Detalhe da pesquisa
1.
Differential recognition of HIV-stimulated IL-1ß and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.
PLoS Pathog
; 17(4): e1009417, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33861800
2.
Peracid Oxidation of Unactivated sp3 C-H Bonds: An Important Solvent Effect.
Chemistry
; 29(31): e202204007, 2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36888902
3.
One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
Chemistry
; 27(71): 17880-17888, 2021 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34328642
4.
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Angew Chem Int Ed Engl
; 59(47): 21096-21105, 2020 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32745361
5.
Efficient methods for enol phosphate synthesis using carbon-centred magnesium bases.
Org Biomol Chem
; 13(40): 10131-5, 2015 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411833
6.
Single-step microwave-mediated synthesis of oxazoles and thiazoles from 3-oxetanone: a synthetic and computational study.
Chemistry
; 19(29): 9655-62, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23765429
7.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
J Med Chem
; 65(22): 15174-15207, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36378954
8.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903390
9.
Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ.
ACS Chem Biol
; 16(9): 1644-1653, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34397208
10.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34510892
11.
A Turing Test for Molecular Generators.
J Med Chem
; 63(20): 11964-11971, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955254
12.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904959
13.
Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.
Org Lett
; 19(23): 6368-6371, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29135268
14.
Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor.
ACS Med Chem Lett
; 8(1): 43-48, 2017 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28105273
15.
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J Med Chem
; 59(23): 10738-10749, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933945
16.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167608
17.
A practical drug discovery project at the undergraduate level.
Drug Discov Today
; 18(23-24): 1158-72, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24051399
18.
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
J Med Chem
; 52(20): 6257-69, 2009 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19772287
19.
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Bioorg Med Chem Lett
; 17(15): 4363-8, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17600705
20.
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.
Bioorg Med Chem Lett
; 16(14): 3784-8, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697194