Detalhe da pesquisa
1.
Exploring the structural activity relationship of the Osimertinib: A covalent inhibitor of double mutant EGFRL858R/T790M tyrosine kinase for the treatment of Non-Small Cell Lung Cancer (NSCLC).
Bioorg Med Chem
; 109: 117796, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38879996
2.
Synthesis, biological evaluation, and In silico molecular docking of N-(4-(4-substitutedphenyl)-6-(substituted aryl) pyrimidin-2-yl)-2-(2-isonicotinoyl hydrazinyl) acetamide.
J Biochem Mol Toxicol
; 38(1): e23634, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38229312
3.
Benzimidazole and piperidine containing novel 1,2,3-triazole hybrids as anti-infective agents: Design, synthesis, in silico and in vitro antimicrobial efficacy.
J Biochem Mol Toxicol
; 38(1): e23526, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37668402
4.
Anti-malarial and Multi-bioactive Co (II), Cu (II) and Ni (II) Salen Complexes: Synthesis, Characterization and Computational Studies.
Chem Biodivers
; : e202400715, 2024 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38825566
5.
Design, synthesis, biological evaluation, and in silico studies of quinoxaline derivatives as potent p38α MAPK inhibitors.
Arch Pharm (Weinheim)
; 357(1): e2300301, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37847883
6.
Design and synthesis of some novel hybrid molecules based on 4-thiazolidinone bearing pyridine-pyrazole scaffolds: molecular docking and molecular dynamics simulations of its major constituent onto DNA gyrase inhibition.
Mol Divers
; 2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36750538
7.
Microwave produced 8-methyl-1,2,4,8-tetraazaspiro[4.5]dec-2-en-3-amine derivatives: their in vitro and in silico analysis.
Mol Divers
; 2023 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37280405
8.
Chrysin based pyrimidine-piperazine hybrids: design, synthesis, in vitro antimicrobial and in silico E. coli topoisomerase II DNA gyrase efficacy.
Mol Divers
; 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37318711
9.
Design and synthesis of pyrrolo[2,3-d]pyrimidine linked hybrids as α-amylase inhibitors: molecular docking, MD simulation, ADMET and antidiabetic screening.
Mol Divers
; 2023 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37344700
10.
Mycobacterial FtsZ and inhibitors: a promising target for the anti-tubercular drug development.
Mol Divers
; 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010605
11.
Synthesis, Biological Evaluation, and Molecular Modeling Studies of New 1,3,4-Thiadiazole Derivatives as Potent Antimicrobial Agents.
Chem Biodivers
; 20(3): e202201146, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764924
12.
Illicium verum L. (Star Anise) Essential Oil: GC/MS Profile, Molecular Docking Study, In Silico ADME Profiling, Quorum Sensing, and Biofilm-Inhibiting Effect on Foodborne Bacteria.
Molecules
; 28(23)2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38067422
13.
Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents.
Bioorg Chem
; 122: 105709, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35255344
14.
Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches.
Molecules
; 27(21)2022 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364077
15.
Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action.
Molecules
; 27(24)2022 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36557897
16.
Synthesis, molecular docking, DFT study, and in vitro antimicrobial activity of some 4-(biphenyl-4-yl)-1,4-dihydropyridine and 4-(biphenyl-4-yl)pyridine derivatives.
J Biochem Mol Toxicol
; 35(11): e22903, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459052
17.
Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC).
Bioorg Chem
; 115: 105234, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34399322
18.
Novel thiomorpholine tethered isatin hydrazones as potential inhibitors of resistant Mycobacterium tuberculosis.
Bioorg Chem
; 115: 105133, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34329993
19.
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations.
Int J Mol Sci
; 22(19)2021 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34639036
20.
Is there seasonal variation in gallstone related admissions in England?
HPB (Oxford)
; 23(11): 1732-1743, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33975800