characteristics and a more aggressive behavior. It occurs predominantly in the hypothalamic/chiasmatic region. Only four patients with spinal cord PMA have been reported in the pediatric population. The 2007 WHO Working Group recognized PMA as a new variant and recommended an assignment to WHO grade II. OBJECTIVE: The purpose of this paper was to report a rare location, address the aggressive behavior and rapid progression, and based on the specific patient, to review the literature and discuss current treatment strategies. CASE PRESENTATION: A 12-year-old girl presented with motor and sensory deficits of the left side as well as gait disturbance. Imaging revealed an intramedullary tumor extending from C2 to C7. The patient improved impressively after surgical resection. Histopathological findings were consistent with PMA. Three months later, the patient presented with rapid neurological deterioration. Histopathology after the second operation was consistent with glioblastoma. The outcome was fatal 12 months after initial diagnosis, despite adjuvant therapy. CONCLUSIONS: This is the fifth pediatric spinal cord PMA in literature. Furthermore, it is the only documented patient with rapid recurrence and progression within 3 months into a glioblastoma. The question of a sampling error affecting initial pathology is raised. Based on contemporary literature data, we discuss the further treatment options, as there are no guidelines yet. Efforts towards registries should be encouraged, as the documentation of PMA might lead to more evidence based treatment strategies.


Assuntos
Astrocitoma/patologia , Glioblastoma/patologia , Neoplasias da Medula Espinal/patologia , Vértebras Cervicais , Criança , Progressão da Doença , Evolução Fatal , Feminino , Humanos , Recidiva Local de Neoplasia/patologia
17.
Nanomaterials (Basel) ; 11(9)2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34578503

RESUMO

Metamagnetic off-stoichiometric Heusler alloys are actively being investigated because of their great potential as magnetocaloric materials. These properties are intimately related to the nanoscale homogeneity of their magnetic properties, mainly due to a strong influence of the nature of the exchange interactions between Mn atoms on the magnetism of the alloys. In this work, a spontaneous exchange bias phenomenon on a Ni-Co-Mn-Sn metamagnetic Heusler sputtered film is presented and studied in detail. More particularly, a series of DC magnetization curves measured as a function of the temperature demonstrates that the system exhibits canonical spin glass-like features. After a careful study of the field-cooling and zero-field-cooling curves measured on this system, the existence of magnetic inhomogeneities is inferred, as a consequence of the competition between ferromagnetic and antiferromagnetic exchange interactions between Mn atoms. Further AC susceptibility measurements on this system demonstrate that the underlying exchange bias phenomenon can be attributed to a magnetic clusters model based on superferromagnetic-like interactions present in the film. These findings suggest that the spontaneous exchange bias exhibited by the studied system is a consequence of the formation of this superferromagnetic-like state.

19.
Neurosurg Rev ; 34(2): 217-28, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21246391

RESUMO

This study aimed at comparing the accuracy of two commercial neuronavigation systems. Error assessment and quantification of clinical factors and surface registration, often resulting in decreased accuracy, were intended. Active (Stryker Navigation) and passive (VectorVision Sky, BrainLAB) neuronavigation systems were tested with an anthropomorphic phantom with a deformable layer, simulating skin and soft tissue. True coordinates measured by computer numerical control were compared with coordinates on image data and during navigation, to calculate software and system accuracy respectively. Comparison of image and navigation coordinates was used to evaluate navigation accuracy. Both systems achieved an overall accuracy of <1.5 mm. Stryker achieved better software accuracy, whereas BrainLAB better system and navigation accuracy. Factors with conspicuous influence (P<0.01) were imaging, instrument replacement, sterile cover drape and geometry of instruments. Precision data indicated by the systems did not reflect measured accuracy in general. Surface matching resulted in no improvement of accuracy, confirming former studies. Laser registration showed no differences compared to conventional pointers. Differences between the two systems were limited. Surface registration may improve inaccurate point-based registrations but does not in general affect overall accuracy. Accuracy feedback by the systems does not always match with true target accuracy and requires critical evaluation from the surgeon.


Assuntos
Neuronavegação/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Computadores , Apresentação de Dados , Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Imagens de Fantasmas , Reprodutibilidade dos Testes , Processamento de Sinais Assistido por Computador , Software , Cirurgia Assistida por Computador , Tomografia Computadorizada por Raios X
20.
World Neurosurg ; 111: e632-e643, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29305118

RESUMO

BACKGROUND: Following a previous systematic review of currently available endoscope holders (EHs), we aspired to detect trends, task-specific preferences, and pitfalls of EH in various cranial neuroendoscopic procedures. METHODS: A questionnaire was disseminated to members of the International Federation of Neuroendoscopy. The questionnaire evaluated indications and pitfalls of EH in different applications, in particular, differentiating between intraventricular and skull base endoscopy, as well as subcategories of these 2 main fields. Furthermore, interest or involvement in research projects on EH was investigated. RESULTS: Fifty-two surgeons responded, with a broad geographic distribution represented. Most (54%) do not routinely use EH. Others use holders mainly for intraventricular rather than skull base procedures. Most surgeons (96%) regularly work with a co-surgeon. Reported weaknesses of EH included crude movements, downward drift, loss of depth perception, lack of flexibility, iatrogenic injury, cost, and bulky construct. There is still a lack of consensus on surgical indications. Tumor resections in intraventricular and skull base regions (not small sellar tumors) seem to stand out as good, widely accepted indications. CONCLUSIONS: Although EH have a role in cranial neuroendoscopy, their use seems limited and their technical features are regarded as suboptimal by most neuroendoscopists. Weaknesses and implications were detected in all application categories (skull base and intraventricular) but may vary slightly. Potentially, separate systems with distinct features may be required for skull base versus intraventricular surgery. There is a need for further evolution of EH, which could lead to a future paradigm shift in their use.


Assuntos
Encéfalo/cirurgia , Endoscopia/instrumentação , Neuroendoscopia/instrumentação , Neurocirurgia/instrumentação , Instrumentos Cirúrgicos/estatística & dados numéricos , Neoplasias Encefálicas/cirurgia , Ventrículos Cerebrais/cirurgia , Endoscopia/tendências , Humanos , Neuroendoscópios , Neuroendoscopia/tendências , Neurocirurgiões , Neurocirurgia/tendências , Equipe de Assistência ao Paciente , Base do Crânio/cirurgia , Instrumentos Cirúrgicos/efeitos adversos , Instrumentos Cirúrgicos/tendências , Inquéritos e Questionários
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