Detalhe da pesquisa
1.
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.
PLoS Genet
; 9(5): e1003546, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23737759
2.
Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27.
Cell Cycle
; 21(1): 12-32, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34913830
3.
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition.
Mol Oncol
; 2022 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36453028
4.
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".
Mol Cell Biol
; 26(13): 5070-85, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16782892
5.
Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture.
Mol Endocrinol
; 20(12): 3279-92, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16916940
6.
CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.
EMBO Mol Med
; 9(8): 1052-1066, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28566333
7.
The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.
Cell Cycle
; 13(18): 2879-88, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25486476
8.
Commentary: Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.
Front Endocrinol (Lausanne)
; 8: 214, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28890710
9.
cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.
Mol Endocrinol
; 24(7): 1453-68, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484410
10.
Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.
Cell Cycle
; 9(4): 689-99, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20107323
11.
Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.
Cancer Res
; 69(11): 4577-81, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19458076
12.
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.
Mol Cell Biol
; 29(15): 4188-200, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19487459
13.
Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.
Mol Biol Cell
; 19(11): 4814-25, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18799615
14.
Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: differential involvement in the distinct mitogenic modes of thyroid epithelial cells.
Cell Cycle
; 5(1): 61-70, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16294008
15.
16.
Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.
J Biol Chem
; 278(52): 52052-60, 2003 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14551212
17.
Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.
J Biol Chem
; 278(29): 26533-40, 2003 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12730225
18.
The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis.
Exp Cell Res
; 291(1): 135-49, 2003 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14597415